A5018935515- Rheumatoid Arthritis Research and Therapies
- Systemic Lupus Erythematosus Research
- Autoimmune and Inflammatory Disorders Research
- Systemic Sclerosis and Related Diseases
- Monoclonal and Polyclonal Antibodies Research
- Spondyloarthritis Studies and Treatments
- Inflammasome and immune disorders
- Chronic Disease Management Strategies
- Musculoskeletal Disorders and Rehabilitation
- Lymphoma Diagnosis and Treatment
- HER2/EGFR in Cancer Research
- Cardiovascular Health and Disease Prevention
- Hepatitis C virus research
- Pharmaceutical Practices and Patient Outcomes
- Pharmaceutical studies and practices
- Orthopedic Infections and Treatments
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Cardiac Fibrosis and Remodeling
- Nursing Roles and Practices
- Viral Infections and Immunology Research
- Hematological disorders and diagnostics
Vilnius University
2004-2023
State Research Institute Centre for Innovative Medicine
2001-2023
Vilnius University Hospital Santariskiu Klinikos
2011
Abstract Objective Regular physical activity is associated with decreased morbidity and mortality. Traditionally, patients rheumatoid arthritis (RA) have been advised to limit exercise. We studied the prevalence of associations demographic disease‐related variables in RA from 21 countries. Methods The Questionnaires Standard Monitoring Patients Rheumatoid Arthritis (QUEST‐RA) a cross‐sectional study that includes self‐report questionnaire clinical assessment nonselected consecutive...
Abstract Introduction Work disability is a major consequence of rheumatoid arthritis (RA), associated not only with traditional disease activity variables, but also more significantly demographic, functional, occupational, and societal variables. Recent reports suggest that the use biologic agents offers potential for reduced work rates, conclusions are based on surrogate measures derived from studies primarily Western countries. Methods The Quantitative Standard Monitoring Patients RA...
To analyse associations between the clinical status of patients with rheumatoid arthritis (RA) and gross domestic product (GDP) their resident country.The Quantitative Standard Monitoring Patients Rheumatoid Arthritis (QUEST-RA) cohort includes questionnaire data from 6004 who were seen in usual care at 70 rheumatology clinics 25 countries as April 2008, including 18 European countries. Demographic variables, characteristics, RA disease activity measures, score 28 joints (DAS28),...
Activated rheumatoid arthritis (RA) synovial fibroblasts (SFs) are among the most important cells promoting RA pathogenesis. They considered active contributors to initiation, progression, and perpetuation of disease; therefore, early detection RASF activation could advance contemporary diagnosis adequate treatment undifferentiated inflammatory (EA). In this study, we investigated expression nucleotide-binding, oligomerization domain (NOD)-like receptor family, pyrin containing (NLRP)1,...
To evaluate labor force characteristics among patients with rheumatoid arthritis (RA) in Lithuania. assess if Lithuania's transition from a state-planned to free-market economy after 1990 changed the employment perspectives of RA.RA patients, age 16-65 years (n = 238), were randomly selected RA register Vilnius. They completed questions about sociodemographics, working status, and disease characteristics, they underwent clinical examination, modified Health Assessment Questionnaire Short...
Background and Objectives: Early undifferentiated arthritis (UA) is a group of inflammatory joint diseases that are not classified under any specific rheumatic or connective tissue disorder might evolve into chronic may be self-limiting condition. recognition treatment crucial for the future course disease. Vascular endothelial growth factor (VEGF) an angiogenic regulator induces new capillary blood vessels, which important in invasion destruction during progression arthritis. The aim this...
Increased mortality and shorter survival among rheumatoid arthritis (RA) patients are recognized but not fully explained. This cohort study aimed to identify predictors of RA at a tertiary clinical setting.Patients with were recruited during 1998-2003 followed up until April 1, 2012, or death whichever happened first. Baseline variables included sociodemographic disease characteristics, comorbidities. Cox regression hazard risk (HR) computed estimate risks for mortality.One hundred...
To estimate the burden of rheumatoid arthritis (RA) in Vilnius, Lithuania, former socialist country Eastern Europe, terms patients' need for help from other persons and to explore factors which influence physical help.Some 537 patients with RA, registered answered questions about socio-demographics, disease characteristics, categories required help, use major appliances adaptations, underwent a clinical examination filled modified health assessment questionnaire (MHAQ) impact measurement...
Background. To provide data on the use of anti-cyclic citrullinated peptide antibody (anti-CCP) and other routinely used clinical parameters to assess impact anti-CCP status therapeutic decisions, an observational study was conducted in patients with rheumatoid arthritis (RA). Methods. Sixty-seven adult a recent diagnosis RA were recruited from four rheumatology centres Lithuania prospectively observed for 12 months. Data collection based review medical records routine examination patients....
<h3>Background</h3> In Bone and Joint Decade comparative studies between countries could contribute to better understanding of disease burden rheumatic diseases. <h3>Objectives</h3> To compare health status measures in RA patient cohorts from Vilnius, Lithuania Oslo, Norway. <h3>Methods</h3> For 201 patients Vilnius register, matched cases according age (mean 55.9 (SD1.0)) gender (167 female) were identified Oslo register. Study variables included sociodemographic characteristics, (MHAQ,...
<h3>Background</h3> Joint replacement surgery represents a remarkable mile stone in the care of patients with rheumatoid arthritis (RA), aimed at improving patients9 functional capacity and reducing pain. Prior to current therapeutic strategies, surgical joint intervention was frequent event. Currently, orthopedic is considered as surrogate marker failed medical treatment destruction. <h3>Objectives</h3> To compare disease burden RA without major operation (MJO) QUEST-RA study....
Background and Objectives: About 40% of early undifferentiated arthritis (UA) progresses to rheumatoid (RA) or other chronic arthritis. Novel diagnostic tools predicting the risk for this progression are needed identify patients who would benefit from aggressive treatment. Evidence on role single-nucleotide polymorphisms (SNPs) in development RA has emerged. The aim our study was investigate association between rs2476601, rs833070, rs6920220 SNPs UA RA. Materials Methods: Ninety-two were...
<h3>Background:</h3> It has been shown that a variety of environmental and genetic factors, as well deficiency vitamin D plays key role in outcomes arthritis. Many studies have the central feature synovitis rheumatoid arthritis (RA) is activated synovium fibroblasts (SF) play expression secretion distinct patterns inflammatory factors. Recent demonstrated nucleotide-binding oligomerisation domain-like receptor (NLR) containing PYRIN domain 1 (NLRP1) NLRP3 inflammasomes Toll-like receptors...
<h3>Background</h3> It is commonly recognised that outcome measures in rheumatoid arthritis depend on the duration of disease and especially disability index reveals link while others demonstrate minor changes course disease. <h3>Objectives</h3> To test latter hypotheses we performed study which aimed to measure long-term outcomes 225 patients – Vilnius city inhabitants. <h3>Methods</h3> The were asked fill self-administered questioners as follows: Stanford HAQ (0–3,3 worth health),...