A5087535771- Rheumatoid Arthritis Research and Therapies
- Monoclonal and Polyclonal Antibodies Research
- Autoimmune and Inflammatory Disorders Research
- Systemic Lupus Erythematosus Research
- Spondyloarthritis Studies and Treatments
- Chronic Lymphocytic Leukemia Research
- Toxin Mechanisms and Immunotoxins
- Viral Infections and Immunology Research
- Systemic Sclerosis and Related Diseases
- Sarcoidosis and Beryllium Toxicity Research
- Immunodeficiency and Autoimmune Disorders
- Cytokine Signaling Pathways and Interactions
- HER2/EGFR in Cancer Research
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Medical and Biological Sciences
- Healthcare Systems and Public Health
- Biosimilars and Bioanalytical Methods
- Bone and Joint Diseases
- Psoriasis: Treatment and Pathogenesis
- Osteoarthritis Treatment and Mechanisms
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Inflammasome and immune disorders
- Myofascial pain diagnosis and treatment
- COVID-19 Clinical Research Studies
- Musculoskeletal Disorders and Rehabilitation
Regional Clinical Research
2018-2024
Moscow Regional Scientific Research Clinical Institute. MF Vladimirsky
2018-2023
Moscow Regional Research Institute of Obstetrics and Gynecology
2018-2019
VA Nasonova Scientific Research Institute of Rheumatology
2013-2017
Arthritis Australia
2013-2015
Russian Academy of Sciences
2009-2014
Institute of Rheumatology
2010-2013
Center for Rheumatology
2013
Gender as a predictor of outcomes rheumatoid arthritis (RA) has evoked considerable interest over the decades. Historically, there is no consensus whether RA worse in females or males. Recent reports suggest that are less likely than males to achieve remission. Therefore, we aimed study possible associations gender and disease activity, characteristics, treatments large multinational cross-sectional cohort patients with called Quantitative Standard Monitoring Patients (QUEST-RA).The includes...
To analyse associations between the clinical status of patients with rheumatoid arthritis (RA) and gross domestic product (GDP) their resident country.The Quantitative Standard Monitoring Patients Rheumatoid Arthritis (QUEST-RA) cohort includes questionnaire data from 6004 who were seen in usual care at 70 rheumatology clinics 25 countries as April 2008, including 18 European countries. Demographic variables, characteristics, RA disease activity measures, score 28 joints (DAS28),...
Glucocorticoids (GCs) are often used as early arthritis treatment and it has been suggested that they induce remission or at least delay the development of rheumatoid (RA) need to start disease-modifying antirheumatic drugs (DMARDs).To test effect GCs on patients with very (symptom duration <16 weeks) in a randomised controlled trial.Patients received single intramuscular injection 120 mg methylprednisolone placebo (PL) were followed up for 52 weeks. Primary end point was drug-free clinical...
The Effects of Rituximab on Lipids
Russian Society of Cardiology (RSC) With the participation: Eurasian Association Therapists (EUAT), Specialists in Heart Failure (OSSN), Scientific Medical (RNMOT), Pathologists, Radiologists and (RSR) Endorsed by: Research Practical Council Ministry Health Federation
Physician awareness and perceptions towards biosimilars are important factors in their adoption to clinical practice. Our objectives were assess levels of knowledge attitudes key policies on use among Russian physicians, define the level interest new information biosimilars, determine what evidence drives treatment decisions Russia. Physicians with biologics across different specialties regions Russia completed an online survey. A Likert other rating scales used collect opinions, which...
Background: The COVID-19 pandemic is seriously affecting the society and economy of many countries, including Russian Federation. Identifying major risk factors for an unfavorable outcome could help save lives reduce disease burden. Until now, no results studies on this issue based clinical material have been published. Aim: To evaluate effects comorbidities (discharge or hospital death rates) in patients hospitalized with a diagnosis COVID-19. Materials methods : We analyzed database 13,585...
