A5006019160- SARS-CoV-2 and COVID-19 Research
- Genetic Neurodegenerative Diseases
- Prenatal Screening and Diagnostics
- Viral Infections and Outbreaks Research
- Assisted Reproductive Technology and Twin Pregnancy
- Monoclonal and Polyclonal Antibodies Research
- Parkinson's Disease Mechanisms and Treatments
- Cerebrovascular and genetic disorders
- PI3K/AKT/mTOR signaling in cancer
- Animal Virus Infections Studies
- Protein Kinase Regulation and GTPase Signaling
- Advanced biosensing and bioanalysis techniques
- Ubiquitin and proteasome pathways
- Neurological disorders and treatments
- Viral Infections and Vectors
- COVID-19 Clinical Research Studies
- Genetics and Neurodevelopmental Disorders
- Genomic variations and chromosomal abnormalities
- Cellular transport and secretion
- Mitochondrial Function and Pathology
- SARS-CoV-2 detection and testing
- Neurological diseases and metabolism
- Retinal Development and Disorders
- Cleft Lip and Palate Research
- Breastfeeding Practices and Influences
Administración Nacional de Laboratorios e Institutos de Salud
2011-2024
Ministerio de Salud
2021
Consejo Nacional de Investigaciones Científicas y Técnicas
2001-2016
University of Buenos Aires
2011-2015
Hospital de Clínicas "José de San Martín"
2011-2012
Fundación Instituto Leloir
2001-2011
Radboud University Nijmegen
2007
Radboud University Medical Center
2007
Halitus Instituto Médico
2007
Abstract Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has infected at least 180 million people since its identification as the cause of current COVID-19 pandemic. The rapid pace vaccine development resulted in multiple vaccines already use worldwide. contemporaneous emergence SARS-CoV-2 ‘variants concern’ (VOC) across diverse geographic locales underscores need to monitor efficacy being administered globally. All WHO designated VOC carry spike (S) polymorphisms thought enable...
From November 2018 through February 2019, person-to-person transmission of Andes virus (ANDV) hantavirus pulmonary syndrome occurred in Chubut Province, Argentina, and resulted 34 confirmed infections 11 deaths. Understanding the genomic, epidemiologic, clinical characteristics ANDV is crucial to designing effective interventions.Clinical epidemiologic information was obtained by means patient report from public health centers. Serologic testing, contact-tracing, next-generation sequencing...
Gam-COVID-Vac (SPUTNIK V) has been granted emergency use authorization in 70 nations and administered to millions worldwide. However, there are very few peer-reviewed studies describing its effects. Independent reports regarding safety effectiveness could accelerate the final approval by WHO. We aimed study long-term humoral immune response naïve previously infected volunteers who received SPUTNIK V.Humoral responses, assayed anti-SARS-CoV-2-spike-RBD IgG ELISA neutralization assays, were...
Beckwith-Wiedemann syndrome (BWS) is an overgrowth characterized by excessive prenatal and postnatal growth, macrosomia, macroglossia, hemihyperplasia. The molecular basis of this complex heterogeneous, involving genes located at 11p15.5. BWS correlated with assisted reproductive techniques. in individuals born following techniques has been found to occur four nine times higher compared children after spontaneous conception. Here, we report a series 187 patients either or conceived...
Abstract We report a case of Argentine hemorrhagic fever diagnosed in woman Belgium who traveled from disease-endemic area. Patient management included supportive care and combination therapy with ribavirin favipiravir. Of 137 potential contacts, including friends, relatives, healthcare laboratory workers, none showed development clinical symptoms this disease.
ABSTRACT The novel pandemic betacoronavirus, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has infected at least 120 million people since its identification as the cause of a December 2019 viral pneumonia outbreak in Wuhan, China. Despite unprecedented pace vaccine development, with six vaccines already use worldwide, emergence SARS-CoV-2 ‘variants concern’ (VOC) across diverse geographic locales suggests herd immunity may fail to eliminate virus. All three officially...
