A5089653205- Estrogen and related hormone effects
- Retinoids in leukemia and cellular processes
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Coral and Marine Ecosystems Studies
- Aquaculture Nutrition and Growth
- Nuclear Receptors and Signaling
- Physiological and biochemical adaptations
- Neurobiology and Insect Physiology Research
- Developmental Biology and Gene Regulation
- Reproductive biology and impacts on aquatic species
- Animal Genetics and Reproduction
- Genomics and Phylogenetic Studies
- Marine and fisheries research
- dental development and anomalies
- Ichthyology and Marine Biology
- interferon and immune responses
- Fish Biology and Ecology Studies
- Thyroid Disorders and Treatments
- Genomics and Chromatin Dynamics
- Aquaculture disease management and microbiota
- Identification and Quantification in Food
- Chromosomal and Genetic Variations
- Marine Ecology and Invasive Species
- Genetic diversity and population structure
- Receptor Mechanisms and Signaling
Okinawa Institute of Science and Technology Graduate University
2018-2025
Institute of Cellular and Organismic Biology, Academia Sinica
2018-2025
Centre National de la Recherche Scientifique
2014-2025
Japan Lifeline (Japan)
2025
James Cook University
2024
Academia Sinica
2020-2022
Sorbonne Université
2017-2021
Biologie Intégrative des Organismes Marins
2017-2021
Chinese Culture University
2021
Observatoire Océanologique de Banyuls-sur-Mer
2010-2020
Plant-parasitic nematodes are major agricultural pests worldwide and novel approaches to control them sorely needed. We report the draft genome sequence of root-knot nematode Meloidogyne incognita, a biotrophic parasite many crops, including tomato, cotton coffee. Most assembled this asexually reproducing nematode, totaling 86 Mb, exists in pairs homologous but divergent segments. This suggests that ancient allelic regions M. incognita evolving toward effective haploidy, permitting new...
From a database containing the published nuclear hormone receptor (NR) sequences I constructed an alignment of C, D and E domains these molecules. Using this alignment, have performed tree reconstruction using both distance matrix parsimony analysis. The robustness each branch was estimated bootstrap resampling methods. trees by two methods gave congruent topologies. analyses defined six NR subfamilies: (i) large one clustering thyroid receptors (TRs), retinoic acid (RARs), peroxisome...
Cephalochordates, urochordates, and vertebrates evolved from a common ancestor over 520 million years ago. To improve our understanding of chordate evolution the origin vertebrates, we intensively searched for particular genes, gene families, conserved noncoding elements in sequenced genome cephalochordate Branchiostoma floridae, commonly called amphioxus or lancelets. Special attention was given to homeobox opsin genes involved neural crest development, nuclear receptor encoding components...
The nuclear receptor (NR) superfamily comprises, in addition to ligand-activated transcription factors, members for which no ligand has been identified date. We demonstrate that orphan receptors are randomly distributed the evolutionary tree and there is relationship between position of a given liganded chemical nature its ligand. NRs specific metazoans, as revealed by screen NR-related sequences early- non-metazoan organisms. analysis NR gene duplication pattern during evolution metazoans...
There are two estrogen receptor (ER) subtypes in fish, ERα and ERβ, increasing evidence that the ERβ subtype has more than one form. However, there is little information on characteristics functional significance of these ERs adults during development. Here, we report cloning characterization three ER forms, zfERα, zfERβ1, zfERβ2, zebrafish. The percentages identity between receptors suggest existence distinct genes. Each cDNA encoded a protein specifically bound estradiol with dissociation...
Vertebrates have greatly elaborated the basic chordate body plan and evolved highly distinctive genomes that been sculpted by two whole-genome duplications. Here we sequence genome of Mediterranean amphioxus (Branchiostoma lanceolatum) characterize DNA methylation, chromatin accessibility, histone modifications transcriptomes across multiple developmental stages adult tissues to investigate evolution regulation genome. Comparisons with vertebrates identify an intermediate stage in...
Thyroid hormones (TH) are central hormonal regulators, orchestrating gene expression and complex biological processes vital for growth reproduction in variable environments by triggering specific developmental response to external cues. TH serve distinct roles different species: inducing metamorphosis amphibians or teleost fishes, governing metabolic mammals, acting as effectors of seasonality. These multifaceted raise questions about the underlying mechanisms action. Recent evidence...
Bilaterian animals are notably characterized by complex endocrine systems. The receptors for many steroids, retinoids, and other hormones belong to the superfamily of nuclear receptors, which transcription factors regulating aspects development homeostasis. Despite a diversity regulatory mechanisms physiological roles, share common protein organization. To obtain broad picture bilaterian hormone receptor evolution, we have complete set genes from nine animal genome sequences analyzed it in...
The HMG box Is a novel type of DNA-blndlng domain found in diverse group proteins. superfamily comprises a.o. the High Mobility Group proteins HMG1 and HMG2, nucleolar transcription factor UBF, lymphoid factors TCF-1 LEF-1, fungal mating-type genes mat-Mc MATA1, mammalian sex-determining gene SRY. dates back to at least 1,000 million years ago, as Its members appear animals, plants yeast. Alignment all known boxes defined an unusually loose consensus sequence. We constructed phylogenetlc...
Fibrates are widely used hypolipidemic drugs which activate the nuclear peroxisome proliferator-activated receptor (PPAR) alpha and thereby alter transcription of genes controlling lipoprotein metabolism. influence plasma high density its major protein, apolipoprotein (apo) A-I, in an opposite manner man (increase) versus rodents (decrease). In present study we studied molecular mechanisms this species-specific regulation apoA-I expression by fibrates. primary rat human hepatocytes...
Using RT-PCR with degenerated primers followed by screening of a rainbow trout (Oncorhynchus mykiss) intestinal cDNA library, we have isolated from the new corticosteroid receptor which shows high sequence homology other glucocorticoid receptors (GRs), but is clearly different previous GR (named rtGR1). Phylogenetic analysis these two sequences and GRs known in mammals, amphibians fishes indicate that duplication probably common to most teleost fish. The open reading frame this rtGR2)...
The presence of additional hox clusters in the zebrafish has led to hypothesis that there was a whole genome duplication at origin modern fish. To investigate generality this assumption, we analyzed all available actinopterygian fish gene families, and sequenced nuclear receptors from diverse teleost timing duplications systematically determined by phylogenetic analysis. More genes are indeed found than mouse. This abundance is shared major groups euteleost fish, but not eels. Phylogenetic...
The IUPHAR database (IUPHAR-DB) integrates peerreviewed pharmacological, chemical, genetic, functional and anatomical information on the 354 nonsensory G protein-coupled receptors (GPCRs), 71 ligand-gated ion channel subunits 141 voltagegated-like encoded by human, rat mouse genomes.These genes represent targets of approximately one-third currently approved drugs are a major focus drug discovery development programs in pharmaceutical industry.IUPHAR-DB provides comprehensive description...