Josefina Campos
A5067061682- Salmonella and Campylobacter epidemiology
- Vibrio bacteria research studies
- Antibiotic Resistance in Bacteria
- Mycobacterium research and diagnosis
- Escherichia coli research studies
- Pneumonia and Respiratory Infections
- Tuberculosis Research and Epidemiology
- Viral gastroenteritis research and epidemiology
- Enterobacteriaceae and Cronobacter Research
- Listeria monocytogenes in Food Safety
- Plant Pathogenic Bacteria Studies
- Aquaculture disease management and microbiota
- Cassava research and cyanide
- Bacterial biofilms and quorum sensing
- Bacterial Identification and Susceptibility Testing
- Bacterial Infections and Vaccines
- Streptococcal Infections and Treatments
- Antimicrobial Resistance in Staphylococcus
- Viral Infections and Vectors
- Food Safety and Hygiene
- Neonatal and Maternal Infections
- SARS-CoV-2 and COVID-19 Research
- Reproductive tract infections research
- Identification and Quantification in Food
- Genomics and Phylogenetic Studies
Administración Nacional de Laboratorios e Institutos de Salud
2016-2025
University of Nizwa
2024
World Health Organization - Pakistan
2024
Başkent University Hospital
2023
Universitat de Barcelona
2023
Barcelona Institute for Global Health
2023
European Respiratory Society
2023
Örebro University
2021
Fundación Instituto Valenciano de Oncología
2010
The population of Salmonella enterica serovar Typhi (S. Typhi), the causative agent typhoid fever, exhibits limited DNA sequence variation, which complicates efforts to rationally discriminate individual isolates. Here we utilize data from whole-genome sequences (WGS) nearly 2,000 isolates sourced over 60 countries generate a robust genotyping scheme that is phylogenetically informative and compatible with range assays. These show that, exception rapidly disseminating H58 subclade (now...
Wave upon wave of disease The cholera pathogen, Vibrio cholerae , is considered to be ubiquitous in water systems, making the design eradication measures apparently fruitless. Nevertheless, local and global populations remain distinct. Now, Weill et al. Domman show that a surprising diversity between continents has been established. Latin America Africa bear different variants toxin with transmission dynamics ecological niches. data are not consistent establishment long-term reservoirs...
From November 2018 through February 2019, person-to-person transmission of Andes virus (ANDV) hantavirus pulmonary syndrome occurred in Chubut Province, Argentina, and resulted 34 confirmed infections 11 deaths. Understanding the genomic, epidemiologic, clinical characteristics ANDV is crucial to designing effective interventions.Clinical epidemiologic information was obtained by means patient report from public health centers. Serologic testing, contact-tracing, next-generation sequencing...
Abstract Background The Public Health Alliance for Genomic Epidemiology (PHA4GE) (https://pha4ge.org) is a global coalition that actively working to establish consensus standards, document and share best practices, improve the availability of critical bioinformatics tools resources, advocate greater openness, interoperability, accessibility, reproducibility in public health microbial bioinformatics. In face current pandemic, PHA4GE has identified need fit-for-purpose, open-source SARS-CoV-2...
Abstract The detection of antimicrobial resistance (AMR) markers directly from genomic or metagenomic data is becoming a standard clinical and public health procedure. This has resulted in the development number different bioinformatic AMR prediction tools. Although many may implement similar principles, these tools differ significantly their supported inputs, search algorithms, parameterisation, underlying reference databases. Each generates report detected genes variants distinct,...
Abstract Latin America and Caribbean (LAC) regions were an important epicenter of the COVID-19 pandemic SARS-CoV-2 evolution. Through Genomic Surveillance Regional Network (COVIGEN), LAC countries produced number genomic sequencing data that made possible enhanced surveillance capacity in Americas, paving way for characterization emerging variants helping to guide public health response. In this study we analyzed approximately 300,000 sequences generated between February 2020 March 2022 by...
The SARS-CoV-2 genome occupies a unique place in infection biology - it is the most highly sequenced on earth (making up over 20% of public sequencing datasets) with fine scale information sampling date and geography, has been subject to unprecedented intense analysis. As result, these phylogenetic data are an incredibly valuable resource for science health. However, vast majority was by tiling amplicons across full genome, amplicon schemes that changed pandemic as mutations viral interacted...
Abstract Background Aromatase ( CYP19A1 ) regulates estrogen biosynthesis. Polymorphisms in have been related to the pathogenesis of breast cancer (BC). Inhibition aromatase with letrozole constitutes best option for treating estrogen-dependent BC postmenopausal women. We evaluate a series polymorphisms and their effect on response neoadjuvant early BC. Methods analyzed 95 consecutive women stage II-III ER/PgR [+] treated letrozole. Response treatment was measured by radiology at 4 th month...
