A5040515534- Antibiotic Resistance in Bacteria
- Vibrio bacteria research studies
- Bacterial biofilms and quorum sensing
- Genomics and Phylogenetic Studies
- Antimicrobial Resistance in Staphylococcus
- Plant Pathogenic Bacteria Studies
- Bacterial Identification and Susceptibility Testing
- Bacteriophages and microbial interactions
- Escherichia coli research studies
- Vector-borne infectious diseases
- Insect symbiosis and bacterial influences
- Reproductive tract infections research
- Bacterial Genetics and Biotechnology
- Bacterial Infections and Vaccines
- Salmonella and Campylobacter epidemiology
- Microbial Metabolism and Applications
- Yersinia bacterium, plague, ectoparasites research
- Legume Nitrogen Fixing Symbiosis
- Microbial infections and disease research
- Viral Infections and Vectors
- Plant nutrient uptake and metabolism
- Infections and bacterial resistance
- Syphilis Diagnosis and Treatment
- Evolution and Genetic Dynamics
- Aquaculture disease management and microbiota
Universidad Nacional Autónoma de México
2016-2025
Universidad Autónoma del Estado de Morelos
2020-2024
Ottawa Research and Development Centre
2024
University of Manitoba
2024
Justus-Liebig-Universität Gießen
2024
Agriculture and Agri-Food Canada
2024
National Institute of Genomic Medicine
2014
University of Bath
2011-2013
The widespread use of antibiotics in association with high-density clinical care has driven the emergence drug-resistant bacteria that are adapted to thrive hospitalized patients. Of particular concern globally disseminated methicillin-resistant Staphylococcus aureus (MRSA) clones cause outbreaks and epidemics associated health care. most rapidly spreading tenacious health-care-associated clone Europe currently is EMRSA-15, which was first detected UK early 1990s subsequently spread...
ABSTRACT The implementation of routine whole-genome sequencing (WGS) promises to transform our ability monitor the emergence and spread bacterial pathogens. Here we combined WGS data from 308 invasive Staphylococcus aureus isolates corresponding a pan-European population snapshot, with epidemiological resistance data. Geospatial visualization is made possible by generic software tool designed for public health purposes that available at project URL (...
Here we discuss the evolution of northern Australian Staphylococcus aureus isolate MSHR1132 genome. belongs to divergent clonal complex 75 lineage. The average nucleotide divergence between orthologous genes in and typical S. is approximately sevenfold greater than maximum observed this species date. has a small accessory genome, which includes well-characterized genomic islands, νSAα νSaβ, suggesting that these elements were acquired well before expansion population. Other mobile show...
Abstract Background Next-generation sequencing (NGS) is a powerful tool for understanding both patterns of descent over time and space (phylogeography) the molecular processes underpinning genome divergence in pathogenic bacteria. Here, we describe synthesis between these perspectives by employing recently developed Bayesian approach, BRATNextGen, detecting recombination on an expanded NGS dataset globally disseminated methicillin-resistant Staphylococcus aureus (MRSA) clone ST239. Results...
Clonal complex 5 methicillin-resistant Staphylococcus aureus (CC5-MRSA) includes multiple prevalent clones that cause hospital-associated infections in the Western Hemisphere. Here, we present a phylogenomic study of these MRSA to reveal their phylogeny, spatial and temporal population structure, evolution selected traits. We studied 598 genome sequences, including 409 newly generated from 11 countries Central, North, South America, references Asia Europe. An early-branching CC5-Basal clade...
Acinetobacter baumannii is an emergent bacterial pathogen that provokes many types of infections in hospitals around the world. The genome this organism consists a chromosome and plasmids. These plasmids vary over wide size range them have been linked to acquisition antibiotic-resistance genes. Our bioinformatic analyses indicate A. belong small number plasmid lineages. general structure these lineages seems be very stable not only genes involved maintenance functions but gene sets encoding...
Phages and prophages are one of the principal modulators microbial populations. However, much their diversity is still poorly understood. Here, we extracted 33,624 from 13,713 complete prokaryotic genomes to explore prophage relationships with host. Our results reveal that were present in 75% studied. In addition, Enterobacterales significantly enriched prophages. We also found pathogens a significant reservoir Finally, determined relatedness range genomic hosts delimited by evolutionary...
Introduction Prophages play a crucial role in the genomic diversity of Acinetobacter baumannii , contributing to its pathogenicity and adaptation. Methods In this study, we induced sequenced seven prophages from five isolates A. . These were analyzed with 967 identified various worldwide, plus 21 genomes other phages infecting previously reported NCBI. To have an overview populations Results Our analysis revealed 13 major prophage clusters within isolates. Notably, belonging Vieuvirus genus...
The development of next-generation sequencing platforms is set to reveal an unprecedented level detail on short-term molecular evolutionary processes in bacteria. Here we re-analyse genome-wide single nucleotide polymorphism (SNP) datasets for recently emerged clones methicillin resistant Staphylococcus aureus (MRSA) and Clostridium difficile. We note a highly significant enrichment synonymous SNPs those genes which have been affected by recombination, i.e. mobile elements designated...
