A5085217947- Antibiotic Resistance in Bacteria
- Bacterial biofilms and quorum sensing
- Clostridium difficile and Clostridium perfringens research
- Bacterial Identification and Susceptibility Testing
- Antimicrobial Resistance in Staphylococcus
- Infections and bacterial resistance
- Nosocomial Infections in ICU
- Tuberculosis Research and Epidemiology
- Microscopic Colitis
- Pneumonia and Respiratory Infections
- Streptococcal Infections and Treatments
- Gut microbiota and health
- Mycobacterium research and diagnosis
- Viral gastroenteritis research and epidemiology
- Antibiotic Use and Resistance
- Infectious Diseases and Tuberculosis
- Pharmaceutical and Antibiotic Environmental Impacts
- Gastrointestinal motility and disorders
- COVID-19 diagnosis using AI
- Vaccine Coverage and Hesitancy
- Inflammasome and immune disorders
- Urinary Tract Infections Management
- Escherichia coli research studies
- Bacterial Infections and Vaccines
- COVID-19 Clinical Research Studies
Universidad Autónoma de Nuevo León
2016-2025
Hospital Universitario Dr José Eleuterio Gonzalez
2016-2025
University of California, San Diego
2025
University of Monterrey
2021-2022
Hospital Civil de Guadalajara
2019
<b><i>Background:</i></b> Bacterial species from the ESKAPE group (i.e. <i>Enterococcus faecium</i>, <i>Staphylococcus aureus</i>, <i>Klebsiella pneumoniae</i>,<i> Acinetobacter baumannii</i>, <i>Pseudomonas aeruginosa</i> and <i>Enterobacter </i>species) are frequently resistant to antibiotics. The purpose of this study was monitor incidence pathogens at intensive care unit (ICU) a tertiary...
We aimed to assess the resistance rates of antimicrobial-resistant, in bacterial pathogens epidemiological importance 47 Mexican centers.In this retrospective study, we included a stratified sample centers, covering 20 states. Selected isolates considered as potential causatives disease collected over 6-month period were included. Laboratories employed their usual methods perform microbiological studies. The results deposited into database and analyzed with WHONET 5.6 software.In total...
Chronic kidney disease (CKD) is a progressive loss of renal function in which gut dysbiosis involved. Fecal microbiota transplantation (FMT) may be promising alternative for restoring and treating CKD. This study evaluated the changes CKD progression patients treated with FMT. Patients diabetes and/or hypertension clinical stages 2, 3, 4 this single-center, double-blind, randomized, placebo-controlled trial (NCT04361097) were randomly assigned to receive either FMT or placebo capsules 6...
Abstract Rapid identification and characterisation of drug-resistant bacterial pathogens have an important role in diagnostic antimicrobial stewardship. Response time the diagnosis not only etiological agent but also susceptibility results is utmost importance patient treatment. In this study, matrix-assisted laser desorption ionisation–time flight (MALDI-TOF) mass spectrometry (MS) was used to screen for biomarkers ESCAPE (vancomycin-resistant E nterococcus faecium , methicillin-resistant S...
This report presents phenotypic and genetic data on the prevalence characteristics of extended-spectrum β-lactamases (ESBLs) representative carbapenemases-producing Gram-negative species in Mexico.A total 52 centers participated, 43 hospital-based laboratories 9 external laboratories. The distribution antimicrobial resistance for Escherichia coli, Klebsiella pneumoniae, Enterobacter cloacae complex, Acinetobacter baumannii Pseudomonas aeruginosa selected clinical specimens from January 1 to...
Stenotrophomonas maltophilia is an important multidrug-resistant nosocomial pathogen associated with high mortality. Our aim was to examine antimicrobial susceptibility, biofilm production and clonal relatedness of clinical isolates S. maltophilia. were collected between 2006 2013 from two tertiary care hospitals in Mexico. Antimicrobial susceptibility evaluated by the broth microdilution method. PCR used determine presence β-lactamase genes L1 L2. Biofilm formation assessed crystal violet...
Background Among Coagulase-Negative Staphylococci (CoNS), Staphylococcus hominis represents the third most common organism recoverable from blood of immunocompromised patients. The aim this study was to characterize biofilm formation, antibiotic resistance, define SCCmec (Staphylococcal Chromosomal Cassette mec) type, and genetic relatedness clinical S. isolates. Methodology isolates (n = 21) were screened for formation using crystal violet staining. Methicillin resistance evaluated...
Background: Surveillance of antimicrobial resistance (AMR) requires an international approach with national and local strategies. Our aim was to summarize a retrospective 10-year report antibiotic gram-positive gram-negative bacteria in Mexico. Methods: A total 46 centers from 22 states Mexico participated. Databases AMR January 2009 December 2018 were included for most species. The period divided into five 2-year periods. Results: For Staphylococcus aureus, decrease all specimens observed...
