A5016830915- Kidney Stones and Urolithiasis Treatments
- Pediatric Urology and Nephrology Studies
- Renal cell carcinoma treatment
- Bladder and Urothelial Cancer Treatments
- Prostate Cancer Diagnosis and Treatment
- Renal and Vascular Pathologies
- Systemic Lupus Erythematosus Research
- Renal and related cancers
- Osteoarthritis Treatment and Mechanisms
- Epigenetics and DNA Methylation
- interferon and immune responses
- Vascular Malformations and Hemangiomas
- Immune Response and Inflammation
- Prostate Cancer Treatment and Research
- Urologic and reproductive health conditions
- Ureteral procedures and complications
- Organ Transplantation Techniques and Outcomes
- Immune Cell Function and Interaction
- Cancer Immunotherapy and Biomarkers
- Organ Donation and Transplantation
- Vascular anomalies and interventions
- Cancer, Hypoxia, and Metabolism
- Biomedical Research and Pathophysiology
- Pharmacological Effects of Medicinal Plants
- Urinary and Genital Oncology Studies
Nanjing Medical University
2021-2024
Suzhou Municipal Hospital
2023-2024
Linyi People's Hospital
2008-2024
Xiamen University
2020-2024
First Affiliated Hospital of Chinese PLA General Hospital
2016-2017
Southern Medical University
2005-2008
Nanfang Hospital
2008
To study whether miR-21 targets and inhibits tumor suppressor gene PTEN can promote prostate cancer cell proliferation invasion.Prostate lines PC-3 were cultured divided into negative control group (NC group), group, pcDNA3.1 miR-21+pcDNA3.1 miR-21+PTEN that transfected with different miR plasmid, respectively. After 12 h 24 of transfection, the viability invasive number determined; after Bcl-2, Survivin, MMP2, MMP9, PTEN, PI3K, AKT expression in cells determined.After OD value significantly...
Abstract Endosomal single-stranded RNA-sensing Toll-like receptor-7/8 (TLR7/8) plays a pivotal role in inflammation and immune responses autoimmune diseases. However, the mechanisms underlying initiation of TLR7/8-mediated signaling remain to be fully elucidated. Here, we demonstrate that miR-574-5p is aberrantly upregulated tissues lupus prone mice plasma patients, with its expression levels correlating disease activity. binds activates human hTLR8 or murine ortholog mTlr7 elicit series...
The mTOR inhibitor everolimus has been approved as a sequential or second-line therapy for renal cell carcinoma (RCC). However, the development of drug resistance limits its clinical applications. This study aims to address challenge and provide new insights into treatment advanced RCC. Here, cytotoxicity DNA methyltransferase 1 (DNMT1) SGI-1027 in inducing vacuolation methuosis is discovered demonstrated first time. Additionally, exerts synergistic effects with everolimus, their combination...
To study the inhibitory effect of matrine on bladder cancer cell growth and invasion in vitro through PI3K/AKT signaling pathway.Human T24 lines were cultured treated with different doses (0.25 mg/mL, 0.5 mg/mL 1.0 mg/mL) as well 20 μmol/L PI3K inhibitor LY294002 for 24 h, proliferation activity, number invasive cells expression p-PI3K, p-AKT, genes determined.Different could decrease viability value, MMP2 MMP9, increase p16, p21 p27 dose-dependent manner; LY29002 group significantly higher...
(1) Background: The study aimed to construct nomograms improve the detection rates of prostate cancer (PCa) and clinically significant (CSPCa) in Asian population. (2) Methods: This multicenter prospective included a group 293 patients from three hospitals. Univariable multivariable logistic regression analysis was performed identify potential risk factors nomograms. Discrimination, calibration, clinical utility were used assess performance nomogram. web-based dynamic subsequently built...
Increasing numbers of extrapleural solitary fibrous tumours (SFTs), including the prostate SFT, have been reported over last 10-years. Prostate SFT is relatively uncommon, with <20 cases in literature worldwide. In present study, a case, which was initially misdiagnosed as benign prostatic hyperplasia, presented. The patient subjected to three surgeries (cystoscopy and per urethra lithocystotomy, transurethral resection nerve-sparing retropubic radical prostatectomy) prior diagnosis. It...
Objective.The aim of this study was to report the authors' experience with percutaneous intrarenal marsupialization symptomatic peripelvic renal cysts. Material and methods. Thirty-one patients (16 male 15 female, a mean age 49 years) cyst associated chronic flank or lumbar pain urinary infection were selected for 2 μm laser in centre from January 2005 December 2010. Cyst size ranged 4.5 10.5 (mean 6.0) cm. The cysts punctured by technique guided ultrasonography, 20.8 F nephroscope...
