A5060347257- Cancer Immunotherapy and Biomarkers
- Nitric Oxide and Endothelin Effects
- Immunotherapy and Immune Responses
- CAR-T cell therapy research
- Hepatocellular Carcinoma Treatment and Prognosis
- Eicosanoids and Hypertension Pharmacology
- Viral-associated cancers and disorders
- Heme Oxygenase-1 and Carbon Monoxide
- Photodynamic Therapy Research Studies
- Gastric Cancer Management and Outcomes
- Berberine and alkaloids research
- Cardiac Ischemia and Reperfusion
- Lymphoma Diagnosis and Treatment
- Esophageal Cancer Research and Treatment
- Phagocytosis and Immune Regulation
- Vascular Tumors and Angiosarcomas
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Electrochemical Analysis and Applications
- Morinda citrifolia extract uses
- Parathyroid Disorders and Treatments
- Cancer Genomics and Diagnostics
- Laser Applications in Dentistry and Medicine
- Tea Polyphenols and Effects
- Apelin-related biomedical research
- Phytochemicals and Antioxidant Activities
Sichuan University
2021-2025
Sichuan Cancer Hospital
2023-2025
Guangxi Medical University
2025
The First People's Hospital of Shunde
2018-2024
Southern Medical University
2018-2024
West China Hospital of Sichuan University
2021-2023
Heilongjiang Provincial Hospital
2015-2022
Weatherford College
2022
Creative Commons
2022
Zhangzhou Municipal Hospital of Fujian Province
2022
The specific breast milk-derived metabolites that mediate host-microbiota interactions and contribute to the onset of atopic dermatitis (AD) remain unknown require further investigation.
Abstract: Atherosclerosis (AS) is the most vital cardiovascular disease, which poses a great threat to human health. Macrophages play an important role in progression of AS. Photodynamic therapy (PDT) has emerged as useful therapeutic modality not only treatment cancer but also The purpose this study was determine molecular mechanisms underlying activity PDT, using mesoporous-silica-coated upconversion fluorescent nanoparticles encapsulating chlorin e6 (UCNPs-Ce6) induction apoptosis THP-1...
The aim of this retrospective study was to probe into clinicopathological features and prognosis early-onset gastric cancer (EOGC) patients aged ≤ 45 years old.This selected 154 young old 158 elderly > 50 admitted West China Hospital Sichuan University in 2009-2019 as the research object. These were further divided two groups according whether tumor can be resected radically. following parameters analyzed: age, gender, helicobacter pylori (HP) infection status, Her-2 pathological type stage,...
Background/Aims: Pseudohypericin (P-HY) and its congener hypericin are the major hydroxylated phenanthroperylenediones present in Hypericum species. Our previous study indicated that was able to function as a sonosensitizer. The potential use of P-HY sonosensitizer for sonodynamic therapy (SDT) requires further exploration. Thus, this aimed investigate effects P-HY-SDT on THP-1 macrophages. Methods: macrophages were incubated with P-HY, cell viability measured using CCK-8 assay. Fluorescence...
Summary 1. The contractile effects of tea polyphenols (TP) and its four principle catechins, namely (–)‐epicatechin (EC), (–)‐epicatechin‐3‐gallate (ECG), (–)‐epigallocatechin (EGC) (–)‐epigallocatechin‐3‐gallate (EGCG), on rat aorta contractility were investigated using the isometric tension recording technique. 2. At concentrations 5–100 mg/L, TP evoked phasic contraction in a concentration‐dependent but endothelium‐independent manner. Of catechins tested, EGCG EGC (3–300 µmol/L), not EC...
Objectives: To evaluate the effect of intense pulsed light (IPL) on Trichophyton rubrum and investigate its mechanism action. Methods: The viability fungi treated with IPL alone combined an NADPH oxidase inhibitor (DPI) pretreatment was determined by MTT assays. reactive oxygen species (ROS) were quantified a DCFH-DA fluorescent probe. Malondialdehyde (MDA) content superoxide dismutase (SOD) glutathione peroxidase (GSH-Px) activities commercial kits. transcription Nox gene using quantitative...
At present, renal injury caused by sepsis seriously endangers the health of patients. Our paper proposed to study protective effects meloxicam (Mel) in sepsis-induced acute kidney (SAKI) and underlying mechanisms.The vitro vivo models SAKI were established using lipopolysaccharide (LPS). Mel was injected intraperitoneally at 60 mg/kg into male C57BL/6 mice 4 hours before LPS injection (10 mg/kg). The HK-2 cells treated with (1 μg/mL) (40 μM). function pathological changes as well...
