A5035698554- Pleural and Pulmonary Diseases
- Lung Cancer Diagnosis and Treatment
- Transplantation: Methods and Outcomes
- Occupational and environmental lung diseases
- Medical Imaging and Pathology Studies
- Organ Transplantation Techniques and Outcomes
- Mechanical Circulatory Support Devices
- Renal Transplantation Outcomes and Treatments
- Cardiac Structural Anomalies and Repair
- Enhanced Recovery After Surgery
- Tracheal and airway disorders
- Cardiac, Anesthesia and Surgical Outcomes
- Myasthenia Gravis and Thymoma
- Cancer Immunotherapy and Biomarkers
- Gastric Cancer Management and Outcomes
- Pulmonary Hypertension Research and Treatments
- Cancer Research and Treatments
- Cancer Diagnosis and Treatment
- Lung Cancer Treatments and Mutations
- Hepatocellular Carcinoma Treatment and Prognosis
- Heart Failure Treatment and Management
- Surgical site infection prevention
- Nutrition and Health in Aging
- Radiomics and Machine Learning in Medical Imaging
- Management of metastatic bone disease
University of Lausanne
2020-2025
University Hospital of Lausanne
2009-2024
University Health Network
2021-2022
Toronto General Hospital
2021-2022
University of Toronto
2021-2022
Thoracic Surgery Foundation
2017
Cold static preservation on ice (~4°C) remains the clinical standard of donor organ preservation. However, mitochondrial injury develops during prolonged storage, which limits extent time that organs can maintain viability. We explored feasibility lung storage at 10°C using a large animal model and investigated mechanisms related to protection. Functional assessments performed ex vivo perfusion demonstrated porcine lungs stored for 36 hours had lower airway pressures, higher compliances,...
Donor organ allocation is dependent on ABO matching, restricting the opportunity for some patients to receive a life-saving transplant. The enzymes FpGalNAc deacetylase and FpGalactosaminidase, used in combination, have been described effectively convert group A (ABO-A) red blood cells (RBCs) O (ABO-O). Here, we study safety preclinical efficacy of using these remove antigen (A-Ag) from human donor lungs ex vivo lung perfusion (EVLP). First, ability A-Ag perfusate solutions was examined five...
Abstract Background Compared to lobectomy by video-assisted thoracic surgery (VATS), segmentectomy VATS has a potential higher risk of postoperative atelectasis and air leakage. We compared complications between these two procedures, analyzed their factors. Methods reviewed the records all patients who underwent anatomical pulmonary resections from January 2014 March 2018 in Swiss university hospitals. All were reported. A logistic regression model was used compare risks for interventions....
Enhanced recovery after surgery (ERAS) programs have been reported to decrease complications and shorten hospital stays lung resections, but their implementation requires time financial investment with dedicated staff. The aim of this study was evaluate the clinical economic outcomes video-assisted thoracoscopic (VATS) anatomical pulmonary resections before an ERAS program.The first 50 consecutive patients undergoing VATS lobectomy or segmentectomy for malignancy program were compared...
This study evaluates the effect of enhanced recovery after surgery (ERAS) pathways on postoperative outcomes non-small cell lung cancer (NSCLC) patients undergoing video-assisted thoracic (VATS) lobectomy.We retrospectively reviewed all consecutive VATS lobectomy for NSCLC between January 2014 and October 2019 assigned them to relevant group ("pre-ERAS" or "ERAS"). Length stay, readmissions complications within 30 days were compared both groups. A propensity score-matched analysis was...
We aimed to evaluate whether computed tomography (CT)-derived preoperative sarcopenia measures were associated with postoperative outcomes and survival after video-assisted thoracoscopic (VATS) anatomical pulmonary resection in patients early-stage non-small cell lung cancer (NSCLC). retrospectively reviewed all consecutive that underwent VATS for NSCLC between 2012 2019. Skeletal muscle mass was measured at L3 vertebral level on CT or PET/CT scans identify sarcopenic according established...
Abstract OBJECTIVES Transient heat stress (HS) application during experimental ex vivo lung perfusion (EVLP) of warm ischaemic (WI) rat lungs produces a range therapeutic benefits. Here, we explored whether different EVLP durations after HS would influence its effects. METHODS In protocol 1, WI were exposed to (41.5°C, 60–90 min EVLP), and was maintained for 3, 4.5 or 6 h (n = 5/group), followed by physiological measurements (compliance, oedema, oxygenation capacity). 2, treated with (HS...
<div>Abstract<p>Pleural mesothelioma is a fatal disease with limited treatment options. Recently, pleural management has improved the development of immune checkpoint inhibitors (ICI). In first-line therapy, dual PD-1 and CTLA-4 blockade enhances tumor control patient survival compared chemotherapy. Unfortunately, only fraction patients responsive to immunotherapy, approaches reshape microenvironment make ICIs more effective are urgently required. this study, we evaluated effect...
<p>Supplementary Figure S5: Impact of HITOC on tumor-infiltrating T cells.</p>
<p>Supplementary Figure S3: Representative flow cytometry histograms.</p>
<p>Supplementary Figure S4: Effect of HITOC on CD4 T cell infiltration in tumors.</p>
<p>Supplementary Figure S1: Evaluation of the impact heat adjunct on cisplatin cytotoxicity.</p>
<p>Supplementary Figure S6: Effect of HITOC on PD-1 and CTLA-4 expression by CD4 T cells.</p>
<p>Supplementary Figure S2: Flow cytometry gating.</p>
Abstract Background Advances in non-small cell lung cancer (NSCLC) management have extended survival rates, contributing to a higher incidence of second primary NSCLC (2-20%). Repeated anatomical pulmonary resection these cases poses significant technical challenges and functional limitations due previous surgery. Aims This study evaluates the feasibility short-term outcomes repeated resections for NSCLC. Methods We retrospectively reviewed all consecutive performed our institution from...