A5008795362- Glycosylation and Glycoproteins Research
- Galectins and Cancer Biology
- RNA modifications and cancer
- Immune Response and Inflammation
- Polyomavirus and related diseases
- Carbohydrate Chemistry and Synthesis
- Cancer-related gene regulation
- Mass Spectrometry Techniques and Applications
- Pancreatic function and diabetes
- Immunotherapy and Immune Responses
- Aquaculture disease management and microbiota
- Metabolism, Diabetes, and Cancer
- Caveolin-1 and cellular processes
- Immune cells in cancer
- Parvovirus B19 Infection Studies
- Immune Cell Function and Interaction
- Crustacean biology and ecology
- Vitamin D Research Studies
- Bone health and osteoporosis research
- Epigenetics and DNA Methylation
- Echinoderm biology and ecology
- Full-Duplex Wireless Communications
- Bacteriophages and microbial interactions
- interferon and immune responses
- Coral and Marine Ecosystems Studies
Centre National de la Recherche Scientifique
2015-2025
Unité de Glycobiologie Structurale et Fonctionnelle
2015-2025
Université de Lille
2015-2025
Centre Hospitalier Universitaire de Lille
2022-2023
(Epi)génomique fonctionnelle métabolique et des dysfonctions dans le diabète de type 2 et des maladies associées
2021-2023
Inserm
2022-2023
Institut Pasteur de Lille
2022-2023
Abstract Background Anemonefish association with sea anemones is a prime example of mutualistic symbiosis. These fish live inside the anemone, benefitting from protection its toxic nematocysts, and in return, protect anemone own predators. How anemonefish manage to avoid their host stings remains unclear. One hypothesis suggests that low levels sialic acids mucus prevent nematocyst discharge. Results This study verified four predictions: (i) has lower acid than non-symbiotic damselfish; (ii)...
The ST6GALNAC5 gene that encodes an α2,6-sialyltransferase involved in the biosynthesis of α-series gangliosides, was previously identified as one genes mediate breast cancer metastasis to brain. We have shown expression MDA-MB-231 cells resulted GD1α ganglioside at cell surface. By using a human blood-brain barrier vitro model recently developed, consisting CD34+ derived endothelial co-cultivated with pericytes, we show decreased interactions between and barrier.
The human acute monocytic leukemia cell line THP-1 is widely used as an in vitro phagocytic model because it exhibits several immune properties similar to native monocyte-derived macrophages. In this study, we investigated the alteration of N- and O-linked glycans well glycosphingolipids, during differentiation, combining mass spectrometry, flow cytometry, quantitative real-time PCR. Mass spectrometry revealed that macrophage differentiation led a marked upregulation expression GM3...
Type 2 diabetes is characterized by chronic hyperglycemia associated with impaired insulin action and secretion. Although the heritability of type high, environment, including blood components, could play a major role in development disease. Amongst environmental effects, epitranscriptomic modifications have been recently shown to affect gene expression glucose homeostasis. The epitranscriptome reversible chemical changes RNA, one most prevalent being m6A methylation RNA. Since pancreatic β...
Although senescent cells can be eliminated by the immune system, they tend to accumulate with age in various tissues. Here we show that evade clearance natural killer (NK) upregulating expression of disialylated ganglioside GD3 at their surface. The increased level on naturally occurs upon aging liver, lung, kidney or bones leads a strong suppression NK-cell-mediated immunosurveillance. In mice, found targeting GD3+ anti-GD3 immunotherapy attenuated development experimentally induced...
α-Series gangliosides define a particular sub-class of glycosphingolipids containing sialic acid α2,6-linked to GalNAc residue that was isolated as minor compound from the brain. The sialyltransferase ST6GalNAc V cloned mouse brain and showed α2,6-sialyltransferase activity almost exclusively for GM1b, form GD1α is considered main enzyme involved in biosynthesis α-series gangliosides. Recently, ST6GALNAC5 identified one genes over-expressed breast cancer cell populations selected their...
BK polyomavirus (BKPyV) is an opportunistic pathogen that uses the b-series gangliosides GD1b and GT1b as entry receptors. Here, we characterize impact of naturally occurring VP1 mutations on ganglioside binding, protein structure, virus tropism. Infectious single mutants E73Q E73A triple mutant A72V-E73Q-E82Q (VQQ) remains sialic acid dependent, all three variants acquire binding to a-series gangliosides, including GD1a. However, VQQ lose ability infect ganglioside-complemented cells, this...
Gangliosides are glycosphingolipids concentrated in glycolipid-enriched membrane microdomains. Mainly restricted to the nervous system healthy adult, complex gangliosides such as GD3 and GD2 have been shown be involved aggressiveness metastasis of neuro-ectoderm derived tumors melanoma neuroblastoma. synthase (GD3S), key enzyme that controls biosynthesis gangliosides, was over-expressed Estrogen Receptor (ER)-negative breast cancer tumors, associated with a decreased overall survival...
Macrophage glycosylation that is essential to the host-immune defense may be modulated by pathogens infection.
Type 2 diabetes (T2D) is a metabolic disorder characterized by loss of pancreatic β-cell function, decreased insulin secretion and increased resistance, that affects more than 537 million people worldwide. Although several treatments are proposed to patients suffering from T2D, long-term control glycemia remains challenge. Therefore, identifying new potential drugs targets positively affect function crucial. Here, we developed an automated approach allow the identification compounds or genes...
Senescent cells accumulate in aging tissues, and their elimination can favor healthy 1-4 . Therefore, therapeutic interventions targeting cellular senescence may be promising strategies for delaying or reversing a vast range of age-related diseases 5 As the immune system are responsible senescent cell 6-11 , possible anti-aging pro-healthspan treatment is specific activation to induce clearance. However, whether this limited by an checkpoint leading tolerance currently unknown. Here, we show...
Abstract Anemonefish association with giant sea anemone is an iconic example of mutualistic symbiosis. Living inside the without triggering firing highly toxic nematocysts present at surface tentacles provides a unique shelter to fish, which in return, by its territorial aggressiveness, protects from predators. The mechanisms fish avoids discharge remain elusive. One hypothesis proposes that absence sialic acids might disable discharge. Here, we verified four predictions about role...
Abstract Type 2 diabetes (T2D) is a metabolic disorder characterized by loss of pancreatic β- cell function, decreased insulin secretion and increased resistance, that affects more than 400 million people worldwide. Although several treatments are proposed to patients suffering from T2D, long-term control glycemia remains challenge. Therefore, identifying new potential drugs targets positively affect β-cell function crucial. Here, we developed an automated approach allow the identification...
Abstract BK Polyomavirus (BKPyV) is an opportunistic pathogen that causes nephropathy in kidney transplant recipients. The BKPyV major capsid protein, VP1, engages gangliosides, lipid-linked sialylated glycans at the cell surface, to gain entry into cells. Here, we characterise influence of VP1 mutations observed patients with persistent post-transplant replication on ganglioside binding, protein structure, and tropism virus two renal lines: 293TT immortalised tubular epithelial (RS)...