A5015860691- Atrial Fibrillation Management and Outcomes
- Acute Myocardial Infarction Research
- Cardiac Arrhythmias and Treatments
- Viral Infections and Immunology Research
- COVID-19 Clinical Research Studies
- Cardiac Imaging and Diagnostics
- Antiplatelet Therapy and Cardiovascular Diseases
- Cardiac electrophysiology and arrhythmias
- Cardiac Structural Anomalies and Repair
- Venous Thromboembolism Diagnosis and Management
- Long-Term Effects of COVID-19
- Cardiac, Anesthesia and Surgical Outcomes
- Cardiovascular Effects of Exercise
- Cardiomyopathy and Myosin Studies
- Cardiac Arrest and Resuscitation
- Cardiac Valve Diseases and Treatments
- Emergency and Acute Care Studies
- Muscle Physiology and Disorders
- Fungal Infections and Studies
- Diagnosis and Treatment of Venous Diseases
- Cancer Immunotherapy and Biomarkers
- Coronary Interventions and Diagnostics
- Ultrasound in Clinical Applications
- RNA regulation and disease
- Cardiac tumors and thrombi
University Hospital Heidelberg
2017-2025
Heidelberg University
2017-2025
German Centre for Cardiovascular Research
2019-2025
Background: Immune checkpoint inhibitor (ICI) therapy is often accompanied by immune-related pathology, with an increasing occurrence of high-risk ICI-related myocarditis. Understanding the mechanisms involved in this side effect could enable development management strategies. In mouse models, immune checkpoints, such as PD-1 (programmed cell death protein 1), control threshold self-antigen responses directed against cardiac TnI (troponin I). We aimed to identify how immunoproteasome, main...
For the majority of patients with atrial fibrillation (AF), disease management has improved in recent years. However, there are still populations underrepresented or excluded current registries and randomized controlled trials. HERA-FIB (Heidelberg Registry Atrial Fibrillation) was planned to assess real-world evidence for prevalence, demographic characteristics diagnosis AF presenting consecutively a chest pain unit.
Abstract Background Major bleedings following coronary artery bypass grafting (CABG) have significant implications on outcomes in acute syndrome (ACS) patients. Owing fears of fatal case urgent CABG, current guidelines recommend a cessation P2Y 12 receptor antagonists (P2Y -RA) before cardiac surgery and opt against routine pre-treatment with -RA angiography (CA). However, sparse information exists outside randomized trials the frequency CABG consequences inappropriately long treatment...
(1) Background: Prompt acute coronary syndrome (ACS) recognition remains challenging. This study evaluated the diagnostic and prognostic performance of novel biomarkers for non-ST-elevation myocardial infarction (NSTEMI). (2) Methods: Patients with suspected ACS presenting to Heidelberg University Hospital’s Emergency Department between August 2014 February 2023 were analyzed. The biomarker panel included high-sensitivity cardiac troponin T (hs-cTnT), myosin-binding protein C (cMyBP-C),...
Background This study compared the diagnostic and prognostic performance of various non–ST‐segment myocardial infarction (NSTEMI) rule‐out protocols, incorporating cardiac myosin‐binding protein C (cMyBP‐C), high‐sensitivity troponin T (hs‐cTnT), Copeptin, both individually as part dual‐marker strategies (DMSs) against European Society Cardiology 0/1‐hour 0/3‐hour algorithms. Methods We enrolled 1765 patients presenting to emergency department with suspected NSTEMI. evaluated biomarker...
Concentrations of high-sensitivity cardiac troponin T (hs-cTnT) are frequently elevated in stable patients with confirmed muscle dystrophies. However, sparse information is available on the interpretation serial concentration changes.
As the population ages, atrial fibrillation (AF) prevalence increases, but data on optimal oral anticoagulation (OAC) in patients ≥80 years remain limited. This study tested whether direct OACs offer comparable benefits to vitamin K antagonists with AF presenting emergency department. single-center retrospective all-comer used from Heidelberg Registry of Atrial Fibrillation, including department University Hospital June 2009 until March 2020. Data were analyzed by age for outcomes and risk...
Evidence suggests a benefit of rhythm control approach in patients with recent diagnosis atrial fibrillation (AF). This study sought to evaluate clinical characteristics, treatment strategies and outcomes first diagnosed AF (FDAF) undergoing non-invasive strategy an emergency department (ED). analysis uses data from the Heidelberg Registry Atrial Fibrillation (HERA-FIB). HERA-FIB is retrospective single-centre observational which consecutively included presenting ED University Hospital...
High-sensitivity cardiac troponin tests have enhanced early myocardial infarction diagnosis, yet many patients still land in the observe zone (OZ). Guidelines suggest a 3-hour measurement for those European Society of Cardiology (ESC) 0/1 hour-algorithm's OZ, but evidence on extended testing times and their impact diagnostic accuracy outcomes remains sparse. Patients with suspected acute coronary syndrome were consecutively enrolled single-centre observational study. The triage protocol...
