A5101445585- Autophagy in Disease and Therapy
- Neuroscience and Neuropharmacology Research
- Alzheimer's disease research and treatments
- Mitochondrial Function and Pathology
- Histone Deacetylase Inhibitors Research
- Memory and Neural Mechanisms
- Acute Myeloid Leukemia Research
- Parkinson's Disease Mechanisms and Treatments
- Retinoids in leukemia and cellular processes
- Neurological Disease Mechanisms and Treatments
- Silicon Carbide Semiconductor Technologies
- Coal Properties and Utilization
- Immune Cell Function and Interaction
- Estrogen and related hormone effects
- Cytomegalovirus and herpesvirus research
- Chronic Lymphocytic Leukemia Research
- Coal and Its By-products
- Plant biochemistry and biosynthesis
- Cancer-related gene regulation
- Acute Lymphoblastic Leukemia research
- Nuclear Receptors and Signaling
- Thermochemical Biomass Conversion Processes
- NF-κB Signaling Pathways
- RNA Interference and Gene Delivery
- Adenosine and Purinergic Signaling
China Medical University
2017-2021
Xuzhou Medical College
2018-2021
State Council of the People's Republic of China
2017-2018
Ningbo University
2017
Icahn School of Medicine at Mount Sinai
2017
Harbin Medical University
2009-2013
Second Military Medical University
2013
Abstract Purpose Anti‐CD19 chimeric antigen receptor T (CAR‐T) cell therapy has demonstrated remarkable efficacy for refractory and relapsed diffuse large B lymphoma (R/R DLBCL). However, this failed in nearly 25% patients mainly due to loss. The authors performed a phase Ⅱ trial by coadministration of anti‐CD19 anti‐CD20 CAR‐T cells treatment R/R DLBCL evaluated its toxicity. Methods Totally 21 with were enrolled study. conditioned fludarabine cyclophosphamide before the infusion cells....
BACKGROUND We investigated the influence of Resolvin D1 (RvD1) on inflammatory response in PC12 cells (a cell model Parkinson disease, PD). MATERIAL AND METHODS 4 mmol/L 1-methyl-4-phenylpyridinium ion (Mpp+) was used for an vitro PD model. 3-(4,5-dimethyl-2-thiazolyl)-2, 5-diphenyl-2-H-tetrazolium bromide (MTT) assay to explore viability. Western blot (WB) experiments were identify nuclear factor-κB (NF-κB), phosphorylated extracellular signal-regulated kinase (p-ERK)/p-Jun N-terminal...
Lanthanum (La) can cause central nervous system damage in rats and lead to learning memory impairment, but the relevant mechanisms have not been fully elucidated.
Lanthanum (La) exposure can lead to learning and memory disorder in animals; however, the underlying mechanism of La induced neurotoxicity is still unknown.
Lanthanum (La) is a kind of rare earth element (REE) widely found in nature. La has neurotoxicity and can impair learning memory, but the underlying mechanism still not completely clear. The mitochondrial calcium uniporter (MCU) complex cause uptake cytoplasmic ([Ca2+]c) into mitochondria thereby resist [Ca2+]c overload. However, abnormal increase matrix ([Ca2+]m) also disturb fission-fusion balance, then induce excessive mitophagy, disrupt quality control (MQC). It unclear whether interfere...
Galanin (Gal), a bioactive neuropeptide, is widely distributed throughout the central nervous system and has diverse modulatory effects. To understand effect of this training‐stimulatory peptide on insulin sensitivity, its antagonist M35 was injected into cerebral ventricle in type 2 diabetic rats. A treadmill running rats used to stimulate circulating Gal secretion mRNA expression. The results showed that significantly decreased glucose infusion rates euglycemic–hyperinsulinemic clamp tests...
The fusion gene AML1-ETO initially dysregulates various cell cycle molecules in t(8;21) acute myeloid leukemia. Aurora kinases have shown great promise treating tumors. However, the efficacy of kinase (AURK) A and B inhibition AML remains unclear. We found that AURK-A inhibitor Alisertib AURK-B Barasertib strongly inhibited growth proliferation cells. quantity size colonies were markedly decreased after a 14-d drug exposure. distribution was blocked at G2/M phase both dose- time-dependent...
Lanthanum (La) can accumulate in the brain and impair learning memory.
