A5019248071- Coal Properties and Utilization
- Ferroptosis and cancer prognosis
- Cancer, Hypoxia, and Metabolism
- Neonatal Respiratory Health Research
- Immune cells in cancer
- Geological and Geochemical Analysis
- Virus-based gene therapy research
- Metabolism and Genetic Disorders
- Animal Virus Infections Studies
- Mitochondrial Function and Pathology
- Cystic Fibrosis Research Advances
- interferon and immune responses
- Renal cell carcinoma treatment
- Fire dynamics and safety research
- earthquake and tectonic studies
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Hydrocarbon exploration and reservoir analysis
- Viral Infections and Immunology Research
- Cancer, Lipids, and Metabolism
- RNA regulation and disease
- Viral gastroenteritis research and epidemiology
- High-pressure geophysics and materials
- Immune Cell Function and Interaction
- Fire Detection and Safety Systems
- Geochemistry and Geologic Mapping
Zhongshan Hospital
2017-2025
Fudan University
2017-2025
Shanghai Medical College of Fudan University
2020-2025
Chengdu University of Traditional Chinese Medicine
2025
Baoshan College
2025
Fifth Affiliated Hospital of Sun Yat-sen University
2025
Materials Science & Engineering
2024
UNSW Sydney
2023-2024
Kunming University of Science and Technology
2024
China Geological Survey
2023-2024
During the 2020 Spring Festival in China, outbreak of a novel coronavirus, named COVID-19 by WHO, brought on worldwide panic. According to clinical data infected patients, radiologic evidence lung edema is common and deserves attention. Lung manifestation acute injury (ALI) may progress hypoxemia potentially respiratory distress syndrome (ARDS). Patients diagnosed with ARDS have poorer prognosis higher mortality. Although no effective treatment formally approved for infection, support...
Abstract Background Hypercholesterolemia is found in patients with chronic lung inflammation, during which airway epithelial cells play important roles maintenance of inflammatory responses to pathogens. The present study aims at molecular mechanisms by cholesterol changes sensitivity response smoking. Methods Human bronchial (HBEs) were stimulated cigarette smoke extract (CSE) and mice exposed CS/lipopolysaccharide (LPS) as models vitro vivo. Severe COPD healthy volunteers also enrolled the...
Background:SERPINE1, a serine protease inhibitor involved in the regulation of plasminogen activation system, was recently identified as cancer-related gene. However, its clinical significance and potential mechanisms pan-cancer remain obscure. Methods: In multi-omics data from public datasets, including The Cancer Genome Atlas (TCGA) Genotype-Tissue Expression (GTEx), online web tools were used to analyze expression SERPINE1 different cancers correlation with prognosis, genetic alteration,...
Sunitinib resistance is, nowadays, the major challenge for advanced renal cell carcinoma patients. Illuminating potential mechanisms and exploring effective strategies to overcome sunitinib are highly desired. We constructed a reliable gene signature which may function as biomarkers prediction of sensitivity clinical prognosis. The expression profiles were obtained from Cancer Genome Atlas database. By performing GEO2R analysis, numerous differentially expressed genes (DEGs) found be...
Abstract Metabolic abnormalities represent one of the pathological features chronic obstructive pulmonary disease (COPD). Glutamic pyruvate transaminase 2 (GPT2) is involved in glutamate metabolism and lipid synthesis pathways, whilst exact roles GPT2 occurrence development COPD remains uncertain. This study aims at investigating how associated genes modulate smoking‐induced airway epithelial damage by reprogramming synthesis. The circulating or human metabolomic lipidomic profiles patients...
Abstract The changes associated with the cutting roof and release pressure mining method in three zones that are susceptible to spontaneous combustion goaf “Y” type ventilation system were studied. For investigated underground coal mine working face, its of have a “U” for traditional method. These systems monitored using beam tube method, evolution characteristics was analysed. monitoring data showed when system, scattered tropical zone converts into oxidation heating after 68.5 m goaf,...
In the last 20 years, accumulating evidence indicates that gut microbiota contribute to development, maturation, and regulation of host immune system mediate anti-pathogen defenses. Lactobacillus casei ( L.casei ) is a normal flora gastrointestinal tract in mammals and, as great mucosal delivery vehicle, has wide use bioengineering. However, diarrhea prevention role commensal intestinal interfered by recombinant (r newborn piglets not well understood. our study, orally fed with r surface...
Acute lung injury/acute respiratory distress syndrome (ALI/ARDS) are life-threatening condition in critically ill patients. Resveratrol (Res), a natural polyphenol, has therapeutic effect animal model with ALI; however, whether Res attenuates ALI through modulation of macrophage phenotypes the remains unknown. We this study treated LPS-induced murine 30 mg/kg and observed significantly reduced severity Res-treated mice 48 hours after treatment. Neutrophil infiltrates were reduced,...
Parent's nutrition knowledge, attitudes, and dietary practices (KAP) play imperative roles in preventing malnutrition for themselves their children. Our study aimed to determine the status contributing factors of KAP among parents children adolescents. A total 1746 (mean age 39.67 ± 5.38 years, females accounting 69.82%) primary junior high school students Weifang, China, completed a self-reported questionnaire August 2021. An analysis Pearson product-moment correlation was conducted...
Kidney renal clear cell carcinoma (KIRC), a prevalent primary malignant tumor within the urinary system, is characterized by significant heterogeneity. It has been shown that ion channels are important targets for anti-tumor therapy. In this study, we screened 70 selected KIRC related homeostasis genes with differential expression. We established diagnostic and prognostic models 15 (PDK4, JPH4, ATP1A3, CCL7, CYP27B1, ABCB6, TNFSF11, MCHR1, TNNI3, ANGPTL3, Ednrb, SAA1, Chrna9, TMPRSS6, CCL14)...
Autophagy related genes (ATGs) play essential roles in maintaining cellular functions, although biological and pathological alterations of ATG phenotypes remain poorly understood. To address this knowledge gap, we utilized the single-cell sequencing technology to elucidate transcriptomic atlas ATGs lung diseases, with a focus on epithelium lymphocytes. This study conducted comprehensive investigation into RNA profiles tissues obtained from healthy subjects patients different diseases through...
Bcl-2 associated athanogene-5 (BAG5) represents a unique BAG cochaperone family member, regulating chaperone activity. We first demonstrated significant differences in Bag5 expression by RNA seq analysis of teratozoospermia and healthy male sperm samples, but the genetic molecular mechanisms governing this process remain elusive. further found that BAG5 has highest human mouse testes. is elevated late stage pachytene spermatocytes spermatids. Targeted inactivation mice induces massive...