A5101812901- Psoriasis: Treatment and Pathogenesis
- Immune Cell Function and Interaction
- T-cell and B-cell Immunology
- Immunotherapy and Immune Responses
- Soybean genetics and cultivation
- Monoclonal and Polyclonal Antibodies Research
- Traffic and Road Safety
- COVID-19 Clinical Research Studies
- Food Quality and Safety Studies
- Dermatology and Skin Diseases
- Health Systems, Economic Evaluations, Quality of Life
- Injury Epidemiology and Prevention
- Endometriosis Research and Treatment
- Reproductive System and Pregnancy
- Agriculture and Farm Safety
- Menopause: Health Impacts and Treatments
- Chemical Synthesis and Analysis
- Environmental and Agricultural Sciences
- Reproductive biology and impacts on aquatic species
- Comparative Animal Anatomy Studies
- Nutrition, Genetics, and Disease
- Liver Disease Diagnosis and Treatment
- Tryptophan and brain disorders
- Thermal Regulation in Medicine
- Advanced Biosensing Techniques and Applications
Xiangya Hospital Central South University
2020-2025
Central South University
2020-2025
Central China Normal University
2025
Zhujiang Hospital
2024
Hunan Cancer Hospital
2022-2024
Southern Medical University
2010-2024
National Clinical Research Center for Digestive Diseases
2020-2023
Institute of Basic Medical Sciences of the Chinese Academy of Medical Sciences
2020
Westlake University
2020
Kunming Third People's Hospital
2019
ABSTRACT Accurate container throughput forecasting is critical for enhancing port efficiency and ensuring global trade stability, particularly in the face of economic uncertainties, geopolitical tensions, supply chain disruptions. Existing methods often struggle to model nonlinear, nonstationary, noise‐laden characteristics data, creating a clear gap ability provide reliable predictions. To address this, we propose novel hybrid model, VMD‐ISE‐TCNT, designed tackle these challenges. The...
Psoriasis is an inflammatory disease linked to gut microbiome dysbiosis. However, the mechanisms underlying changes caused by dietary habits in psoriasis remain unclear. We performed a case-control study including 64 patients and age-, sex-, body mass index (BMI)-matched controls. Stool samples were collected for metagenomics sequencing. The differential abundance analysis was identify differentially abundant taxa between control groups. intake frequency information of each included subject...
Although sarcopenia has been linked to a range of cardiometabolic diseases (CMDs, including coronary heart disease [CHD], stroke, and diabetes here), its role in the temporal progression from healthy single CMD, subsequently multimorbidity (CMM, coexistence ≥ 2 CMDs an individual), further death remains unclear. In this study, we aimed examine associations with risk CMDs, CMM, mortality along CMD trajectory. We used data UK Biobank 413,326 participants free at baseline. Multi-state models...
ABSTRACT The molecular pathology of multi-organ injuries in COVID-19 patients remains unclear, preventing effective therapeutics development. Here, we report an in-depth proteomic landscape patient autopsy samples. By integrative analysis proteomes seven organs, namely lung, spleen, liver, heart, kidney, thyroid and testis, characterized 11,394 proteins, which 5336 were perturbed compared to controls. Our data showed that CTSL, rather than ACE2, was significantly upregulated the lung from...
Human umbilical cord mesenchymal stem cells (UC-MSCs)-derived hepatocyte-like (HLCs) have shown great promise in the treatment of liver diseases. However, most current induction protocols yield with limited function as compared primary hepatocytes. Schisandrin B (Sch B) is one main components
Twelve novel human leukocyte antigen class II alleles are described; eight DRB1 and four DQB1 alleles. Nine of the variants single nucleotide substitutions from their most homologous allele, which six result in amino acid changes (DRB1*0459, *1156 *1522; DQB1*0205, *0320 *0321) three silent (DRB1*030105 *040304, DQB1*030104). The remaining (DRB1*0906, *1464 *1468) differ similar by two to alter one acids.
Objective: To explore the possible mechanism of improving imiquimod (IMQ)-induced psoriasis-like inflammation by using polyethylene glycol (PEG) ointment. Methods: We evaluated appearance psoriasis lesions Psoriasis Area and Severity Index (PASI), observed epidermal proliferation histopathological staining immunohistochemical staining, explored key molecules signaling pathways treated with PEG ointment RNA sequencing. Finally, we verified expression inflammatory cells factors flow cytometry,...