Despite advancement in the treatment of diffuse large B-cell lymphoma (DLBCL), many patients tend to relapse or become refractory after initial therapy.Therefore, it is essential identify novel therapeutic targets and drugs, understand molecular pathogenesis mechanism DLBCL, find ways prevent treat relapsed DLBCL.BIX-01294 a small molecule compound that specifically inhibits EHMT2 activity.In this study, we demonstrate BIX-01294 triggered inhibition human DLBCL cell proliferation, lead G1...
Abstract Acute myeloid leukemia (AML) is a heterogeneous disease with unfavorable outcomes. MicroRNAs (miRNAs) are important regulators and prognostic factors involved in AML. To determine the clinical role of miR‐338 AML, total 164 adults de novo AML were collected. These patients classified into chemotherapy group an allogeneic hematopoietic stem cell transplantation (allo‐HSCT) according to treatment, then each was divided two subgroups based on median expression values. We found that...
Cladribine is a purine nucleoside analog used to treat B-cell chronic lymphocytic leukemia and hairy cell leukemia, also functions as an inhibitor of DNA synthesis block the repair damaged DNA.The therapeutic role cladribine against diffuse large lymphoma cells (DLBCL) still undefined.In present study, we demonstrated that inhibited proliferation induced G1 phase arrest in human DLBCL cells.Furthermore, showed apoptosis by decreasing expression c-FLIPL increasing DR4 cleaved form...
Mitochondria play essential roles in eukaryotic cells for glucose metabolism to produce ATP. In Schizosaccharomyces pombe, transcription factor Rst2 can be activated upon deprivation. However, the link between and mitochondrial function remains elusive. Here, we monitored transcriptional activity living using a Renilla luciferase reporter system, found that inhibition of complex III/IV caused reactive oxygen species (ROS) nitric oxide (NO), which turn Rst2. Furthermore, Rst2-GFP was observed...
Sterol regulatory element-binding protein (SREBP), a highly conserved family of membrane-bound transcription factors, is an essential regulator for cellular cholesterol and lipid homeostasis in mammalian cells. Sre1, the homolog SREBP fission yeast Schizosaccharomyces pombe (S. pombe), regulates genes involved transcriptional responses to low sterol as well oxygen. Previous study reported that casein kinase 1 member Hhp2 phosphorylated Sre1 N-terminal factor domain (Sre1N) accelerated Sre1N...
1Icahn School of Medicine at Mount Sinai (Bronx) Medical Training Program, Bronx, NY, 2James J. Peters Veterans Affairs Center, NY
Objective To investigate the effects and its potential mechanism of IKK2 inhibitor LY2409881 on proliferation, cell cycle apoptosis diffuse large B-cell lymphoma (DLBCL) lines. Methods CCK8 assay was used to detect effect proliferation DLBCL lines; Flow cytometry analyze cycle; Western blot mechanism. Results inhibited multiple lines obviously, caused G1 arrest. Furtherly, expression c-FLIP, induced activation DR4 caspase 8. Meanwhile, pro-apoptotic protein BAX anti-apoptotic MCL-1 BCL-2....
To investigate the effects and its potential mechanism of asparaginase on proliferation, cell cycle apoptosis diffuse large B-cell lymphoma (DLBCL) lines.CCK-8 assay was used to detect effect proliferation DLBCL lines. Flow cytometry analyze apoptosis. Western blot mechanism.Asparaginase obviously inhibited multiple lines caused G0/G1 arrest. Furtherly, expression HIF-1α which related poor prognosis patients with DLBCL, up-regulated DR4 caspase 8, reduce c-FLIP. Meanwhile, induced...
Objective In order to obtain enough antibody secreting cells (ASCs,plasma cells) from peripheral blood mononuclear (PBMCs) for the generation of therapeutic human monoclonal antibodies with high affinity,we established method expansion and differentiation B lymphocytes into plasma in vitro activation.Methods PBMCs were isolated three healthy donors influenza vaccination (＞ 10 months) then activated by TLR9 agonistic CpG DNA 2006 cytokines vitro.By flow cytometric analysis,enzyme-linked...
Specialized phagocytes are found in most primitive muhicellular organisms.Their roles homeosta-sis and distinguishing self from non-self evolved with the complexity of organisms their immune sys-tems.The macrophages tissue development equally important.In this review, functions branching morphogenesis, neuronal patterning, angiogenesis bone morphogenesis dis-cussed.In each events mentioned abve, depletion macrophage impairs formation its function.The aim review is to discuss that...