Shigella sonnei is a globally important diarrhoeal pathogen tracked through the surveillance network PulseNet Latin America and Caribbean (PNLA&C), which participates in International. PNLA&C laboratories use common molecular techniques to track pathogens causing foodborne illness. We aimed demonstrate possibility advantages of transitioning whole genome sequencing (WGS) for within existing networks across continent where S. endemic.We applied WGS representative archive isolates (n = 323)...
BackgroundWhole genome sequencing (WGS) is increasingly used for pathogen identification and surveillance.AimWe evaluated costs benefits of routine WGS through case studies at eight reference laboratories in Europe the Americas which conduct surveillance avian influenza (two laboratories), human (one laboratory) food-borne pathogens (five laboratories).MethodsThe evaluation focused on institutional perspective, i.e. 'investment case' implementing compared with conventional methods, based...
Staphylococcus aureus remains one of the leading causes infections worldwide and a common cause bacteraemia. However, studies documenting epidemiology S. in South America using genomics are scarce. We hereby report on largest genomic study to date both methicillin-resistant (MRSA) methicillin-susceptible (MSSA) America, conducted by StaphNET-SA network. characterised 404 genomes recovered from prospective observational bacteraemia 58 hospitals Argentina, Bolivia, Brazil, Paraguay Uruguay...
Shiga toxin-producing Escherchia coli (STEC) O157:H7 is a zoonotic pathogen that causes numerous food and waterborne disease outbreaks. It globally distributed, but its origin the temporal sequence of geographical spread are unknown.We analyzed whole-genome sequencing data 757 isolates from 4 continents, performed pan-genome analysis to identify core genome and, this, extracted single-nucleotide polymorphisms. A timed phylogeographic was on subset investigate worldwide spread.The common...
Members of the genus Phytobacter (order Enterobacterales) are isolated from natural environment and clinical settings. Identification strains based on biochemical characteristics is complicated due to taxonomic confusion, they often misidentified by automated identification systems in laboratories. In this study we describe first three cases associated with spp. reported Argentina. We identification, molecular analysis using whole genome sequencing potential relevance.
Group B Streptococcus (GBS) is a commensal bacterium that can cause severe infections in infants and adults with comorbidities. Resistance reduced susceptibility to antibiotics are continually on the rise, vaccines remain development. Prophages have been reported contribute GBS evolution pathogenicity. However, no studies available date prophage contribution epidemiology of isolates from humans South America. In context an Argentinian multicentric study, we had previously phenotypically...
<title>Abstract</title> Background: Tuberculosis (TB), caused by the intracellular bacterium <italic>Mycobacterium tuberculosis</italic> (Mtb), remains a significant global health challenge, with Mtb being second leading infectious killer worldwide, following COVID-19. Despite over century of research, disease continues to pose major threat, an estimated one-fourth population latently infected. According World Health Organization (WHO), approximately 1.25 million deaths were attributed TB in...
In order to control and eradicate epidemic cholera, we need understand how epidemics begin, they spread, decline eventually end. This requires extensive sampling of disease over time, alongside the background endemic that may exist concurrently with epidemic. The unique circumstances surrounding Argentinian cholera 1992-1998 presented an opportunity do this. Here, use 490 V. cholerae genome sequences characterise variation within, between, cholerae. We show that, during epidemic, invariant...
Extraintestinal pathogenic Escherichia coli (ExPEC) causes infections outside the intestine. Particular ExPEC clones, such as clonal complex (CC)/sequence type (ST)131, have been known to sequentially accumulate antimicrobial resistance that starts with chromosomal mutations against fluoroquinolones, followed acquisition of blaCTX-M-15 and, more recently, carbapenemases. Here we aimed investigate distribution global epidemic clones carbapenemase-producing from Argentina in representative...
Foodborne diseases and other enteric infections often occur as outbreaks cause morbidity mortality all over the world. In Perú, they represent a serious public health problem, are caused by great variety of infectious agents. For epidemiological research, wide array typification methods used. One most important tools for molecular subtyping bacterial pathogens is Pulsed Field Gel Electrophoresis (PFGE), which highly precise method that allows discrimination between different isolates...
The Public Health Alliance for Genomic Epidemiology (PHA4GE) (https://pha4ge.org) is a global coalition that actively working to establish consensus standards, document and share best practices, improve the availability of critical bioinformatic tools resources, advocate greater openness, interoperability, accessibility reproducibility in public health microbial bioinformatics. In face current pandemic, PHA4GE has identified clear present need fit-for-purpose, open source SARS-CoV-2...