A5022730793- Immune Cell Function and Interaction
- T-cell and B-cell Immunology
- Immunotherapy and Immune Responses
- COVID-19 Clinical Research Studies
- SARS-CoV-2 and COVID-19 Research
- Renal Transplantation Outcomes and Treatments
- Cancer Genomics and Diagnostics
- COVID-19 and healthcare impacts
- Long-Term Effects of COVID-19
- Organ Transplantation Techniques and Outcomes
- Hepatitis C virus research
- Saffron Plant Research Studies
- Hematopoietic Stem Cell Transplantation
- Organ Donation and Transplantation
- Reproductive System and Pregnancy
- Mast cells and histamine
- Immunodeficiency and Autoimmune Disorders
- Systemic Lupus Erythematosus Research
- Cancer Cells and Metastasis
- Liver Disease Diagnosis and Treatment
- Immune Response and Inflammation
- Liver Disease and Transplantation
- Hepatitis B Virus Studies
- Cell Adhesion Molecules Research
- Pregnancy and Medication Impact
Hospital General Universitario de Albacete
2003-2025
Complejo Hospitalario Universitario de Albacete
2018-2025
Hospital Universitario Virgen de la Arrixaca
1993-2006
Hospital General Universitario Santa María del Rosell
1996
ABSTRACT HLA‐DRB1*08:130 shows a Leucine at position 64 not described previously.
ABSTRACT Genomic sequence of HLA‐B*14:01:01:12, ‐B*15:01:01:67, ‐B*35:01:01:90, ‐B*35:03:01:38, ‐B*35:31:01:02, ‐B*41:01:01:09, ‐B*44:02:01:85 alleles.
Genomic sequence of HLA-A*01:01:01:119, -A*23:01:01:34, -A*23:01:01:35, -A*29:02:01:40, -A*33:01:01:17 and -A*33:01:01:19 alleles.
We used an experimental model in the rat to examine effects of long-term treatment with crocin, a glycosylated carotenoid from stigmas saffron crocus, on colon cancer. BD-IX rats were divided into four groups: Groups G1 and G2, designated "cancer groups," study crocin progression cancer, G3 G4, "toxicity metabolic processes parenchyma. DHD/K12-PROb cells injected subcutaneously chest Group G2 animals. From 1 13 weeks after inoculation, animals G4 received weekly injection (400 mg/kg body wt...
The SARS-CoV-2 infection has widely spread to become the greatest public health challenge date, COVID-19 pandemic. Different fatality rates among countries are probably due non-standardized records being carried out by local authorities. Spanish case-fatality rate is 11.22%, far higher than those reported in Asia or other European countries. A multicentre retrospective study of demographic, clinical, laboratory and immunological features 584 hospitalized patients their outcomes was...
SARS-CoV-2 vaccines are an invaluable resource against COVID-19. Current vaccine shortage makes it necessary to prioritize distribution the most appropriate segments of population.This is a prospective cohort study 63 health care workers (HCWs) from General Hospital. We compared antibody responses two doses BNT162b2 mRNA COVID-19 between HCWs with previous infection (experienced HCWs) and without (naïve HCWs).Seven days after first dose, experienced 126-fold increase in levels (p<0·001)....
Clinical and experimental observations suggest that more than one pathway might be involved in the development of metastases. In present study, we examined presence tumor DNA plasma using an model which cells were modified with a genome-associated tag. We also investigated whether tumor-bearing rats had any effect on cultured healthy animals.Transfected cancer (DHD/K12-PROb stably transfected pCDNA3.1CAT.) injected subcutaneously into chest BD-IX rats. Animals divided ten groups according to...
HLA‐DQA1*05:115 shows an alanine at position 59 not described previously.
Despite the efficacy and safety of SARS-CoV-2 vaccines, inflammatory and/or thrombotic episodes have been reported. Since impact COVID-19 vaccines on endothelium remains uncertain, our objective was to assess endothelial activation status before 90 days after third dose BNT162b2 mRNA vaccine. A prospective longitudinal study conducted at University General Hospital Albacete, involving 38 healthy health-care workers. Serum levels markers (endocan sVCAM-1) spike S1-specific IgG antibodies were...
ABSTRACT Genomic sequence of HLA‐B*40:06:01:20 and HLA‐DRB1*09:61N alleles detected in a Spanish individual.
In 2015, the Spanish National Transplant Organization developed a prioritization system (Program for Access to Transplantation Highly Sensitized Patients [PATHI]) increase transplant options patients with calculated panel-reactive antibodies (cPRAs) ≥98%, based on virtual crossmatch. We describe experience implementation of PATHI and assess its efficacy.
Characterization of HLA‐B*40:01:02:61 , ‐B*48:01:01:14 and ‐C*01:02:01:69 alleles in Spanish individuals.
Characterization of HLA‐DQB1*02:02:01:18 , ‐DQB1*02:02:01:19 ‐DQB1*03:02:01:20 and ‐DQB1*05:03:01:10 alleles in Spanish individuals.
Characterisation of HLA-DQA1*01:02:01:30, HLA-DQA1*01:03:01:14, HLA-DQA1*03:03:01:20, HLA-DQA1*04:01:01:13, HLA-DQA1*05:05:01:40 alleles in Spanish individuals.
Background After exposure to SARS-CoV-2 and/or vaccination there is an increase in serum antibody titers followed by a non-linear waning. Our aim was find out if this waning of would fit mathematical model. Methods We analyzed anti-RBD (receptor binding domain) IgG and the breakthrough infections over ten-month period following second dose mRNA BNT162b2 (Pfizer-BioNtech.) vaccine, cohort 54 health-care workers (HCWs) who were either never infected with (naïve, nHCW group, n=27) or previously...
Four novel HLA-DQA1 alleles, -DQA1*01:01:02:04, -DQA1*01:04:01:05, -DQA1*03:03:01:19 and -DQA1*05:01:01:08, characterized in Spanish individuals.
ABSTRACT Genomic sequence of HLA‐DPA1*01:03:01:81, ‐DPA1*01:03:01:89, ‐DPA1*01:03:01:90, ‐DPA1*01:03:01:91, ‐DPA1*01:03:01:93 and ‐DPA1*01:03:01:94 alleles in Spanish individuals.
The benefits of the "no-touch" isolation technique usually performed to prevent circulation tumor cells are not evident. aim this study was determine whether conventional surgical procedures for treatment colon cancer could provoke detected by a genetic technology.Sixteen patients undergoing resection colorectal and two with irresectable tumors were studied. No patient showed liver or lung metastasis. With specific primers carcinoembryonic antigen, we used reverse transcriptase-polymerase...