A5025485398- Global Maternal and Child Health
- Connective tissue disorders research
- Oral health in cancer treatment
- Management of metastatic bone disease
- Photoacoustic and Ultrasonic Imaging
- Mobile Health and mHealth Applications
- Infrared Thermography in Medicine
- Thermography and Photoacoustic Techniques
- Bone health and treatments
- Organ and Tissue Transplantation Research
- ICT in Developing Communities
- Digital Imaging in Medicine
- Emergency and Acute Care Studies
- Maternal and Perinatal Health Interventions
- Bone and Dental Protein Studies
- Maternal and fetal healthcare
- Healthcare Systems and Reforms
- Heterotopic Ossification and Related Conditions
- Pregnancy-related medical research
- Insect Utilization and Effects
- TGF-β signaling in diseases
- Animal and Plant Science Education
- Effects of Radiation Exposure
- Viral Infections and Outbreaks Research
- Bone fractures and treatments
Spectrum Health
2022-2024
Corewell Health
2024
Michigan State University
2019-2023
University of Michigan
2010-2020
Orthopaedic Research Laboratories
2015-2020
Michigan Medicine
2016-2018
Michigan United
2011-2015
University of South Carolina
2012-2014
C. S. Mott Children's Hospital
2013
Ann Arbor Center for Independent Living
2013
Cyclophilin B (CyPB), encoded by PPIB, is an ER-resident peptidyl-prolyl cis-trans isomerase (PPIase) that functions independently and as a component of the collagen prolyl 3-hydroxylation complex. CyPB proposed to be major PPIase catalyzing rate-limiting step in folding. Mutations PPIB cause recessively inherited osteogenesis imperfecta type IX, moderately severe lethal bone dysplasia. To investigate role folding post-translational modifications, we generated Ppib−/− mice recapitulate OI...
We discovered a new spontaneous mutant allele of Npr2 named peewee (pwe) that exhibits severe disproportionate dwarfism and female infertility. The pwe phenotype is caused by four base-pair deletion in exon 3 generates premature stop codon at 313 (L313X). Npr2pwe/pwe mouse model for the human skeletal dysplasia acromesomelic dysplasia, Maroteaux type (AMDM). conducted thorough analysis reproductive tract report primary cause infertility oocyte meiotic resumption, while pituitary uterus...
Osteoporosis is a progressive bone disease that characterized by decrease in mass and the deterioration microarchitecture.This study investigates feasibility of characterizing microstructure analyzing frequency spectrum photoacoustic (PA) signal from bone.Modeling numerical simulation PA were performed on trabecular simulations CT scans with different thicknesses.The resulting quasi-linear spectra fittted linear regression, which spectral parameter slope was quantified.The based two models...
As communities' fears of Ebola virus disease (EVD) in West Africa exacerbate and their trust healthcare providers diminishes, EVD has the potential to reverse recent progress made promoting facility-based delivery. Using retrospective data from a study focused on maternal newborn health, this analysis examined influence use maternity care Bong Country, Liberia, which shares boarder with Sierra Leone - near epicenter outbreak. case series design, logbooks were collected at 12 sites one...
ABSTRACT Type III collagen (Col3) has been proposed to play a key role in tissue repair based upon its temporospatial expression during the healing process of many tissues, including bone. Given our previous finding that Col3 regulates quality cutaneous repair, as well recent data supporting regulating osteoblast differentiation and trabecular bone quantity, we hypothesized mice with diminished would exhibit altered long‐bone fracture healing. To determine young adult wild‐type (Col3+/+)...
The feasibility of an innovative biomedical diagnostic technique, thermal photo-acoustic (TPA) measurement, for non-ionizing and non-invasive assessment bone health is investigated. Unlike conventional PA methods that are mostly focused on the measurement absolute signal intensity, TPA targets change in intensity as a function sample temperature, i.e., temperature-dependent Grueneisen parameter closely relevant to chemical molecular properties sample. Based differentiation results from...
ABSTRACT Heterotopic ossification (HO) is the abnormal formation of bone in soft tissue. Current diagnostics have low sensitivity or specificity to incremental progression mineralization, especially at early time points. Without accurate and reliable diagnosis intervention, HO often results incapacitating conditions limited range motion, nerve entrapment, pain. We hypothesized that non‐invasive near‐infrared (NIR) optical imaging can detect points monitor heterotopic turnover longitudinally....
Increased encounters with the healthcare system at multiple levels have potential to improve maternal and newborn outcomes. The literature is replete evidence on impact of antenatal care postnatal Additionally, maternity waiting homes (MWHs) been identified as a critical link in continuum for health yet there scant data associations among MWH use antenatal/postnatal attendance, family planning immunization rates newborns.A cross-sectional household survey was conducted collect from women who...
Postpartum hemorrhage (PPH) is the leading cause of maternal mortality in Africa and Asia. Despite an UN Millennium Development Goal to reduce rates, no significant effect has resulted date, large part because women these areas give birth rural communities with poor access definitive care. Traditional attendants (TBAs) provide care for delivering mothers; however, they are neither trained nor equipped recognize or manage PPH as a life-threatening emergent condition. The purpose this study...
Background While the medical contributors to maternal mortality are well known, contextual less known and understudied. Liberia has one of highest rates in sub-Saharan Africa, with recent increases deaths rural Bong County. The purpose this study was better classify factors leading up develop a list recommendations prevent future similar deaths. Methods A retrospective mixed method conducted examining 35 County, using verbal autopsy reports from 2019. An interdisciplinary death audit team...
This study indicates a higher rate of facility delivery at clinics with maternity waiting home in rural Zambia.
Objective Descriptions of maternity waiting homes (MWHs) as an intervention to increase facility delivery for women living in remote geographic areas dates back the 1950s, yet there is limited information on scale-up and sustainability MWHs. The objective this study was describe evolutionary MWHs a component health system strengthening efforts document successes, challenges, barriers Liberia. Methods Data were collected from national sample 119 Liberia established between 2010–2018. used...
Introduction: Bimanual uterine compression may provide a reasonable treatment option for controlling or arresting postpartum hemorrhage in areas where access to care and advanced medical interventions are limited. Preliminary evidence suggests that correctly performed bimanual is unsustainable more than few minutes, despite empirical practice recommendations support extended optimal effect. The objective of this study was examine the impact team‐based (pairs) managing from atony. Methods:...
Thrombospondin-2 (TSP2) is a matricellular protein component of the bone extracellular matrix. Long bones adult TSP2-deficient mice have increased endosteal thickness due to expansion osteoblast progenitor cell pool, and these cells display deficits in osteoblastic potential. Here, we investigated effects TSP2 deficiency on whole geometric mechanical properties growing 6-wk-old male female wild-type TSP2-knockout (KO) mice. Microcomputed tomography testing were conducted femora L2 vertebrae...
The authors have previously demonstrated that amifostine prophylaxis mitigates the pernicious effects of radiation in settings fracture repair and distraction osteogenesis. Expanding on these studies, examined biomechanical properties uninjured bone exposed to both amifostine. hypothesize will degrade native bone, further prophylactic preserve levels normal protect against radiation-induced morbidities.Rats were randomized into control, irradiated, pretreatment plus (amifostine-pretreated)...