To improve the lower immune intensity of DNA vaccines, we developed a vaccine based on prostate cancer-specific antigen (PSA), which has been suggested as potential target for cancer therapy, and enhanced potency using interleukin-12 (IL-12) an intramolecular adjuvant. A series plasmids encoding human PSA, IL-12, their conjugates was constructed injected into female mice intramuscularly, followed by electric pulse. The humoral cellular responses after immunization were detected ELISA...
Patients with urothelial carcinoma (UC) of the bladder have a high risk death in China. However, lack comprehensive molecular profiling Chinese Han population hinders development targeted therapies for cancer. In our present study, we collected fresh tumors from low-grade (T1, N0, M0, G1) non-muscle invasive cancer (NMIBC) patients (n = 16) and high-grade (T2-4, Gx) muscle-invasive (MIBC) their paired normal tissues, subjected total genomic DNAs to next-generation sequencing (NGS) 94...
Abstract Purpose The retroperitoneal robotic assisted partial nephrectomy (RAPN) is suitable for tumors locating on the posterior side of kidney. However, hilar tumor poses an additional surgical challenge due to special location and poor exposure. We developed a novel kidney ventrally rotation technique overcome this difficulty during RAPN evaluated its efficacy in retrospective case-control comparative study. Methods From March 2016 April 2019, total 39 patients with renal underwent RAPN....
Osteoarthritis (OA) is a chronic joint disease with increasing prevalence. Chondrocytes (CHs) are highly differentiated end-stage cells secretory phenotype that keeps the extracellular matrix (ECM) balanced and cartilage environment stable. dedifferentiation causes breakdown, accounting for one of key pathogenesis osteoarthritis. Recently, activation transient receptor potential ankyrin 1 (TRPA1) was claimed to be risk factor in osteoarthritis by causing inflammation degradation. However,...
A horseshoe kidney is a congenital malformation commonly associated with complications such as hydronephrosis, renal calculi, and infections of the pelvis. Renal cell carcinoma extremely rare in kidney; once it occurs, however, intractable because vascular abnormalities. This especially true laparoscopic nephron-sparing surgery, even for tumors <4 cm diameter. We herein report case involving an asymptomatic 65-year-old man incidental finding 4-cm solid mass near isthmus on B-mode...
Perivascular epithelioid cell tumor (PEComa) is a rare mesenchymal with unique histological and immunohistochemical characteristics. Malignant renal carcinoma even rarer its biological behavior still not clear. We report here case of malignant PEComa in male patient. The first symptom the patient was intermittent hematuria. Ultrasound computed tomography scan showed solid mass left kidney. Fibrosarcoma initially diagnosed after radical resection tumor. Six years later, had recurrence...
Background: ShuoTong ureteroscopy (Sotn-ureteroscopy, ST-URS), a new lithotripsy operation method developed on the basis of ureteroscopy, is widely used to treat ureteral stones in China. Its composition includes rigid access sheath, standard mirror, and perfusion aspirator (ST-APM). Here, we compared efficacy safety ST-URS flexible ureteroscope (F-URS) holmium laser treatment unilateral upper calculi. Methods: Retrospective analysis was conducted clinical data 280 patients who met inclusion...
Abstract Endosomal single-stranded RNA-sensing Toll-like receptor-7/8 (TLR7/8) plays a pivotal role in inflammation and immune responses autoimmune diseases. However, the mechanisms underlying initiation of TLR7/8-mediated signaling remain to be fully elucidated. Here, we demonstrate that miR-574-5p is aberrantly upregulated tissues lupus prone mice plasma patients, with its expression levels correlating disease activity. binds activates human hTLR8 or murine ortholog mTlr7 elicit series...
<title>Abstract</title> Purpose We conducted an assessment to investigate the impact of prostate volume on recurrence patients with non-muscle invasive bladder cancer (NMIBC). Subsequently, we developed and validated nomograms accurately evaluate in NMIBC patients. Additionally, examined potential improvement predictive capability achieved by introducing as a variable model. Methods retrospective analysis, enrolling 555 eligible from seven independent medical institutions across China. first...
Osteoarthritis (OA) and rheumatoid arthritis (RA) are often difficult to distinguish in the early stage of disease. The purpose this study was explore similarities differences between two diseases through Mendelian randomization (MR) transcriptome analysis.
Abstract Osteoarthritis (OA) is a frequent chronic illness in orthopedics that poses major hazard to patient health. In situ cell therapy emerging as therapeutic option, but its efficacy influenced by both the inflammatory milieu and amount of stem cells, limiting use. this study, we designed novel injectable porous microsphere (PM) based on microfluidic technology can support mesenchymal cells (MSCs) combining polylactic–glycolic acid copolymer, kartogenin, polydopamine, stromal...