A5102877989- Protein Degradation and Inhibitors
- Ubiquitin and proteasome pathways
- Multiple Myeloma Research and Treatments
- Microbial Community Ecology and Physiology
- Peptidase Inhibition and Analysis
- Cell Image Analysis Techniques
- RNA Research and Splicing
- Advanced Breast Cancer Therapies
- Biochemical Analysis and Sensing Techniques
- Plant biochemistry and biosynthesis
- Computational Drug Discovery Methods
- Plant Reproductive Biology
- Neuropeptides and Animal Physiology
- 14-3-3 protein interactions
- Viral Infectious Diseases and Gene Expression in Insects
- Biopolymer Synthesis and Applications
- Biochemical and Structural Characterization
- Phagocytosis and Immune Regulation
- Advanced Fluorescence Microscopy Techniques
- Cell death mechanisms and regulation
- Erythrocyte Function and Pathophysiology
- Neuroblastoma Research and Treatments
Fox Chase Cancer Center
2019-2023
University of Kansas
2015-2023
Amgen (United States)
2022
High Throughput Biology (United States)
2015
Purdue University West Lafayette
2009-2011
Proteolysis-targeting chimaeras (PROTACs) are molecules that combine a target-binding warhead with an E3 ligase-recruiting moiety; by drawing the target protein into ternary complex ligase, PROTACs induce degradation. While hold exciting potential as chemical probes and therapeutic agents, development of PROTAC typically requires synthesis numerous analogs to thoroughly explore variations on linker; without extensive trial error, it is unclear how link two protein-recruiting moieties promote...
PROteolysis TArgeting Chimeras (PROTACs) are hetero-bifunctional small molecules that can simultaneously recruit target proteins and E3 ligases to form a ternary complex, promoting protein ubiquitination degradation via the Ubiquitin-Proteasome System (UPS). PROTACs have gained increasing attention in recent years due certain advantages over traditional therapeutic modalities enabling targeting of previously "undruggable" proteins. To better understand mechanism PROTAC-induced Target Protein...
Protein-protein interactions represent an exciting and challenging target class for therapeutic intervention using small molecules. Protein interaction sites are often devoid of the deep surface pockets presented by "traditional" drug targets, crystal structures reveal that inhibitors typically engage these very shallow binding modes. As a consequence, modern virtual screening tools developed to identify traditional targets do not perform as well when they instead deployed at protein sites....
Abstract PROTACs are molecules that combine a target-binding warhead with an E3 ligase-recruiting moiety; by drawing the target protein into ternary complex ligase, induce degradation. While hold exciting potential as chemical probes and therapeutic agents, development of PROTAC typically requires synthesis numerous analogs to thoroughly explore variations on linker; without extensive trial error, it is unclear how link two protein-recruiting moieties promote formation productive complex....
Abstract RNA-binding proteins (RBPs) are key post-transcriptional regulators of gene expression, and thus underlie many important biological processes. Here, we developed a strategy that entails extracting "hotspot pharmacophore" from the structure protein-RNA complex, to create template for designing small-molecule inhibitors exploring selectivity resulting inhibitors. We demonstrate this approach by Musashi MSI1 MSI2, mRNA stability translation upregulated in cancers. report novel series...
RNA-binding proteins (RBPs) are key post-transcriptional regulators of gene expression, and thus underlie many important biological processes. Here, we developed a strategy that entails extracting "hotspot pharmacophore" from the structure protein-RNA complex, to create template for designing small-molecule inhibitors exploring selectivity resulting inhibitors. We demonstrate this approach by Musashi MSI1 MSI2, mRNA stability translation upregulated in cancers. report novel series MSI1/MSI2...
In order to maximize the utility of optical scattering technology in area bacterial colony identification, it is necessary have a thorough understanding how bacteria species grow into different morphological aggregation and subsequently function as distinctive amplitude phase modulators alter incoming Gaussian laser beam. this paper, 2-dimentional reaction-diffusion (RD) model with nutrient concentration, diffusion coefficient, agar hardness variables investigated explain correlation between...
To experimentally analyze the morphological characteristics and to predict resulting scattering patterns of different bacterial colonies, an optical morphology analyzer was constructed based on a laser confocal displacement meter simultaneously obtain properties colonies. The profile data accurately captured using triangulation technology transmitted light collected by photodiode circuit. analog signals were read into acquisition board in parallel for off-line signal processing. This...