Background: Vessel perforation during stent mechanical thrombectomy (MT) is a rare and disastrous complication. A routine rescue strategy includes balloon occlusion for tamponade, procedure suspension, lowering or normalizing blood pressure. However, this complication still associated with poor outcome high mortality. Objective: We present our experience intra-arterial injection of thrombin in the treatment vessel secondary to microcatheter/microwire perforation, which prevents further...
Immune-related myocarditis is a severe and even life-threatening immune-related adverse event (irAE) which may also be underestimated due to the challenge in diagnosis. The inherent difference between individuals with immune-associated has received little attention. Our study aimed identify baseline characteristics could contribute distinguishing mild from ICI myocarditis. A retrospective analysis was conducted March 2019 June 2020 West China Hospital, 18 patients were studied. Patients...
Background: There was controversy about ondansetron can reduce the incidence of spinal-induced hypotension and decrease consumption vasopressor in cesarean delivery with spinal anesthesia. We hypothesized that different timing administration may contribute to controversy. Therefore, we aimed determine effect on dose requirement preventing phenylephrine via comparing ED 50 prophylactic phenylephrine. Methods: Seventy-five parturients were finally enrolled this prospective, randomized,...
BACKGROUND:Multiple sclerosis (MS) is an autoimmune disease causing multifocal demyelination and axonal injuries in the central nervous system (CNS). Toll-interleukin-1 receptor (TIR)-domain containing adaptor protein-inducing interferon beta (TRIF) important protein for Toll-like receptors (TLRs) can modulate immune response via regulating cytokine secretion. This study investigated potential function of TRIF MS mice small interference RNA (siRNA). MATERIAL AND METHODS:Isolated mouse...
Primary splenic cancers represent a small number of cancer cases and studies on its clinicopathological features outcomes are limited. Splenic lymphomas primary angiosarcoma (PSA) the 2 most common histological types cancers. This population-based study aimed to investigate clinical characteristics survival patients with or PSA.Patients diagnosed PSA between 2000 2015 were identified from Surveillance Epidemiology End Results database National Cancer Institutes. Overall (OS) cancer-specific...
Immune check inhibitors (ICIs) have moderate response rates (~20%–30%) in some malignancies clinically, and, when used combination with other immunotherapeutic strategies such as DNA tumor vaccines, there is evidence to suggest that they could optimize the efficacy of cancer treatment. In this study, we validated intramuscular injection plasmid (pDNA) encoding OVA combined pDNA α-PD-1 (abbreviated following treatment groups) may enhance therapeutic by means situ gene delivery and enhanced...
Abstract Background Epstein–Barr virus (EBV)‐associated gastric lymphoepithelioma‐like carcinoma (EBVaGLELC) represents a small number of cancer (GC), and research on tumor microenvironment (TME) treatment strategy are still lacking. Aims Here, we aim to elucidate the immune features this rare disease further help develop more effective options. Materials & Methods A retrospective analysis was conducted between 2019 2022 in West China Hospital reveal immunological characteristics...
Most gastric cancer and gastroesophageal junction carcinoma (GEJ) patients are already in the advanced stage at time of diagnosis.Thus, probability radical gastrectomy is low, surgical treatment alone has a poor prognosis due to high recurrence rate.In order reduce distant metastasis after surgery, there have been many attempts made improve perioperative localized cancer, but no uniform criteria exist.Over recent years, immunotherapy revolutionized treatment, immune checkpoint inhibitors...
The preparation of a sensitive amperometric immunosensor for periostin was achieved.The synthesis golg nanoprobe carried out through depositing the gold nanoparticles in situ on silica nanophere functionalized by polydopamine, which followed to label signal antibodies.The method covalent immobilization, antibodies were captured glassy carbon electrode, employed immunosensor.The cyclic voltammetry (CV) investigate performance decorated electrode at different modification stages.Furthermore,...
Immunotherapy, in the shape of immune checkpoint inhibitors (ICIs), has completely changed treatment cancer. However, increasing expense and frequency immune-related side effects, which are frequently associated with combination antibody therapies Fc fragment antibody, have limited patient's ability to benefit from these treatments. Herein, we presented therapeutic effects plasmid-encoded PD-1 CTLA-4 scFvs (single-chain variable fragment) for melanoma