A5030902787- Pneumonia and Respiratory Infections
- Streptococcal Infections and Treatments
- Bacterial Infections and Vaccines
- Respiratory viral infections research
- Antimicrobial Resistance in Staphylococcus
- Bacterial biofilms and quorum sensing
- Bacterial Identification and Susceptibility Testing
- Mosquito-borne diseases and control
- Viral Infections and Vectors
- Pneumocystis jirovecii pneumonia detection and treatment
- Antibiotic Use and Resistance
- Urinary Tract Infections Management
- Antibiotics Pharmacokinetics and Efficacy
- Neonatal and Maternal Infections
- Vector-Borne Animal Diseases
- Pediatric Urology and Nephrology Studies
- Reproductive tract infections research
- Influenza Virus Research Studies
- Virology and Viral Diseases
- Child and Adolescent Health
- Antibiotic Resistance in Bacteria
- Vaccine Coverage and Hesitancy
- Vector-borne infectious diseases
- Metabolism and Genetic Disorders
- Clostridium difficile and Clostridium perfringens research
Instituto Nacional de Salud Pública
2015-2025
University of Puerto Rico-Mayaguez
2023
Harvard University
2021
Boston Children's Hospital
2021
Florida State University
2021
National Institute of Public Health
2015
Sanofi (Mexico)
2010
Hospital Doctor Hernán Henríquez Aravena
2010
Universidad de La Frontera
2010
Instituto Adolfo Lutz
1998-2009
Streptococcus pneumoniae is a leading cause of fatal bacterial pneumonia in young children. Pneumococcal polysaccharide vaccines have not been promoted for use children because many constituent serotypes are immunogenic < 2 years old. Conjugating pneumococcal epitopes to protein carrier would likely increase vaccine immunogenicity We reviewed published and unpublished serotype serogroup data from 16 countries on 6 continents determine geographic temporal differences distribution sterile site...
Clonal complex 5 methicillin-resistant Staphylococcus aureus (CC5-MRSA) includes multiple prevalent clones that cause hospital-associated infections in the Western Hemisphere. Here, we present a phylogenomic study of these MRSA to reveal their phylogeny, spatial and temporal population structure, evolution selected traits. We studied 598 genome sequences, including 409 newly generated from 11 countries Central, North, South America, references Asia Europe. An early-branching CC5-Basal clade...
Background. Since 1993 the Pan American Health Organization has coordinated a surveillance network with National Reference Laboratories of Argentina, Brazil, Chile, Colombia, Mexico and Uruguay aimed at monitoring capsular types antimicrobial susceptibility Streptococcus pneumoniae causing invasive disease in children <6 years age. Methods. The system included 6 age younger caused by S. pneumoniae. identification, typing to penicillin isolates were conducted using common protocol, based on...
ABSTRACT Four hundred ninety-nine methicillin-resistant Staphylococcus aureus (MRSA) isolates recovered from 1996 to 1998 22 hospitals in five countries of Latin America—Argentina, Brazil, Chile, Uruguay and Mexico—were examined for antimicrobial susceptibility clonal type order define the endemic clones those hospitals. The hybridization Cla I restriction digests with mecA - Tn 554 -specific DNA probes combined pulsed-field gel electrophoresis chromosomal Sma ( I- :: I-Tn ::PFGE types)...
Protein-polysaccharide conjugate vaccines against Streptococcus pneumoniae promise to be an effective public health intervention for children, especially in era of increasing antimicrobial resistance. To characterize the distribution capsular types Latin America, surveillance invasive pneumococcal infection children < or = 5 years age was done six countries between February 1993 and April 1996. Fifty percent 1,649 sterile-site isolates were from with pneumonia, 52% isolated blood. The 15...
Background: For the last 14 years Pan American Health Organization has been promoting surveillance of invasive pneumococcal disease in Latin children for better understanding tendencies regarding capsular types circulation each country and susceptibility to antimicrobials. Methods: Laboratory-based data from 10 countries collected 2000 2005 were analyzed, including serotype distribution beta-lactam antibiotics. Results: Although 61 different identified during 6-year surveillance, 13...
