A5102971571- Carcinogens and Genotoxicity Assessment
- DNA Repair Mechanisms
- Inflammasome and immune disorders
- Air Quality and Health Impacts
- RNA modifications and cancer
- Curcumin's Biomedical Applications
- Neuroinflammation and Neurodegeneration Mechanisms
- MicroRNA in disease regulation
- Drug Transport and Resistance Mechanisms
- Cancer-related molecular mechanisms research
- Neuroscience and Neuropharmacology Research
- Barrier Structure and Function Studies
- Heme Oxygenase-1 and Carbon Monoxide
- Trace Elements in Health
- Aluminum toxicity and tolerance in plants and animals
- Science, Research, and Medicine
- Selenium in Biological Systems
- Health, Environment, Cognitive Aging
- Nuclear Receptors and Signaling
- Effects and risks of endocrine disrupting chemicals
- Fungal Plant Pathogen Control
- Alzheimer's disease research and treatments
- Heavy Metal Exposure and Toxicity
- Chromium effects and bioremediation
- Synthesis of Organic Compounds
China Medical University
2016-2025
State Council of the People's Republic of China
2017-2018
Aluminum is everywhere in nature and a recognized neurotoxicant closely associated with various neurodegenerative diseases. Neuroinflammation occurs the early stage of diseases, but underlying mechanism by which aluminum induces neuroinflammation remains unclear.A 3-month subchronic exposure mouse model was established drinking water containing chloride (AlCl3). Microglia BV2 cells hippocampal neuron HT22 were treated AlCl3 vitro. BBG YC-1 used as intervention agents.Aluminum could activate...
Aluminum is an environmental toxicant whose long-term exposure closely associated with nervous system impairment. This study mainly investigated neurological impairment induced by subchronic aluminum via activating NLRP3-medicated pyroptosis pathway. In vivo, Kunming mice were exposed to AlCl3 (30.3 mg/kg, 101 mg/kg and 303 mg/kg) drinking water for 3 months, administered Rsv (100 gavage 1 month. Cognitive was assessed Morris maze test, pathological injury detected H&E staining. BBB...
Lanthanum (La) exposure can lead to learning and memory disorder in animals; however, the underlying mechanism of La induced neurotoxicity is still unknown.
Abstract Single nucleotide polymorphisms (SNPs) in 3′UTR of key DNA repair enzyme genes are associated with inter‐individual differences capacity (DRC) and susceptibility to a variety human malignancies such as lung cancer. In this study, seven candidate SNPs DRC‐related including ERCC1 (rs3212986, rs2336219, rs735482), OGG1 (rs1052133), MLH3 (rs108621), CD3EAP (rs1007616), PPP1R13L (rs6966) were analyzed 300 cancer patients controls from the northeast China. Furthermore, we introduced...
Background Benzo[a]pyrene(B[a]P), and its ultimate metabolite Benzo[a]pyrene 7,8-diol 9,10-epoxide (BPDE), are classic DNA damaging carcinogens. damage caused by BPDE is normally repaired Nucleotide Excision Repair (NER), of which ERCC1 ERCC2/XPD exert an indispensable role. Genetic variations in ERCC2 have been related to repair efficiency. In this study we used lymphocytes from healthy individuals show that polymorphisms directly associated with decreased Methods (rs3212986 rs11615)...
Abstract Colorectal cancer ( CRC ), as a malignant tumor of lower digestive tract, has been found to have an increasing morbidity and mortality in China. It was particularly important find some earlier biomarkers predict the risk prognosis. In this study, several polymorphisms on 3′ UTR three DNA repair genes including MLH 3 rs10862, ERCC 1 rs3212986, rs735482, rs2336219, OGG rs1052133 were chosen by bioinformatics exploration, then, case–control study 200 cases controls performed....
Lanthanum is a rare earth element which can have adverse effects on the central nervous system (CNS). However, mechanisms of these are not fully understood. The activated microglia plays an important role in pathogenesis neurodegenerative diseases and thus could be involved mediating toxic lanthanum CNS. Nuclear factor-kappa B (NF-κB) critical nuclear factor regulates expression inflammatory mediators microglia. This study investigated chloride (LaCl3) NF-κB signaling pathway explored...
Lanthanum (La) can accumulate in the brain and impair learning memory.
Aluminum is mainly exposed to the general population through food and water, absorbed into systemic circulation intestine, which in turn damages intestinal barrier.The mice model of subchronic exposure aluminum chloride (AlCl3 ) was established via oral. Tail suspension test used detect depressive behavior. H&E staining performed assess pathological injury. Intestinal permeability estimated by exogenous Evans blue content. The level inflammatory cytokines tight junction protein were assessed...
Numerous genes are arranged in complex overlapping and interlaced patterns, such arrangements potentially contribute to the regulation of gene expression. Previous studies have demonstrated that a region chromosome 19q13.2-3 encompassing excision repair cross-complementation group 1 (ERCC1), CD3e molecule associated protein (CD3EAP) phosphatase regulatory subunit 13 like (PPP1R13L) was found be with risk prognosis non-small cell lung cancer (NSCLC). The present study confirmed hypothesis...
Evidence suggested that abiotic airborne exposures may be associated with changes in body composition. However, more evidence is needed to identify key pollutants linked adverse health effects and their underlying biomolecular mechanisms, particularly sensitive older adults.
Abstract Rare earth elements (REEs) have caused bioaccumulation and adverse health effects attributed to extensive application. The penetrability of REEs across the blood–brain barrier (BBB) contributes their neurotoxicity process, but potential mechanisms affecting BBB integrity are still obscure. present study was designed investigate lanthanum on adheren junctions actin cytoskeleton in vitro using bEnd.3 cells. After chloride (LaCl3, 0.125, 0.25 0.5 mM) treatment, cytotoxicity against...
Objectives Individual variations in the capacity of DNA repair machinery to relieve benzene-induced damage may be key developing chronic benzene poisoning (CBP), an increasingly prevalent occupational disease China. ERCC1 (Excision cross complementation group 1) is located on chromosome 19q13.2–3 and participates crucial steps Nucleotide Excision Repair (NER); moreover, we determined that one its polymorphisms, rs11615, a biomarker for CBP susceptibility our previous report. Our aim further...
Abstract Lead sulfide nanoparticles (PbS NPs) are semiconductor materials that have been widely applied to light-emitting diodes (LEDs), biological fluorescent probes, infrared detection, solar receivers, ion-selective electrodes, and ion-sensitive materials. However, the effects of PbS NPs on central nervous system still unclear. Thus, this study aimed determine, using rats, mechanism action NPs, exposure which results in persistent alterations function. The Morris water maze test showed...
Abstract ERCC1 is a gene for repairing DNA damage whose function related to carcinogenic‐induced tumorigenesis and the effectiveness of platinum therapies. Circular RNAs (circRNAs) are products posttranscriptional regulation with pleiotropic effects on pathogenesis lung cancer. We aim identify that specific circRNAs derived from can regulate key biological processes involved in development performed bioinformatics analysis, vitro experiments, analyzed clinical samples, determine features...
Ulcerative colitis (UC) is associated with gut microbiota dysbiosis. Although alterations in faecal bacteriome and virome have been reported, little known of the composition function mucosa UC. This first study that aims to delineate configuration mucosal human health We performed ultra-deep metagenomic sequencing virus-like particle preparations bacterial 16S rRNA on rectal tissues from 167 Chinese subjects (63 UC, 48 controls Hong Kong; 20 Beijing). assessed UC correlated patient...