Abstract Twenty‐three novel human leukocyte antigen‐B alleles are described: B*070204, *0738, *0742, *0821, *130202, *1312, *1575, *1598, *1599, *270507, *2728, *350104, *3558, *3811, *3931, *3932, *4045, *4107, *420501, *4812, *510106, *5520, and *5616. Thirteen of the variants single‐nucleotide substitutions from their most homologous allele, eight resulting in amino acid changes (B*0742, *5616) five with silent (B*070204, *510106). Three (B*0738, *5520) differ by nucleotide changes,...
Abstract Twenty‐eight novel human leukocyte antigen‐B alleles are described: one B*07 (*0745), two B*08 (*0826 and *0831), B*27 (*2731), four B*35 (*350106, *350402, *3566, *3568), B*37 (*370102 *3711), B*38 (*380102 *3813), B*39 (*3935 *3939), B*41 (*4108), B*42 (*4209), B*44 (*4444 *4448), B*48 (*480302 *4815), B*51 (*5140), B*55 (*5523), B*56 (*5617), B*57 (*570103 *5710), three B*15 (*9505, *9510, *9519). Sixteen of the variants single‐nucleotide substitutions from their most homologous...
Background Previous studies on the associations between socioeconomic status (SES) and cutaneous malignant melanoma (CMM) failed to distinguish effects of different SES factors under an individual-data-based prospective study design. Methods Based UK Biobank (UKB) China Kadoorie (CKB), we estimated four transitions from baseline CMM in situ, subsequently invasive further mortality by applying multistate models. We explored which extent incidence could be explained potential mediators...
Abstract One hundred and four novel human leukocyte antigen (HLA) alleles are described from volunteer donors of the National Marrow Donor Program: 37 HLA‐A alleles, HLA‐B 30 HLA‐DRB1 alleles. Seventeen (∼16%) were found in multiple individuals likely relatively common population. Seventy‐two (∼69%) 104 single nucleotide substitution variants when compared with their most homologous allele. Nine these silent substitutions three create null The remaining differ similar allele by two to seven...
HLA class I assignments were obtained at single genotype, G-level resolution from 98 855 volunteers for an unrelated donor registry in the United States. In spite of diverse ancestry volunteers, over 99% each locus are common. Within this population, 52 novel alleles differing exons 2 and 3 identified characterized. Previously reported with incomplete sequences IPD-IMGT/HLA database (n = 519) selected full gene sequencing and, sampling, another 27 described.
This study investigated host responses to long COVID by following up with 89 of the original 144 cohorts for 1-year (
Abstract The frequencies of DRB1*12 alleles were determined in four US population groups by DNA sequencing. Only DRB1*120101 (or DRB1*1206 or *1210) and DRB1*120201 identified, the latter primarily Asian American population. Additional testing a subset samples to detect presence found all be DRB1*1210). Retesting six previously typed as only
Abstract Willingness‐to‐pay (WTP) and time‐trade‐off (TTO) are widely used as measures of disease burden. However, the sensitivity metrics has not been compared in psoriasis. This article aims to report WTP TTO Chinese psoriasis patients, compare cure (USD), control (%), regarding measuring burden Patients were recruited from a community‐based cohort, tertiary hospital, an online forum. was elicited for two scenarios: controlling curing disease. by asking about percentage monthly income that...
The product of Physician Global Assessment (PGA) and Body Surface Area (BSA) (PGA × BSA) has been proposed as a simple sensitive instrument for measuring psoriasis severity. To assess the measure, PGA BSA, with respect to criterion validity, reproducibility, responsiveness, interpretability among Chinese patients psoriasis. Assessments severity were performed by two dermatologists independently baseline survey one dermatologist during follow-up. Criterion validity reproducibility assessed...
Pseudomonas aeruginosa requires its type III secretion system (T3SS) to facilitate acute infections. T3SS-related gene expression is controlled by the AraC-type transcriptional activator ExsA. A signaling cascade involving ExsA and three additional proteins -ExsC, ExsD, ExsE directly ties up-regulation of transcription activation apparatus. In order characterize molecular interactions underlying process crystal structures unique T3SS chaperone ExsC in complex with cognate effector ExsE,...
Whether metformin and its adenosine 5'monophosphate-activated protein kinase (AMPK) activation protect from psoriasis risk is unconcluded. We investigated the effect of AMPK, a pharmacological target metformin, on comorbidities mortality among participants in UK Biobank (UKB).