A5089666995- Neonatal Respiratory Health Research
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Medical Imaging and Pathology Studies
- Metabolism, Diabetes, and Cancer
- Mesenchymal stem cell research
- interferon and immune responses
- Extracellular vesicles in disease
- Ubiquitin and proteasome pathways
- Nitric Oxide and Endothelin Effects
- Immune cells in cancer
- Advanced Glycation End Products research
Kangwon National University
2020-2022
Abstract Detailed understanding of the pathogenesis and development effective therapies for pulmonary fibrosis (PF) have been hampered by lack in vitro human models that recapitulate disease pathophysiology. In this study, we generated alveolar organoids (AOs) derived from pluripotent stem cells (hPSCs) use as an PF model drug efficacy evaluation. Stepwise direct differentiation hPSCs into epithelial mimicking developmental cues a temporally controlled manner was used to generate...
Hyperglycemia is a causative factor in the pathogenesis of respiratory diseases, known to induce fibrosis and inflammation lung. However, little attention has been paid genes related hyperglycemic-induced lung alterations stem cell applications for therapeutic use. In this study, our microarray data revealed significantly increased levels junctional adhesion molecule 2 (JAM2) high glucose (HG)-induced transcriptional profile human perivascular cells (hPVCs). The elevated level JAM2...
Diabetes mellitus is a common heterogeneous metabolic disorder, characterized by deposition of extracellular matrix, oxidative stress, and vascular dysfunction, thereby leading to gradual loss function in multiple organs. However, little attention has been paid gene expression changes the lung under hyperglycemic conditions. In this study, we found that diabetes inuced histological streptozotocin-induced diabetic mice. Global profiling revealed set genes are up- down-regulated Among these,...
Respiratory medicine has high barriers to new drug development, with fewer approved treatments and candidate drugs a higher failure rate than other common disease fields. Most of the major identified in preclinical animal studies fail clinical setting because differences between models humans. Therefore, rapid development 3-dimensional (3D) organoid-based that recapitulate human pathological attracted increasing attention personalized medicine. In present study, we generated bronchoalveolar...