A5050471258- Advanced biosensing and bioanalysis techniques
- RNA modifications and cancer
- Cancer Immunotherapy and Biomarkers
- Cancer-related molecular mechanisms research
- Immunotherapy and Immune Responses
- Monoclonal and Polyclonal Antibodies Research
- Lung Cancer Research Studies
- CAR-T cell therapy research
- Innovative Microfluidic and Catalytic Techniques Innovation
- Microfluidic and Capillary Electrophoresis Applications
- Advanced Nanomaterials in Catalysis
- RNA Research and Splicing
- Biosensors and Analytical Detection
- Lung Cancer Treatments and Mutations
- Cancer Genomics and Diagnostics
- interferon and immune responses
- Systemic Lupus Erythematosus Research
- Plant Diversity and Evolution
- Immune Cell Function and Interaction
- Neuroendocrine Tumor Research Advances
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Radioactive element chemistry and processing
- Brain Metastases and Treatment
- Chemical Synthesis and Characterization
- Immune Response and Inflammation
Southwest Medical University
2025
Sichuan University
2017-2024
Beijing University of Chemical Technology
2024
First Affiliated Hospital of Guangzhou Medical University
2024
State Key Laboratory of Respiratory Disease
2024
Guangzhou Medical University
2024
China General Nuclear Power Corporation (China)
2024
Xiamen University
2023-2024
Sichuan Cancer Hospital
2024
West China Hospital of Sichuan University
2020-2023
<h3>Importance</h3> Although the incidence and prevalence of gastroenteropancreatic neuroendocrine tumors (GEP-NETs) have been thought to increased during past decades, updated epidemiologic survival data are lacking. <h3>Objectives</h3> To conduct an analysis largest cohort patients with GEP-NETs using latest establish a novel nomogram predict probability individual GEP-NETs. <h3>Design, Setting, Participants</h3> In this study, 43 751 diagnosed from January 1, 1975, December 31, 2015, were...
Resistance to temozolomide (TMZ), the standard chemotherapy agent for glioblastoma (GBM), poses a major clinical challenge GBM prognosis. Understanding mechanisms of TMZ resistance can help identify novel drug targets and more effective therapies. Recent studies suggest that bioenergetic alterations cancer cells play important roles in resistance. In our study, altered metabolism was observed using metabolic PCR array. We found stearoyl-coenzyme A desaturase 1 (SCD1), key rate-limiting...
As the main challenge of dental healthcare, oral infectious diseases are highly associated with colonization pathogenic microbes. However, current antibacterial treatments in field stomatology still lack a facile, safe, and universal approach. Herein, we report controllable synthesis copper aluminum-layered double hydroxides (CuAl-LDHs) high Fenton-like catalytic activity, which can be utilized treatment negligible side effects. Our strategy efficiently avoid unwanted doping other divalent...
Abstract With the rapid emergence of antibiotic‐resistant pathogens, nanomaterial‐assisted catalytic sterilization has been well developed to combat pathogenic bacteria by elevating level reactive oxygen species including hydroxyl radical (·OH). Although promising, ultra‐short lifetime and limited diffusion distance ·OH severely limit their practical antibacterial usage. Herein, rational design preparation novel virus‐like copper silicate hollow spheres (CSHSs) are reported, as applications...
Abstract Endosomal single-stranded RNA-sensing Toll-like receptor-7/8 (TLR7/8) plays a pivotal role in inflammation and immune responses autoimmune diseases. However, the mechanisms underlying initiation of TLR7/8-mediated signaling remain to be fully elucidated. Here, we demonstrate that miR-574-5p is aberrantly upregulated tissues lupus prone mice plasma patients, with its expression levels correlating disease activity. binds activates human hTLR8 or murine ortholog mTlr7 elicit series...
There is increasing evidence for the contribution of synuclein alpha (SNCA) to etiology neurological disorders, such as Parkinson’s disease (PD). However, little known about detailed role SNCA in human cancers, especially lung cancers. Here, we evaluated effects on occurrence and prognosis adenocarcinoma (ADC). Comprehensive bioinformatics analyses data obtained from Oncomine platform, protein atlas (HPA) project cancer cell line encyclopedia (CCLE) demonstrated that expression was...
Cytokines play important roles in the immune system and have been regarded as biomarkers. While single cytokine is not specific accurate enough to meet strict diagnosis practice, this work, we constructed a multiplexed detection method for cytokines based on dual bar-code strategy single-molecule counting. Taking interferon-γ (IFN-γ) tumor necrosis factor-α (TNF-α) model analytes, first, magnetic nanobead was functionalized with second antibody primary strands, forming nanoprobe. Then,...
Background The discovery of checkpoint inhibitors towards cytotoxic T-lymphocyte protein 4 (CTLA-4) and programmed cell death 1 (PD-1) has been revolutionary for the treatment cancers. These therapies have only offered an average 20%–30% response rates across tumor spectrum combination agonists tumor-necrosis superfamily members, such as 4-1BB CD40, shown potent efficacy in preclinical studies; however, these exhibited high degrees toxicity with limited human trials. In this study, we...
Radiotherapy is a powerful tool in the treatment of cancer that has advantage preserving normal tissues. However, tumor radioresistance currently remains major impediment to effective RT. Thus, exploring radiation sensitizers urgently needed. In this study, we have shown diosmetin, aglycone lavonoid glycoside from olive leaves, citrus fruits and some medicinal herbs, promising effect on radiotherapy sensitization. our results, DIO could induce G1 phase arrest thus enhance radiosensitivity...
In this work, to evaluate the new circle microchannel device for removal of Cu2+ from water, various parameters on mass transfer effect and extraction efficiency were investigated by employing bis(2-ethylhexyl) phosphate (D2EHPA) as an extractant kerosene a solvent. The mechanism water D2EHPA(R2H2) is follows: + 2.1(R2H2)(o) ⇔ (CuR2·2.2RH)(o) 2H(o)+. contact time diameter found have great volumetric coefficient (KLa). However, temperature, initial pH solution, D2EHPA volume fraction system...