A5014144185- Pneumonia and Respiratory Infections
- Bacterial Infections and Vaccines
- Bacterial Identification and Susceptibility Testing
- Respiratory viral infections research
- Infective Endocarditis Diagnosis and Management
- Microbial infections and disease research
- Tuberculosis Research and Epidemiology
- Streptococcal Infections and Treatments
- Pneumocystis jirovecii pneumonia detection and treatment
- Craniofacial Disorders and Treatments
- Antimicrobial Resistance in Staphylococcus
- Influenza Virus Research Studies
- Antibiotic Resistance in Bacteria
- Myasthenia Gravis and Thymoma
- Child and Adolescent Health
- Cerebrospinal fluid and hydrocephalus
- Child Abuse and Related Trauma
- Infectious Diseases and Tuberculosis
Administración Nacional de Laboratorios e Institutos de Salud
2013-2025
The introduction of pneumococcal conjugate vaccination (PCV) into the Argentinian Childhood National Immunization Program in 2012 marked a significant milestone public health. Our study aims to assess impact this intervention on meningitis cases, serotype distribution, and antimicrobial resistance among pediatric populations from 2013 2023. Specifically, we compared early post-PCV period (2013–2014) late (2022–2023). A total 333 isolates were analyzed between Gold standard serotyping was...
Streptococcus pneumoniae is a major cause of severe invasive disease associated with high mortality and morbidity worldwide. To identify the serotypes most commonly infection in adults Argentina, 791 pneumococcal isolates from 56 hospitals belonging to 16 provinces Buenos Aires city were serotyped. The submitted as part National Surveillance Program for adults, which started 2013. Serotypes 3, 8, 12F, 7F 1 prevalent among adult patients. During study period there was no significant...
Meningococcal (Neisseria meningitidis) serogroup B (MenB) strain antigens are diverse and a limited number of strains can be evaluated using the human serum bactericidal antibody (hSBA) assay. The genetic Antigen Typing System (gMATS) was developed to predict likelihood coverage for large numbers isolates by 4CMenB vaccine, which includes Neisseria adhesin A (NadA), Neisserial Heparin-Binding (NHBA), factor H-binding protein (fHbp), Porin (PorA). In this study, we characterized whole-genome...
The incorporation of Haemophilus influenzae type b (Hib) vaccine into the Argentine National Immunization Program in 1998 resulted a dramatic decrease incidence invasive disease due to this serotype. We assessed 1405 H. (Hi) isolates causing infections referred Reference Laboratory between 2011 and 2019. Non-encapsulated Hi were most common strains (44.5%), followed by types (41.1%) (10.0%). Significant increase proportion was observed, from 31.2% 2011, 50% 2015, correlating with peak rate,...
Invasive meningococcal disease (IMD) is a life-threatening caused by serogroups A, B, C, W, X, and Y, of which B W are most common in Argentina. The 4-component serogroup (4CMenB) vaccine contains three purified recombinant protein antigens (Neisseria adhesin A [NadA], factor H binding [fHbp], Neisserial Heparin Binding Antigen [NHBA]) outer membrane vesicles (OMV), derived from the New Zealand epidemic strain Porin 1.4. These present conserved strains that belong to other serogroups. In...
The introduction of the Haemophilus influenzae type b vaccine in immunization programs many countries has greatly reduced this invasive disease and carriage caused by serotype, also increasing other capsular types non-capsular isolations. There were 313 isolations H. under study, which recovered from a sterile site coming pediatric adult patients carrying disease. Patients treated at 90 different hospitals belonging to Red Nacional de Laboratorios para Meningitis e Infecciones Respiratorias...
Background: Streptococcus pneumoniae, a prominent human pathogen linked to various systemic diseases, includes non-typeable pneumococci marked by the absence of detectable capsule. However, majority invasive infections are attributed encapsulated strains. This case report details first documented instance disease caused S. pneumoniae in Argentina since 2017. Case Presentation: A 19-year-old woman presented with hemorrhagic injuries chronic oral mucosa irritation. Subsequent hospitalization...
Background. Streptococcus pneumoniae , a prominent human pathogen linked to various systemic diseases, includes non-typeable pneumococci marked by the absence of detectable capsule. However, majority invasive infections are attributed encapsulated strains. This case report details first documented instance disease caused S. in Argentina since 2017. Case Presentation. A 19-year-old woman presented with haemorrhagic injuries chronic oral mucosa irritation. Subsequent hospitalization revealed...
The introduction of pneumococcal conjugate vaccination (PCV) into the Argentinian Childhood National Immunization Program in 2012 marked a significant milestone public health. Our study aims to assess impact this intervention on meningitis cases, serotype distribution, and antimicrobial resistance among paediatric populations from 2013 2023. Specifically, we compared early post-PCV period (2013–2014) late (2022–2023). A total 333 isolates were analyzed between Gold standard serotyping was...
Se presenta el caso de un absceso cerebral causado por Haemophilus influenzae tipo e, en paciente 12 años con síndrome Apert. El Apert se caracteriza cierre prematuro las suturas craneales. En 2010, presentó traumatismo craneano región frontal, fractura y fístula líquido cefalorraquídeo. febrero 2013 consultó fiebre, vómitos convulsión tónica clónica generalizada, deterioro progresivo del sensorio. La tomografía axial computarizada mostró una lesión frontal derecha, edema perilesional, leve...
Abstract Laboratory surveillance of Streptococcus pneumoniae serotypes is crucial for the successful implementation vaccines to prevent invasive pneumococcal diseases. The reference method serotyping Quellung reaction, which labor-intensive and expensive. In last few years, introduction MALDI-TOF MS into microbiology laboratory has been revolutionary. brief, this new technology compares protein profiles by generating spectra based on m/z ratio. We evaluated performance typing S. isolates...
Abstract Laboratory surveillance of Streptococcus pneumoniae serotypes is crucial for the successful implementation vaccines to prevent invasive pneumococcal diseases. The reference method serotyping Quellung reaction, which labor-intensive and expensive. In last few years, introduction MALDI-TOF MS into microbiology laboratory has been revolutionary. brief, this new technology compares protein profiles by generating spectra based on m/z ratio. We evaluated performance typing S. isolates...
This case report describes a bacteremic pneumococcal pneumonia episode involving the first non-typeable (NT) Streptococcus pneumoniae causing invasive disease, according to national epidemiology in last five years and fulfil characterization of S. isolate, including its genetic background.
Laboratory surveillance of Streptococcus pneumoniae serotypes plays a crucial role in effectively implementing vaccines to prevent invasive pneumococcal diseases. The conventional method serotyping, known as the Quellung reaction, is both time-consuming and expensive. However, emergence MALDI-TOF MS technology has revolutionized microbiology laboratories by enabling rapid cost-effective serotyping based on protein profiles.In this study, we aimed investigate viability utilizing an adjunctive...