The novel pandemic betacoronavirus, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has infected at least 120 million people since its identification as the cause of a December 2019 viral pneumonia outbreak in Wuhan, China1,2. Despite unprecedented pace vaccine development, with six vaccines already use worldwide, emergence SARS-CoV-2 'variants concern' (VOC) across diverse geographic locales have prompted re-evaluation strategies to achieve universal vaccination3. All three...
Introduction Antibodies against the SARS-CoV-2 spike protein are a critical immune determinant for protection virus. While virus neutralization is key function of spike-specific antibodies, antibodies also mediate Fc-dependent activities that can play role in or pathogenesis. Methods This study characterized serum antibody responses elicited after two doses heterologous adenovirus-vectored (Ad26/ Ad5) vaccines. Results Vaccine-induced binding titers and Fc-mediated functions decreased over...
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PTEN is a critical gene involved in the regulation of many cellular processes. The product this has dual phosphatase activity and able to dephosphorylate 5′ end phosphatidylinositol (3,4,5)-trisphosphate. Within nucleus, protein been associated with expression genes, although mechanism remains unclear. In paper, two specific oligonucleotide aptamers were developed selected, using SELEX procedure, according their ability detect different subcellular compartments neurons. While one aptamer was...
<h3>Introduction</h3> The huntingtin protein (HTT) has 3144 amino acids and undergoes numerous post-translational modifications. Its amino-terminal end is highly conserved seems to be involved in huntingtin-huntingtin interactions. Several antibodies have been developed for detecting the domain of HTT (including N17, CAG tract polyProline region), but few shown detect endogeneous expression using histological means. <h3>Objectives</h3> To develop "custom-made" aptamers that can used neuritic...
Objective The purpose of this investigation was to study the social environment families children with different types nonsyndromic oral clefts (OC) and compare these groups a control population without clefts. Design compared three cleft group using Moos Family Environment Scale, which examines cohesion, expressiveness, conflict, independence, achievement-orientation, intellectual-cultural orientation, active-recreational moral-religious emphasis, organization, control. Setting All parents...
Antibodies are the most used technological tool in histochemistry. However, even with monoclonal antibodies, their standardization is difficult due to variation of biological systems as well variability affinity and amplification signal arising from secondary peroxidase detection systems. In this article we combined two synthetic molecules facilitate a protocol protein markers histological sections. The first molecule was an aptamer, 50-base single-stranded DNA fragment, which recognizes...
OBJECTIVE: To establish whether four patients who had been diagnosed with progressive supranuclear palsy (PSP) might exhibit lipid trafficking abnormalities, and therefore actually represent cases of misdiagnosed late-onset Niemann-Pick disease type C (NP-C). BACKGROUND: PSP is a neurodegenerative characterized by gait disturbance, vertical gaze (VSGP), akinetic-rigid syndrome levodopa unresponsiveness, frontotemporal dementia premature death. Adult-onset NP-C has several symptoms in common...
Perandones C, Pellene LA, Giugni JC, Calvo DS, RainaGB, Cuevas SM, Mata IF, Zabetian CP, Caputo M,Corach D, Micheli FE and Radrizzani M. Exp Neurobiol 2015;24:173-5. https://doi.org/10.5607/en.2015.24.2.173
Background: Gam-COVID-Vac, also known as SPUTNIK V, is the first COVID-19 vaccine registered, has emergency use authorization in 70 nations, and been administered to millions worldwide. However, there are very few peer-reviewed studies describing its effects. As independent reports begin be published, a more accurate picture regarding safety effectiveness could accelerate approval by WHO.Methods: An ELISA that detects anti-SARS-CoV-2-spike-RBD IgG was used, both transversal longitudinal...
Abstract Since its emergence in 2019, SARS-CoV-2 has infected millions of people and several vaccines have been approved for clinical use worldwide. Antibodies against the spike protein are a critical immune determinant protection this virus. While virus neutralization is key function spike-specific antibodies, antibodies also mediate Fc-dependent activities that can play role or pathogenesis. This study compared Fc properties functions anti-spike elicited by Pfizer/BioNtech Moderna mRNA...