Abstract Background While high-sensitivity cardiac troponin testing has improved the early diagnosis of myocardial infarction, a substantial number patients remain in observe zone (OZ). Recent guidelines recommend rapid protocols and 3h measurement triaged to OZ ESC 0/1h-algorithm, but evidence on extended times their impact diagnostic accuracy outcomes remains sparse. Methods Patients with suspected acute coronary syndrome were enrolled single-centre observational study. The 0/1-hour...
Abstract Background Major bleedings following coronary artery bypass grafting (CABG) have significant implications on outcomes in acute syndrome (ACS) patients. Owing fears of fatal case urgent CABG, current guidelines recommend a cessation P2Y12 receptor antagonists (P2Y12-RA) before cardiac surgery and opt against routine pre-treatment with P2Y12-RA angiography (CA). However, sparse information exists outside randomized trials the frequency CABG consequences inappropriately long treatment...
Abstract Background A significant number of patients with atrial fibrillation (AF) on direct oral anticoagulants (DOACs) receives off-label or inappropriate doses. This study examines the prevalence, dosages, and clinical outcomes in AF-patients DOAC therapy admitted to an emergency department (ED). Methods retrospective single-center observational utilized data from Heidelberg Registry Atrial Fibrillation (HERA-FIB), consecutively including AF presenting ED University Hospital our city June...
Abstract Background Current guidelines recommend additional diagnostic work-up for patients with suspected non-ST-elevation acute coronary syndrome (NSTE-ACS) triaged in the observe zone using accelerated protocols. This study assessed effectiveness of combining Global Registry Acute Coronary Events (GRACE) 1.0 score non-cardiospecific biomarkers risk stratification zone. Methods A total 6,789 NSTE-ACS were enrolled over 24 months, 961 (21.8%) assigned to classification and regression tree...
Abstract Background This study compared the diagnostic and prognostic performance of various non-ST myocardial infarction (NSTEMI) rule-out-protocols, incorporating cardiac myosin-binding protein C (cMyBP-C), high-sensitivity troponin T (hs-cTnT), Copeptin, both individually as part dual-marker strategies (DMS) against European Society Cardiology (ESC) 0/1h- 0/3h-algorithms. Methods We enrolled 1,765 patients presenting to emergency department (ED) with suspected NSTEMI. evaluated biomarker...
Abstract Treatment of myocarditis is often limited to symptomatic treatment due unknown pathomechanisms. In order identify new therapeutic approaches, the contribution locked nucleic acid antisense oligonucleotides (LNA ASOs) in autoimmune was investigated. Hence, A/J mice were immunized with cardiac troponin I (TnI) induce experimental (EAM) and treated LNA ASOs. The results showed an unexpected anti‐inflammatory effect for one administered ASO MB_1114 by reducing inflammation fibrosis....
Background Management of patients with non-ST-segment-elevation acute coronary syndrome (NSTE-ACS) is based on 2020 European Society Cardiology guidelines, which recommend the preferential use prasugrel over ticagrelor. Because selection respective P2Y12 inhibitor has to consider label restrictions, we sought evaluate proportion qualifying for either ticagrelor or and reasons noneligibility in an unselected cohort syndrome. Methods Results In this retrospective observational study,...
Application of the 4th version Universal Definition Myocardial Infarction (UDMI) to characterize rates and prognostic relevance myocardial injury in COVID-19 disease.This retrospective, single-centre observational study enrolled 104 patients hospitalized with SARS-CoV-2 infection. Kaplan-Meier analysis multivariate Cox regression were used identify influence acute or chronic on a composite primary (mortality, incident respiratory distress syndrome, mechanical ventilation) secondary endpoint...
Background An established objective and standardized reporting of clinical severity disease progression in COVID-19 is still not established. We validated compared the usefulness two classification systems reported earlier–a grading proposed by Siddiqi a system from National Australian guideline. Both had been externally were now tested for their ability to predict complications. Methods In this retrospective, single-centre observational study, patients hospitalized with confirmed across all...
Abstract An accurate diagnosis of venous thromboembolism (VTE) is crucial, given the potential for high mortality in undetected cases. Strategic D-dimer testing may aid identifying low-risk patients, preventing overdiagnosis and reducing imaging costs. We conducted a retrospective, comparative analysis to assess cost savings that could be achieved by adopting different approaches determine most effective cut-off value cancer patients with suspected VTE, compared commonly used rule-out level...
The impact of impaired kidney function on outcomes and treatment benefits vitamin-K antagonists (VKA) versus direct oral anticoagulants (DOAC) in patients with atrial fibrillation (AF) has insufficiently been investigated randomized controlled studies (RCTs). Most registries are either biased due to incomplete enrolment consecutive large pharma industry sponsored registries, or short recruitment periods assessment important variables national registries.