A5023900503- Autophagy in Disease and Therapy
- Parkinson's Disease Mechanisms and Treatments
- Calcium signaling and nucleotide metabolism
- Cannabis and Cannabinoid Research
- Alzheimer's disease research and treatments
- Circadian rhythm and melatonin
- Retinoids in leukemia and cellular processes
- Adenosine and Purinergic Signaling
- Metal complexes synthesis and properties
- Protein Kinase Regulation and GTPase Signaling
- Plant tissue culture and regeneration
- Bioactive Natural Diterpenoids Research
- Neuroinflammation and Neurodegeneration Mechanisms
- Transgenic Plants and Applications
- Endoplasmic Reticulum Stress and Disease
- Nerve injury and regeneration
- Genetics, Aging, and Longevity in Model Organisms
- Estrogen and related hormone effects
- Bioactive natural compounds
- Sirtuins and Resveratrol in Medicine
- Genetic Neurodegenerative Diseases
- Ferroptosis and cancer prognosis
- Mangiferin and Mango Extracts
- interferon and immune responses
- Trace Elements in Health
Universidade Federal de São Paulo
2017-2025
Mitochondria-associated ER membranes (MAMs) are formed by close and specific components in the contact sites between endoplasmic reticulum (ER) mitochondria, which participate several cell functions, including lipid metabolism, autophagy, Ca2+ signaling. Particularly, presence of α-synuclein (α-syn) MAMs was previously demonstrated, indicating a physical interaction among some proteins this region potential involvement dysfunctions. alterations associated with neurodegenerative diseases such...
Abstract α‐Synuclein is the major component of neuronal cytoplasmic aggregates called Lewy bodies, main pathological hallmark Parkinson disease. Although neurons are predominant cells expressing α‐synuclein in brain, recent studies have demonstrated that primary astrocytes culture also express and regulate trafficking. Astrocytes a neuroprotective role several detrimental brain conditions; we therefore analyzed effects overexpression wild‐type its A30P A53T mutants on autophagy apoptosis. We...
Huntington's disease (HD) is a progressive neurodegenerative characterized by mutations in the huntingtin gene (mHtt), causing an unstable repeat of CAG trinucleotide, leading to abnormal long repeats polyglutamine (poly-Q) N-terminal region huntingtin, which form conformations and aggregates. Alterations Ca2+ signaling are involved HD models accumulation mutated interferes with homeostasis. Lysosomes intracellular storages that participate endocytic lysosomal degradation processes,...
Aging is a multifactorial process associated with functional deficits, and the brain more prone to developing chronic degenerative diseases such as Parkinson's disease. Several groups have tried correlate age-related ultrastructural alterations neurodegeneration using in vivo pharmacological models, but due limitations of animal particularly aged animals, results are difficult interpret. In this work, we investigated induced by rotenone, model disease, both young Wistar rats. We assessed...
Regeneration of injured skeletal muscles is affected by fibrosis, which can be improved the administration angiotensin II (AngII) receptor (ATR) blockers in normotensive animals. However, role ATR muscle fibrosis hypertensive organisms has not been investigated yet. The tibialis anterior (TA) spontaneously (SHR) and Wistar rats (WR) were lacerated a lentivector encoding microRNA targeting AngII type 1 (At1) (Lv-mirAT1a) or control (Lv-mirCTL) was injected. TA collected after 30 days to...
The pharmacological modulation of autophagy is considered a promising neuroprotective strategy. While it has been postulated that lithium regulates this cellular process, the age-related effects have not fully elucidated. Here, we evaluated lithium-mediated in young and aged striatum. After determining optimal experimental conditions for inducing loco with carbonate (Li2CO3), measured cell viability, reactive oxygen species (ROS) generation consumption rat brain striatal slices from animals....