Abstract Objectives RA patients who fail to respond MTX can receive biologic dMARDs (bDMARDs). The Torque Teno Virus (TTV) is a potential novel candidate for monitoring of immunosuppression. We explore TTV in these and its association with clinical response bDMARDs. Methods BioBio Study multicentre randomized open-label trial, including insufficient MTX. Patients were either TNFi (infliximab, INF), anti-IL-6 (tocilizumab, TCZ), CTLA4-Ig (abatacept, ABA) or anti-CD20 (rituximab, RTX) addition...
We evaluated changes in gene expression of mTOR , p21 caspase-3 ULK1 TNF α matrix metalloproteinase ( MMP)-9 and cathepsin K the whole blood rheumatoid arthritic (RA) patients treated with methotrexate (MTX) relation to their factor status, clinical, immunological, radiological parameters, therapeutic response after a 24-month follow-up. The study group consisted 35 control subjects 33 RA without previous history MTX treatment. Gene was measured using real-time RT-PCR. Decreased disease...
Authors report new recommendations of All-Russian Public Organization «Association Rheumatologists Russia» (ARR) on treatment rheumatoid arthritis (RA), which adapts contemporary concept accepted in the respective field pharmacotherapy known as «Treat to Target». According it, main objective RA is a remission (or low disease activity). To achieve modifying anti-rheumatic drugs (DMARD) should be administered all patients early possible, with efficacy monitoring and therapy correction...
The paper presents the materials of Russian Arthritis Registry (OREL) that includes 3276 patients from 11 Russian Federation's largest research-and-practical centers situated in Moscow, Saint Petersburg, Novosibirsk, Kazan, Tula, Yaroslavl, Tyumen. It discusses main goals setting up registries, compares results an analysis data available OREL and registries European countries USA. findings suggest that there is non-uniform information on clinical, laboratory, instrumental parameters national...
Rheumatic diseases of juxta-articular soft tissues (RDJAST) (tendinitis, tenosynovitis, bursitis, etc.) are one the most common causes disability and reasons for seeking medical advice. To manage patients with RDJAST is an important part practising rheumatologists' work. But unfortunately, issues diagnosis therapy this pathology have been relatively rarely discussed on pages Russian journals at scientific congresses conferences rheumatologists in recent years. This review to refresh...
Reduction in tumor necrosis factor (αTNF) and interleukin-6 (IL-6) activities is a widely utilized strategy for the treatment of rheumatoid arthritis (RA) with high success rate. Despite both schemes targeting deprivation inflammatory reactions caused by excessive activity cytokines, their mechanisms action final output are still unequal. This was comparative longitudinal study that lasted 24 weeks aimed to find answer why two therapy can pass out proportion attitude efficiency. What...
To investigate the potential of baseline gene expression in whole blood disease-modifying anti-rheumatic drug-naïve rheumatoid arthritis (RA) patients for predicting response to methotrexate (MTX) treatment. Twenty-six control subjects and 40 RA were examined. Clinical, immunological radiographic parameters assessed before after 24 months follow-up. The expressions measured using real-time reverse transcription polymerase chain reaction. protein concentrations peripheral mononuclear cells...
Objective: to investigate the immunogenicity, safety, and clinical efficacy of 23-valent polysaccharide pneumococcal vaccine in patients with rheumatoid arthritis (RA) during a two-year follow-up study. Subjects methods. The prospective open-label comparative study enrolled 110 people, them there were 81 (73.6%) women 29 (26.4%) men at age 23 76 years, including 79 RA, as well 31 subjects without systemic inflammatory rheumatic diseases (RD) (a control group). group RA exhibited predominance...
The current treatment strategy for rheumatoid arthritis (RA) is based on the principles of early aggressive therapy and tight control, which are summarized in «Treat-to-Target» recommendations. draft RA guidelines by Association Rheumatologists Russia (ARR) reflect these expanded form. Twenty-four ARR recommendations contain detailed description treatments RA, relies evidence-based medicine. Some practical issues management patients with require special attention. comparison a number...