A5035709346- Mathematical Biology Tumor Growth
- Advanced Fiber Laser Technologies
- Photorefractive and Nonlinear Optics
- Nonlinear Photonic Systems
- Orbital Angular Momentum in Optics
- Photonic and Optical Devices
- Glioma Diagnosis and Treatment
- Cancer, Hypoxia, and Metabolism
- Nonlinear Waves and Solitons
- Cancer Genomics and Diagnostics
- Microtubule and mitosis dynamics
- Diabetes Management and Research
- Spectroscopy and Quantum Chemical Studies
- Quantum Information and Cryptography
- Protein Structure and Dynamics
- Evolution and Genetic Dynamics
- Quantum optics and atomic interactions
- Radiomics and Machine Learning in Medical Imaging
- Management of metastatic bone disease
- Hemodynamic Monitoring and Therapy
- Medical Imaging Techniques and Applications
- Single-cell and spatial transcriptomics
- Laser-Matter Interactions and Applications
- Immune cells in cancer
- Cold Atom Physics and Bose-Einstein Condensates
University of Castilla-La Mancha
2015-2024
Universitat de València
2020-2024
Universidad Peruana Cayetano Heredia
2021
Mohammed V University
2020
Universitat Autònoma de Barcelona
2005-2008
Institute for High Energy Physics
2004-2006
Universidad Autónoma de Madrid
2000-2004
Institute of Photonic Sciences
2004
Universitat Politècnica de Catalunya
2004
Institute of Physics of the Slovak Academy of Sciences
2002
Neutrophils are increasingly recognized as key players in the tumor immune response and associated with poor clinical outcomes. Despite recent advances characterizing diversity of neutrophil states cancer, common trajectories mechanisms governing ontogeny relationship between these remain undefined. Here, we demonstrate that immature mature neutrophils enter tumors undergo irreversible epigenetic, transcriptional, proteomic modifications to converge into a distinct, terminally differentiated...
Neutrophils are abundant immune cells in the circulation and frequently infiltrate tumors substantial numbers. However, their precise functions different cancer types remain incompletely understood, including brain microenvironment. We therefore investigated neutrophils tumor tissue of glioma metastasis patients, with matched peripheral blood, herein describe first in-depth analysis neutrophil phenotypes these tissues. Orthogonal profiling strategies humans mice revealed that...
Light beams carrying orbital angular momentum, such as Laguerre-Gaussian beams, give rise to the violation of standard dipolar selection rules during interaction with matter yielding, in general, an exchange momentum larger than hbar per absorbed photon. By means ab initio 3D numerical simulations, we investigate detail a hydrogen atom intense Gaussian and light pulses. We analyze dependence polarization, carrier-envelope phase light, well relative position between vortex. In addition,...
Glioblastoma is a rapidly evolving high-grade astrocytoma that distinguished pathologically from lower grade gliomas by the presence of necrosis and microvascular hyperplasia. Necrotic areas are typically surrounded hypercellular regions known as "pseudopalisades" originated local tumor vessel occlusions induce collective cellular migration events. This leads to formation waves cells actively migrating away central hypoxia. We present mathematical model incorporates interplay among two cell...
Intense laser ionization expands Einstein's photoelectric effect rules giving a wealth of phenomena widely studied over the last decades. In all cases, so far, photons were assumed to carry one unit angular momentum. However it is now clear that can possess extra momentum, orbital momentum (OAM), related their spatial profile. We show complete description photoionization by OAM photons, including new selection involving more than explore theoretically interaction single electron atom located...
Abstract Drug resistance limits the therapeutic efficacy in cancers and leads to tumor recurrence through ill-defined mechanisms. Glioblastoma (GBM) are deadliest brain tumors adults. GBM, at diagnosis or after treatment, resistant temozolomide (TMZ), standard chemotherapy. To better understand acquisition of this resistance, we performed a longitudinal study, using combination mathematical models, RNA sequencing, single cell analyses, functional drug assays human glioma line (U251). After...
Significance Through the use of different in silico modeling approaches capturing tumor heterogeneity, we postulated that areas high metabolic activity would shift toward periphery as tumors become more aggressive. To confirm hypothesis and provide clinical value for finding, collected 18 F-FDG PET images breast cancers non–small-cell lung cancers, where measured distance from point maximum to centroid, normalizing it by a surrogate volume. The metric, NHOC, showed higher prognostic than...
A quantum-field-theory approach is put forward to generalize the concept of classical spatial light beams carrying orbital angular momentum single-photon level. This quantization framework carried out both in paraxial and nonparaxial regimes. Upon extension optical phase space, closed-form expressions are found for a photon Wigner representation describing transformations on Poincar\'e sphere unitarily related families modes.
Journal Article Some Notes on Time Inconsistency and Rawls' Maximin Criterion Get access Guillermo Calvo Columbia University Search for other works by this author on: Oxford Academic Google Scholar The Review of Economic Studies, Volume 45, Issue 1, February 1978, Pages 97–102, https://doi.org/10.2307/2297087 Published: 01 1978
Abstract Development of drug resistance in cancer has major implications for patients’ outcome. It is related to processes involved the decrease efficacy, which are strongly influenced by intratumor heterogeneity and changes microenvironment. Heterogeneity arises, a large extent, from genetic mutations analogously Darwinian evolution, when selection tumor cells results adaptation microenvironment, but could also emerge as consequence epigenetic driven stochastic events. An important...
We put forward a nonlinear wave model describing the fundamental dynamical features of an aggressive type brain tumors. Our accounts for invasion normal tissue by proliferating and propagating rim active glioma cancer cells in tumor boundary subsequent formation necrotic core. By resorting to numerical simulations, phase space analysis, exact solutions we prove that bright solitary waves develop such systems. Possible implications our as tool extract relevant patient specific parameters...
An exact Wigner representation of optical spatial modes carrying orbital angular momentum is found in closed form by exploiting the underlying SU(2) Lie-group algebra their associated Poincaré sphere. Orthogonality relations and observables these states are obtained within phase space picture. Development geometric phases on mode transformations also elucidated.
Iron oxide nanoparticles (IONPs) are suitable materials for contrast enhancement in magnetic resonance imaging (MRI). Their potential clinical applications range from diagnosis to therapy and follow-up treatments. However, a deeper understanding of the interaction between IONPs, culture media cells is necessary expanding application this technology different types cancer therapies. To achieve new insights these interactions, set IONPs were prepared with same inorganic core five distinct...
This paper focuses on the affective component of a Driver Behavioural Model (DBM), specifically modelling some driver's mental states, such as load and active fatigue, which may affect driving performance. We used Bayesian networks (BNs) to explore dependencies between various relevant variables estimate probability that driver was in particular state based their physiological demographic conditions. Through this approach, our goal is improve understanding behaviour dynamic environments,...
When light is transmitted through optically inhomogeneous and anisotropic media the spatial distribution of can be modified according to its input polarization state. A complete analysis this process, based on paraxial approximation, presented, we show how it exploited produce a spin-controlled change in orbital angular momentum beams propagating patterned space-variant optical axis phase plates. We also unveil new effect: development strong modulation upon variation path
Glioblastoma multiforme (GBM), the most frequent type of primary brain tumour, is a rapidly evolving and spatially heterogeneous high-grade astrocytoma that presents areas necrosis, hypercellularity microvascular hyperplasia. The aberrant vasculature leads to hypoxic results in an increase oxidative stress, selecting for more invasive tumour cell phenotypes. In our study, we assay silico different therapeutic approaches which combine antithrombotics (ATs), antioxidants standard radiotherapy...