Clostridium difficile NAP1/ribotype 027 is associated with severe disease and high mortality rates. Our aim was to determine the prevalence of among C. isolates in a tertiary care hospital, review main clinical data.We included 106 stool samples from patients. Samples were tested for A&B toxins cultured on CCFA agar. The genes tcdA, tcdB, tcdC, cdtA, cdtB amplified using PCR isolates. tcdA 3'-end deletion analysis, PCR-ribotyping, pulsed-field gel electrophoresis (PFGE) also performed. Stool...
Stenotrophomonas maltophilia is a multidrug-resistant opportunistic pathogen causing an increasing number of nosocomial infections. Our aim was to evaluate the risk factors and mechanisms associated with trimethoprim-sulfamethoxazole (SXT) resistance in S. infections Mexico.Clinical isolates patients' demographic clinical data were collected from February 2007 August 2015 two tertiary-care hospitals Mexico. Antimicrobial susceptibility analysis sul SmeABC SmeDEF efflux pump overexpression...
Abstract Background Tuberculosis diagnosis requires rapid and sensitive diagnostic methods. The aim was to evaluate the performance of Anyplex MTB/NTM Xpert MTB/RIF assays for detection Mycobacterium tuberculosis complex (MTC) in respiratory non-respiratory samples from patients suspected having a third-level hospital Mexico. Methods Samples (n=436) January 2020 December 2023 Monterrey, Mexico underwent paired microbiological (MGIT or Lowenstein-Jensen culture) molecular (Anyplex™ Real-time...
Abstract Cerebral amyloid angiopathy (CAA) is a common feature of Alzheimer’s disease in which amyloid-β (Aβ) deposits cerebral and leptomeningeal vessel walls, predisposing vessels to micro- macro-hemorrhages. The walls contain distinct proteins heparan sulfate (HS), yet how vascular HS jointly associate with Aβ unknown. We conducted the first multi-omics study systematically characterize as well abundance, sulfation level, disaccharide composition leptomeninges from 23 moderate severe CAA...
Background/Objectives: Antibiotic-associated diarrhea (AAD) is a public health problem that develops in the hospital setting. The most common causative agent of AAD Clostridioides difficile infection (CDI), although other non-difficile Clostridia (NDC) might also be present. NDC include members RIC group such as Clostridium ramosum [T. ramosa], innocuum and clostridioforme [E. clostridioformis]. co-colonization CDI patients with has not been fully analyzed. Methods: We compared clinical...
Determining the genetic diversity of M. tuberculosis strains allows identification distinct Mycobacterium genotypes responsible for in different regions. Several studies have reported Mexico, but little information is available from state Jalisco. Therefore, aim this study was to determine clinical isolates Western Mexico. Sixty-eight were tested susceptibility first-line drugs using manual Mycobacteria Growth Indicator Tube method and genotyped spoligotyping IS6110-restriction fragment...
The worldwide dissemination of high-risk carbapenemase-producing Klebsiella pneumoniae clones has become a major threat to healthcare facilities. This study describes the successful containment hospital outbreak caused by NDM-1-producing K. Sequence Type (ST) 307 using active surveillance. began when patient was transferred from local hospital. After 48 hours in our hospital, tracheal aspirate positive for meropenem resistant and pneumoniae. All patients medical intensive care unit (ICU)...
Clostridium [Clostridioides] difficile infection (CDI) is one of the leading causes diarrhea associated with medical care worldwide, and up to 60% patients CDI can develop a recurrent (R-CDI). A multi-species microbiota biofilm model C. was designed evaluate differences in production biofilms, sporulation, susceptibility drugs, expression sporulating (sigH, spo0A), quorum sensing (agrD1, luxS), adhesion-associated (slpA cwp84) pathway genes between selected isolates from R-CDI non-recurrent...
Aim . In this study, we conducted a comparative study to explore the differences in therapeutic efficacy and intestinal microbiome of fecal microbiota transplant (FMT) vs. FMT addition with Lactobacillus (FMT-L) for treatment recurrent Clostridioides difficile infection (R-CDI). Methods We designed double-blinded randomized two-arm pilot multicenter assess impact standard capsules FMT-L enriched 3 species patients R-CDI. A 90-day follow-up 21 was performed, starting at beginning study. From...
We report the successful treatment of a bloodstream infection caused by Klebsiella pneumoniae harbouring NDM-1 using aztreonam-ceftazidime-avibactam in neutropenic patient whom colistin and meropenem therapy had previously failed. A clinical isolate was evaluated to determine presence NDM, TEM, SHV, CTX, CMY, killing kinetics aztreonam (ATM; 4 μg/mL), aztreonam-avibactam (ATM-AVI; 4/4 (2 μg/mL) were tested. ATM-AVI showed vitro activity against NDM-1, whereas allowed re-growth. This supports...