A5090356141- Occupational and environmental lung diseases
- Nanoplatforms for cancer theranostics
- Pleural and Pulmonary Diseases
- Medical Imaging and Pathology Studies
- Photodynamic Therapy Research Studies
- Cancer Research and Treatments
- Protein Kinase Regulation and GTPase Signaling
- 14-3-3 protein interactions
- Signaling Pathways in Disease
- Cancer Immunotherapy and Biomarkers
- Cardiomyopathy and Myosin Studies
- Cardiac Fibrosis and Remodeling
- Cancer, Hypoxia, and Metabolism
- Angiogenesis and VEGF in Cancer
- Vascular Tumors and Angiosarcomas
- Cardiac electrophysiology and arrhythmias
- Cellular Mechanics and Interactions
- Neuroblastoma Research and Treatments
- Receptor Mechanisms and Signaling
- Cancer-related Molecular Pathways
- Viral Infections and Immunology Research
- Nanoparticle-Based Drug Delivery
- Cell Adhesion Molecules Research
- Gut microbiota and health
- Lipid metabolism and disorders
University of Lausanne
2009-2025
Swiss Cancer Center Léman
2024-2025
University Hospital of Lausanne
2016-2024
Mutations in APC promote colorectal cancer (CRC) progression through uncontrolled WNT signaling. Patients with desmoplastic CRC have a significantly worse prognosis and do not benefit from chemotherapy, but the mechanisms underlying differential responses of APC-mutant CRCs to chemotherapy are well understood. We report that expression transcription factor prospero homeobox 1 (PROX1) was reduced human CRCs. In genetic Apc-mutant mouse models, loss Prox1 promoted growth desmoplastic,...
Abstract Myocardial inflammation following myocardial infarction (MI) is crucial for proper healing, yet, dysregulated may promote adverse ventricular remodeling and heart failure. IL-1 signaling contributes to these processes, as shown by dampened inhibition of IL-1β or the receptor. In contrast, potential role IL-1α in mechanisms has received much less attention. Previously described a myocardial-derived alarmin, also act systemically released inflammatory cytokine. We therefore...
The mitogen-activated protein kinases (MAPKs) pathways are highly organized signaling systems that transduce extracellular signals into a variety of intracellular responses. In this context, it is currently poorly understood how constituting these cascades assembled and activated in response to receptor stimulation generate specific cellular Here, we show AKAP-Lbc, an A-kinase anchoring (AKAP) with intrinsic Rho-specific guanine nucleotide exchange factor activity, critically involved the...
<div>Abstract<p>Pleural mesothelioma is a fatal disease with limited treatment options. Recently, pleural management has improved the development of immune checkpoint inhibitors (ICI). In first-line therapy, dual PD-1 and CTLA-4 blockade enhances tumor control patient survival compared chemotherapy. Unfortunately, only fraction patients responsive to immunotherapy, approaches reshape microenvironment make ICIs more effective are urgently required. this study, we evaluated effect...
<p>Supplementary Figure S5: Impact of HITOC on tumor-infiltrating T cells.</p>
<p>Supplementary Figure S3: Representative flow cytometry histograms.</p>
<p>Supplementary Figure S4: Effect of HITOC on CD4 T cell infiltration in tumors.</p>
<p>Supplementary Figure S1: Evaluation of the impact heat adjunct on cisplatin cytotoxicity.</p>
<p>Supplementary Figure S6: Effect of HITOC on PD-1 and CTLA-4 expression by CD4 T cells.</p>
<p>Supplementary Figure S2: Flow cytometry gating.</p>
Abstract Immune checkpoint inhibitors (ICIs) have significantly improved the outcome of non-small cell lung cancers (NSCLCs). However, cancer response to ICIs occurs in a fraction patients and correlates with presence tumor-infiltrating lymphocytes (TILs). Thus, methods increase TILs within are urgently needed. Previously, murine model malignant pleural mesothelioma, we described mechanism by which low dose photodynamic therapy (L-PDT) enhanced vascular expression E-selectin favored...
AKAP-Lbc is a member of the A-kinase anchoring protein (AKAP) family that has been recently associated with development pathologies, such as cardiac hypertrophy and cancer. We have previously demonstrated that, at molecular level, functions guanine nucleotide exchange factor (GEF) promotes specific activation RhoA. In present study, we identified ubiquitin-like LC3 novel regulatory interacting AKAP-Lbc. Mutagenesis studies revealed LC3, through its NH2-terminal α-helical domain, interacts...
Vascular‐targeted low‐dose photodynamic therapy (L‐PDT) was shown to improve chemotherapy distribution in malignant pleural tumors such as mesothelioma (MPM). However, the mechanisms triggered by L‐PDT on tumor vasculature are still debated. In pericyte and endothelial cell co‐cultures, we show that pericytes exhibit enhanced sensitivity towards compared cells, displaying actin stress fibers cellular contraction via Rho/ROCK kinase signaling myosin light chain focal adhesion phosphorylation...
ObjectiveMalignant pleural mesothelioma is a fatal disease and clinical challenge, as few effective treatment modalities are available. Previous evidence links the gut microbiome to host immunoreactivity tumors. We thus evaluated impact of novel modulator compound (MMC) on microbiota composition, tumor immune microenvironment, cancer control in model malignant mesothelioma.MethodsAge- weight-matched immunocompetent (n = 23) or athymic BALB/c mice 15) were randomly assigned MMC no (control)...
Low-dose photodynamic therapy PDT (photoinduction) can modulate tumor vessels and enhance the uptake of liposomal cisplatin (Lipoplatin®) in pleural malignancies. However, photo-induction conditions must be tightly controlled as overtreatment shuts down enhances normal tissue drug uptake.In a sarcoma adenocarcinoma rat model (n = 12/group), we applied photoinduction (0.0625 mg/kg Visudyne®, 10 J/cm2 ) followed by intravenous Lipoplatin® (5 mg/kg) administration. Tumor IFP were assessed...
Abstract Human pleural mesothelioma is an incurable and chemoresistant cancer. Using a nude mouse xenograft model of human mesothelioma, we show that RAPTA-T, compound undergoing preclinical evaluation, enhances tumor vascular function by decreasing blood vessel tortuosity dilation, while increasing the coverage endothelial cells pericytes perfusion within tumors. This in turn significantly reduces interstitial fluid pressure increases oxygenation tumor. Consequently, RAPTA-T pre-treatment...
Abstract Pleural mesothelioma is a fatal disease with limited treatment options. Recently, pleural management has improved the development of immune checkpoint inhibitors (ICI). In first-line therapy, dual PD-1 and CTLA-4 blockade enhances tumor control patient survival compared chemotherapy. Unfortunately, only fraction patients responsive to immunotherapy, approaches reshape microenvironment make ICIs more effective are urgently required. this study, we evaluated effect hyperthermic...
Malignant pleural mesothelioma (MPM) is a deadly disease with limited treatment options. Approaches to enhance patient immunity against MPM have been tested but shown variable results. Previously, we demonstrated interesting vascular modulating properties of low-dose photodynamic therapy (L-PDT) on MPM. Here, hypothesized that L-PDT modulation could favour immune cell extravasation in and improve tumour control combination checkpoint inhibitors.First, assessed the impact endothelial...