ABSTRACT Between 1997 and 2000 a single multidrug-susceptible methicillin-resistant Staphylococcus aureus clone, M (sequence type 30 [ST30]-staphylococcal cassette chromosome mec [SCC ] IV), was present in pediatric hospital Mexico City, Mexico. In 2001 the international multidrug-resistant New York-Japan clone (ST5-SCC II) introduced into hospital, completely replacing by 2002.
Background: Surveillance of antimicrobial resistance (AMR) requires an international approach with national and local strategies. Our aim was to summarize a retrospective 10-year report antibiotic gram-positive gram-negative bacteria in Mexico. Methods: A total 46 centers from 22 states Mexico participated. Databases AMR January 2009 December 2018 were included for most species. The period divided into five 2-year periods. Results: For Staphylococcus aureus, decrease all specimens observed...
Aedes aegypti, eradicated from Argentina in 1963, has now reinfested the country as far south Buenos Aires. In 1997, four persons with travel histories to Brazil, Ecuador, or Venezuela had confirmed dengue, and surveillance for indigenous transmission allowed detection of 19 dengue cases Salta Province. These are first since 1916 represent a new southern extension virus.
The Pan American Health Organization (PAHO) has conducted a study of Streptococcus pneumoniae in six Latin-American countries: Argentina, Brazil, Chile, Colombia, Mexico, and Uruguay. Sterile site isolates from children aged < or =5 years showing clinical symptoms pneumonia (as defined by the criteria WHO), meningitis, sepsis bacteremia (without infectious foci), arthritis, peritonitis were source most invasive pneumococcal collected between end 1993 1996 participating countries. Partial...
ABSTRACT Thirty-one strains of Klebsiella pneumoniae (including 10 duplicates) from 21 septicemic pediatric patients (age, <2 months) were studied during a 4-month period (June to October 1996) in which the fatality rate was 62% (13 21). These isolates identified by API 20E system yielded same biotype. Pulsed-field gel electrophoresis experiments revealed clone 31 strains. The multidrug-resistant but still susceptible ciprofloxacin, imipenem, and cefoxitin. A 135-kb plasmid harbored all...
Introduction The methicillin-resistant Staphylococcus aureus (MRSA) genome varies by geographical location. This study aims to determine the genomic characteristics of MRSA using whole-genome sequencing (WGS) data from medical centers in Mexico and explore associations between antimicrobial resistance genes virulence factors. Methods included 27 clinical isolates collected sterile sites at eight 2022 2023. Antibiotic susceptibility testing was performed VITEK 2. In addition, WGS a NovaSeq...
Aedes albifasciatus (Macquart) has been considered a potential vector of western equine encephalitis (WEE) virus in Argentina because it found naturally infected, is susceptible to infection per os, and its distribution feeding habits are compatible with those an epizootic epidemic vector. Ae. females collected the vicinity Cordoba, Argentina, were highly WEE perorally (ID50 <0.5 Vero cell plaque-forming units) when fed on viremic chicks. Virus transmission trials done 9 16 d after by...
ABSTRACT We have recently developed a rapid pneumococcal serotyping method called “multibead assay” (J. Yu et al., J. Clin. Microbiol. 43: 156-162, 2005) based on multiplexed immunoassay for capsular polysaccharides in lysates of cultures. The multibead assay can identify 36 serotypes (1, 2, 3, 4, 5, 6A, 6B, 7A/7F, 8, 9L/9N, 9V, 10A/10B/39/33C, 11A/11D/11F, 12A/12B/12F, 14, 15B/5C, 17F, 18C, 19A, 19F, 20, 22A/22F, 23F, and 33A/33F). More than 90% the U.S. isolates express one these B....
Comparative studies are described on the virulence of western equine encephalomyelitis (WEE) complex viruses for mice. Three epizootic WEE virus strains (McMillan, Cba 87, and CIV 180) five enzootic (Highlands J [HJ], Y62-33, Aura, Fort Morgan [FM], AG80-646) were examined. The neurovirulence neuroinvasiveness these adult mice established correlated with viremia replication in brain tissue. Adult inoculated intraperitoneally showed differential responses that corresponded to epidemiologic...