A5065928177- Transplantation: Methods and Outcomes
- Health and Medical Studies
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Psychiatric care and mental health services
- Organ Transplantation Techniques and Outcomes
- Tracheal and airway disorders
- School Health and Nursing Education
- Renal Transplantation Outcomes and Treatments
- Clinical practice guidelines implementation
- Medical and Health Sciences Research
- Medical Practices and Rehabilitation
- Nursing Diagnosis and Documentation
- Congenital Diaphragmatic Hernia Studies
- Pleural and Pulmonary Diseases
- Respiratory viral infections research
- Ethics in medical practice
- Lung Cancer Diagnosis and Treatment
- Hematological disorders and diagnostics
- Social and Demographic Issues in Germany
- Health, Medicine and Society
- Myasthenia Gravis and Thymoma
- Biomedical and Chemical Research
- Trauma Management and Diagnosis
- Mechanical Circulatory Support Devices
- Quality and Safety in Healthcare
University of Tokyo Hospital
2024-2025
The University of Tokyo
2013-2024
University Health Network
2020-2024
University of Toronto
2020-2024
Waseda University
2024
Toronto General Hospital
2020-2023
Toronto General Hospital Research Institute
2021-2022
Toranomon Hospital
2018-2020
Chigasaki Rehabilitation College
2019
Kyoto University
2005-2018
BackgroundCold static preservation (CSP) at higher temperatures (10°C) has been recently shown as an optimal strategy up to 24-36h of preservation. Here, we hypothesized that alternating 10°C storage with cycles normothermic ex vivo lung perfusion (EVLP) would provide conditions for cellular "recharge", allowing multi-day preservation.MethodsDonor lungs from male Yorkshire pigs were preserved using CSP two 4h EVLP. After a total 3 days preservation, left transplant was performed followed by...
The impact of red cell distribution width (RDW) on outcomes in elderly patients after surgery for non-small lung cancer (NSCLC) is not fully understood.
The number of octogenarian lung cancer patients undergoing radical surgery has been increasing recently. However, knowledge regarding the risk factors for postoperative complications and reliable predictive long-term survival is limited. This study aimed to investigate complications, prognostic factors, in older than 80 years.Lung aged years or who underwent were retrospectively studied; a multi-institutional analysis was conducted from January 1998 December 2015. Preoperative clinical data,...
Abstract Background The epidemiology, microbiology, and clinical course of nontuberculous mycobacterial (NTM) infection among lung transplant recipients vary considerably by geographic location. Their data is still scarce. Methods This single-center retrospective study was conducted at one the major centers in Japan. Medical records microbiological test results all who underwent transplants between 2015 to 2023 were reviewed through December 31, 2023. Per institutional protocol, tracheal...
The Glasgow Prognostic Score (GPS), which is calculated with C-reactive protein (CRP) and albumin (Alb) values, a prognostic indicator for various types of cancers. However, its role in lung cancer still remains unclear, optimal cut-off values are controversial. Here, we evaluated the significance GPS adjusted (a-GPS) using our institution's patients undergoing resection primary cancer.We analysed 1043 who underwent between 1998 2012. overall survival (OS) probabilities subgroups were...
Although cytomegalovirus (CMV) viremia/DNAemia has been associated with reduced survival after lung transplantation, its association chronic allograft dysfunction (CLAD) and phenotypes is unclear. We hypothesized that, in a modern era of CMV prophylaxis, DNAemia would still remain death, but also represent risk factor for CLAD specifically restrictive syndrome (RAS)/mixed phenotype. This was single-center retrospective cohort study all consecutive adult, first, bilateral-/single-lung...
Abstract OBJECTIVES Dual-lumen cannulas for veno-venous (VV) extracorporeal membrane oxygenation (ECMO) support are typically inserted in the right internal jugular vein (RIJV); however, some scenarios can make this venous route inaccessible. This multicentre case series aims to evaluate if single-site cannulation using an alternative access is safe and feasible patients with inaccessible RIJV. METHODS We performed a multi-institutional retrospective analysis including high-volume ECMO...
Acral lentiginous melanoma (ALM) occurring on the sole of foot is most common type malignant in Asians, African and North American Blacks, but relatively infrequent Caucasians. According to literature ALM thought less likely arise a precursor naevus any or be associated with dysplastic naevi elsewhere skin. We present five cases (two invasive three situ cases) arising association pre-existing Asians All patients were female, aged 35-66 years (mean = 47.8). Clinically, all tumours...
Baseline lung allograft dysfunction (BLAD) refers to a condition in which transplant recipient does not achieve normal pulmonary function (i.e., forced expiratory volume 1 s or vital capacity of <80% predicted values). Although BLAD is reportedly associated with poor prognosis, the has been examined Japanese patients.
We examined the effects of tranilast on tumor angiogenesis, growth and metastasis in mouse Lewis lung carcinoma C57BL system. Tranilast significantly reduced dense capillary network induced by cancer cells a dorsal air sac angiogenesis model. Intraperitoneal administration at 200 mg/kg/day size to about 63% that control suppressed pulmonary spontaneous Immunohistochemistry revealed vascularity increased apoptosis vivo. potentiated inhibition cyclophosphamide,...
Fibrin glue effectively controls air leakage in lung surgery; however, allogenic fibrin cannot eliminate the risks of infection and allergy despite current sterilization methods. Autologous (AFG) could be a good alternative, but is not commonly used worldwide because its limited availability lack evidence. Herein, we report clinical outcomes AFG thoracic surgery.We retrospectively analyzed patients who underwent lobectomies or segmentectomies between November 2016 September 2017 our...
Effective treatment of respiratory infections continues to be a major challenge. In high doses (≥160 ppm), inhaled Nitric Oxide (iNO) has been shown act as broad-spectrum antimicrobial agent, including its efficacy in vitro for coronavirus family. However, the safety prolonged vivo implementation high-dose iNO therapy not studied. Herein we aim explore feasibility and delivering continuous over an extended period time using animal model. Yorkshire pigs were randomized one following two...