A5057576852- Occupational and environmental lung diseases
- Pleural and Pulmonary Diseases
- Medical Imaging and Pathology Studies
- Cancer Research and Treatments
- Immune cells in cancer
- Cancer Immunotherapy and Biomarkers
- Nanoplatforms for cancer theranostics
- Neuroblastoma Research and Treatments
- Pancreatic and Hepatic Oncology Research
- Single-cell and spatial transcriptomics
- Photoacoustic and Ultrasonic Imaging
- Immune Response and Inflammation
- Photodynamic Therapy Research Studies
- Neuroinflammation and Neurodegeneration Mechanisms
- Glioma Diagnosis and Treatment
Swiss Cancer Center Léman
2024
University of Lausanne
2021-2024
Ludwig Cancer Research
2023
Neutrophils are abundant immune cells in the circulation and frequently infiltrate tumors substantial numbers. However, their precise functions different cancer types remain incompletely understood, including brain microenvironment. We therefore investigated neutrophils tumor tissue of glioma metastasis patients, with matched peripheral blood, herein describe first in-depth analysis neutrophil phenotypes these tissues. Orthogonal profiling strategies humans mice revealed that...
Abstract Immune checkpoint inhibitors (ICIs) have significantly improved the outcome of non-small cell lung cancers (NSCLCs). However, cancer response to ICIs occurs in a fraction patients and correlates with presence tumor-infiltrating lymphocytes (TILs). Thus, methods increase TILs within are urgently needed. Previously, murine model malignant pleural mesothelioma, we described mechanism by which low dose photodynamic therapy (L-PDT) enhanced vascular expression E-selectin favored...
<div>Abstract<p>Pleural mesothelioma is a fatal disease with limited treatment options. Recently, pleural management has improved the development of immune checkpoint inhibitors (ICI). In first-line therapy, dual PD-1 and CTLA-4 blockade enhances tumor control patient survival compared chemotherapy. Unfortunately, only fraction patients responsive to immunotherapy, approaches reshape microenvironment make ICIs more effective are urgently required. this study, we evaluated effect...
<p>Supplementary Figure S5: Impact of HITOC on tumor-infiltrating T cells.</p>
<p>Supplementary Figure S3: Representative flow cytometry histograms.</p>
<p>Supplementary Figure S4: Effect of HITOC on CD4 T cell infiltration in tumors.</p>
<p>Supplementary Figure S1: Evaluation of the impact heat adjunct on cisplatin cytotoxicity.</p>
<p>Supplementary Figure S6: Effect of HITOC on PD-1 and CTLA-4 expression by CD4 T cells.</p>
<p>Supplementary Figure S2: Flow cytometry gating.</p>
ObjectiveMalignant pleural mesothelioma is a fatal disease and clinical challenge, as few effective treatment modalities are available. Previous evidence links the gut microbiome to host immunoreactivity tumors. We thus evaluated impact of novel modulator compound (MMC) on microbiota composition, tumor immune microenvironment, cancer control in model malignant mesothelioma.MethodsAge- weight-matched immunocompetent (n = 23) or athymic BALB/c mice 15) were randomly assigned MMC no (control)...
Abstract Pleural mesothelioma is a fatal disease with limited treatment options. Recently, pleural management has improved the development of immune checkpoint inhibitors (ICI). In first-line therapy, dual PD-1 and CTLA-4 blockade enhances tumor control patient survival compared chemotherapy. Unfortunately, only fraction patients responsive to immunotherapy, approaches reshape microenvironment make ICIs more effective are urgently required. this study, we evaluated effect hyperthermic...
Abstract Introduction: The management of malignant pleural mesothelioma (MPM) remains challenging with poor patient survival. Local therapies such as hyperthermic intrathoracic cisplatin (HITOC) have shown good tumor control in selected patients. HITOC was to increase MPM drug exposure while limiting systemic side effects but alternative mechanisms for are still lacking. Here, we hypothesized that induces an immune response directed against which decreases cancer related mortality. Methods:...