Neisseria gonorrhoeae is the causative agent of gonorrhea, a sexually transmitted infection (STI) major importance. As result antibiotic resistance, there are now limited options for treating patients. We collected draft genome sequence data and associated metadata on 76 N. strains from around globe searched known determinants antibiotics resistance within strains. The population structure evolutionary forces pathogen were analyzed. Our results indicated cosmopolitan gonoccocal mainly made...
The Borrelia burgdorferi sensu lato (s.l.) species complex consists of tick-transmitted bacteria and currently comprises approximately 20 named proposed genospecies some which are known to cause Lyme Borreliosis. Species have been defined via genetic distances ecological niches they occupy. Understanding the evolutionary relationship is fundamental explaining patterns speciation. This in turn forms a crucial basis frame testable hypotheses concerning underlying processes including host...
Abstract The Gram-negative Acinetobacter genus has several species of clear medical relevance. Many fully sequenced genomes belonging to the have been published in recent years; however, there not a attempt infer evolutionary history with that vast amount information. Here, through phylogenomic approach, we established most up-to-date view relationships within this and highlighted cases poor classification, especially for very closely related calcoaceticus–Acinetobacter baumannii complex...
Rejection (nomen rejiciendum) of the name Borreliella and all new combinations therein is being requested on grounds risk to human health patient safety (Principle 1, subprinciple 2 Rule 56a) violation aim for stability names, avoid useless creation names 1 3) that should not be changed without sufficient reason 9 International Code Nomenclature Prokaryotes).
Antimicrobial resistance (AR) is a major global threat to public health. Understanding the population dynamics of AR critical restrain and control this issue. However, no study has provided picture whole resistome
Acinetobacter baumannii is one the most worrisome nosocomial pathogens, which has long been considered almost mainly as a hospital-associated bacterium. There have some studies about animal and environmental isolates over last decade. However, little effort made to determine if this pathogen dwells in grass. Here, we aim evolutionary relationships antibiotic resistance of clones A. sampled from grass major human international clones. Two hundred forty genomes were total four different...
is an opportunistic human and animal pathogen severely understudied. Here, we conducted the largest genomic epidemiological study on this to date. Our data show that bacterium has spread globally. Also, found some non-human isolates are not well differentiated from one another, implying transmission between clinical non-clinical, settings. Remarkably, but also have clinically important antibiotic resistance genes, of these genes located in plasmids. Given results, put forward
Fabaceae (legumes) is one of the largest families flowering plants, and some members are important crops. In contrast to what we know about their great diversity or economic importance, our knowledge at genomic level chloroplast genomes (cpDNAs plastomes) for these crops limited. We sequenced complete genome common bean (Phaseolus vulgari s cv. Negro Jamapa) chloroplast. The plastome P. vulgaris a 150,285 bp circular molecule. It has gene content similar that other legume plastomes, but...
ABSTRACT Vibrio parahaemolyticus is a seafood-borne pathogenic bacterium that major cause of gastroenteritis worldwide. We investigated the genetic and evolutionary relationships 101 V. isolates originating from clinical, human carrier, various environmental seafood production sources in Thailand using multilocus sequence analysis. The were recovered clinical samples ( n = 15), healthy carriers 18), types fresh frozen shrimp 16), fresh-farmed tissue farm water 16). Phylogenetic analysis...
Genome sequencing has been useful to gain an understanding of bacterial evolution. It used for studying the phylogeography and/or impact mutation and recombination on populations. However, it rarely study gene turnover at microevolutionary scales. Here, we sequenced Mexican strains human pathogen Acinetobacter baumannii sampled from same locale over a 3 year period obtain insights into dynamics content variability. We found that A. population was recently founded emerging due rapid clonal...
Objective To describe the clinical features, outcomes, and molecular epidemiology of an outbreak multidrug resistant (MDR) A. baumannii. Methods We performed a retrospective analysis all MDR baumannii isolates recovered during from 2011 to 2015 in tertiary care cancer hospital. Cases were classified as colonized or infected. determined sequence types following Bartual scheme plasmid profiles. Results There 106 strains isolated study period. Sixty-six (62.3%) considered infection 40 (37.7%)...
is a Gram-negative, opportunistic pathogen that causes infections in the immunocompromised. With high incidence of muti-drug resistance, carbapenem-resistant
This work centres on the genomic comparisons of two closely-related nitrogen-fixing symbiotic bacteria, Rhizobium leguminosarum biovar viciae 3841 and etli CFN42. These strains maintain a stable core that is also common to other rhizobia species plus very variable significant accessory component. The chromosomes are highly syntenic, whereas plasmids related by fewer syntenic blocks have mosaic structures. pairs p42f-pRL12, p42e-pRL11 p42b-pRL9 as well large parts p42c with pRL10 shown be...
Understanding the spread of infectious diseases is crucial for implementing effective control measures. For this, it important to obtain information on contemporary population structure a disease agent and infer evolutionary processes that may have shaped it. Here, we investigate continental scale Borrelia burgdorferi, causative Lyme borreliosis (LB), tick-borne disease, in North America. We test hypothesis observed congruent with recent expansions these were preceded by bottlenecks mostly...