A5053080218- Antibiotic Resistance in Bacteria
- Pharmaceutical and Antibiotic Environmental Impacts
- Enterobacteriaceae and Cronobacter Research
- Bacterial biofilms and quorum sensing
- Vibrio bacteria research studies
- Tuberculosis Research and Epidemiology
- Mycobacterium research and diagnosis
- Bacterial Identification and Susceptibility Testing
- Escherichia coli research studies
- Plant and Fungal Interactions Research
- Salmonella and Campylobacter epidemiology
- RNA and protein synthesis mechanisms
- Plant Disease Resistance and Genetics
- Infections and bacterial resistance
- Plant Virus Research Studies
- Genomics and Phylogenetic Studies
- Probiotics and Fermented Foods
- Antimicrobial Resistance in Staphylococcus
- Bacteriophages and microbial interactions
- Pneumonia and Respiratory Infections
- vaccines and immunoinformatics approaches
- Bacillus and Francisella bacterial research
- Plant Pathogenic Bacteria Studies
University of Buenos Aires
2016-2024
Consejo Nacional de Investigaciones Científicas y Técnicas
2016-2024
Instituto de Fisiología Vegetal
1997
National Agricultural Technology Institute
1997
Abstract Historically, the environment has been viewed as a passive deposit of antimicrobial resistance mechanisms, where bacteria show biological cost for maintenance these genes. Thus, in absence pressure, it is expected that they disappear from environmental bacterial communities. To test this scenario, we studied native IntI1 functionality 11 class 1 integron-positive strains distant genera collected cold and subtropical forests Argentina. We found natural competence successful...
Acinetobacter baumannii is one of the most important nosocomial pathogens able to rapidly develop extensive drug resistance. Here, we study role accessory genome in success globally disseminated clone 1 (GC1) with functional and genomic approaches. Comparative genomics was performed available GC1 genomes (n=106) against other A. high-risk sporadic clones. Genetic traits related were found common conserved along time as two novel regions plasticity, a CRISPR-Cas system acquired before clonal...
Acinetobacter baumannii is a Gram-negative bacterium increasingly implicated in hospital-acquired infections and outbreaks. Effective prevention control of such are commonly challenged by the frequent emergence multidrug-resistant strains. Here we introduce Ab-web (https://www.acinetobacterbaumannii.no), first online platform for sharing expertise on A. baumannii. species-centric knowledge hub, initially with 10 articles organized into two main sections, 'Overview' 'Topics', three themes,...
The worldwide dissemination of carbapenemase-producing Escherichia coli lineages belonging to high-risk clones poses a challenging public health menace. aim this work was investigate genomic features colonizing multidrug-resistant strain Klebsiella pneumoniae carbapenemase (KPC)-producing E. from our institution. Whole-genome sequencing done by Illumina MiSeq-I, and de novo assembly achieved using SPAdes. Resistome, mobilome, plasmids, virulome, integrons were analysed ResFinder, AMRFinder,...
Isolation of colistin- and carbapenem-resistant Klebsiella pneumoniae (CCR-Kp) is increasing in hospital settings worldwide, which related to increased morbidity, mortality healthcare costs. The aim this work was perform whole-genome sequencing (WGS), genomic phylogenetic analysis, conjugation assays an extensively drug-resistant (XDR) CCR-Kp isolate from Argentina. WGS strain KpS26 isolated a bloodstream infection performed using Illumina MiSeq-I, de novo assembly achieved SPAdes v.3.11. A...
According to the World Health Organization, carbapenem-resistant Enterobacteriaceae (CRE) belong highest priority group for development of new antibiotics. Argentina-WHONET data showed that Gram-negative resistance frequencies imipenem have been increasing since 2010 mostly in two CRE bacteria: Klebsiella pneumoniae and Enterobacter cloacae Complex (ECC). This scenario is mirrored our hospital. It known K. ECC coexist human body, but little about outcome these species producing KPC,...
Since the emergence of high-risk clones worldwide, constant investigations have been undertaken to comprehend molecular basis that led their prevalent dissemination in nosocomial settings over time. So far, complex and multifactorial genetic traits this type epidemic allowed only identification biomarkers with low specificity. A machine learning algorithm was able recognize unequivocally a biomarker for early accurate detection Acinetobacter baumannii global clone 1 (GC1), one most...
ABSTRACT Serratia marcescens SCH909 is a multidrug resistant strain isolated in 1988 harboring three class 1 integrons. We wondered if these integrons were retained over time and there other antimicrobial determinants contributing to its profile. Genomic analysis showed fourth resistance integron, Tn7 transposon with dfrA1-sat2-ybeA-ybfA-ybfB-ybgA gene cassettes the variable region. Insertion sequences involved genesis of novel composite transposons L4 subtype plasmid pSCH909, such as Tn6824...
The emergence of blaKPC-2 within nosocomial settings has become a major public health crisis worldwide. Our aim was to perform whole-genome sequencing (WGS) three KPC-producing Gram-negative bacilli (KPC-GNB) strains isolated from hospitalized patient identify acquired antimicrobial resistance genes (ARGs).WGS performed using Illumina MiSeq-I, and de novo assembly achieved SPAdes. Bioinformatics analysis done Resfinder, AMRFinder, ISFinder, plasmidSPAdes, PlasmidFinder, MOB-suite, PLSDB...
ABSTRACT Since the emergence of high-risk clones worldwide, constant investigations have been undertaken to comprehend molecular basis that led their prevalent dissemination in nosocomial settings over time. So far, complex and multifactorial genetic traits this type epidemic only allowed identification biomarkers with low specificity. A machine learning algorithm was able recognize unequivocally a biomarker for early accurate detection Acinetobacter baumannii Global Clone 1 (GC1), one most...