A5100643876- PARP inhibition in cancer therapy
- Cancer-related molecular mechanisms research
- Chromatin Remodeling and Cancer
- RNA modifications and cancer
- Circadian rhythm and melatonin
- DNA Repair Mechanisms
- MicroRNA in disease regulation
- Cancer Mechanisms and Therapy
- Autophagy in Disease and Therapy
- Advanced biosensing and bioanalysis techniques
- RNA Interference and Gene Delivery
- Genetics, Aging, and Longevity in Model Organisms
- Magnetic and Electromagnetic Effects
- Circular RNAs in diseases
- Cardiac Arrhythmias and Treatments
- Acute Myeloid Leukemia Research
- Cardiac electrophysiology and arrhythmias
- Effects of Environmental Stressors on Livestock
- Education and Art Integration
- Problem and Project Based Learning
- Tryptophan and brain disorders
- Electromagnetic Fields and Biological Effects
- Cancer-related gene regulation
- Cancer Cells and Metastasis
- Cell death mechanisms and regulation
Ponce Health Sciences University
2025
Pfizer-University of Granada-Junta de Andalucía Centre for Genomics and Oncological Research
2017-2023
Universidad de Granada
2005-2023
Instituto de Investigación Biomédica de Málaga
2023
Clinica Universidad de Navarra
2022
Instituto de Investigación Biosanitaria de Granada
2020
Instituto de Parasitología y Biomedicina "López - Neyra"
2008-2016
Consejo Superior de Investigaciones Científicas
2009-2015
Central University Hospital of Asturias
2015
Universidad de Zaragoza
2006
PARP inhibition can induce anti-neoplastic effects when used as monotherapy or in combination with chemo- radiotherapy various tumor settings; however, the basis for anti-metastasic activities resulting from remains unknown. inhibitors may also act modulators of angiogenesis. Proteomic analysis endothelial cells revealed that vimentin, an intermediary filament involved angiogenesis and a specific hallmark EndoMT (endothelial to mesenchymal transition) transformation, was down-regulated...
Potentials recorded at various sites in the atrioventricular (A-V) conduction system indicate that is continuously electrical nature and involves no synapse-like (i.e., chemical) conduction. The region between atrium node has slowest velocity (.05 M./sec.) lowest safety factor. Conduction through A-V about .12 M./sec. Results demonstrate shapes of potentials extracellularly within node, first degree complete block during rapid atrial stimulation, echo-like phenomena.
Abstract We assessed the effects of melatonin, N 1 ‐acetyl‐ 2 ‐formyl‐5‐methoxykynuramine (AFMK) and ‐acetyl‐5‐methoxykynuramine (AMK) on neuronal nitric oxide synthase (nNOS) activity in vitro rat striatum vivo . Melatonin AMK (10 −11 −10 −3 m ), but not AFMK, inhibited nNOS a dose–response manner. The IC 50 value for (70 µ ) was significantly lower than melatonin (>1 ). A 20% inhibition reached with either 10 −9 or AMK. inhibits by non‐competitive mechanism through its binding to Ca 2+...
Abstract: Mitochondrial nitric oxide synthase (mtNOS) produces (NO) to modulate mitochondrial respiration. Besides a constitutive mtNOS isoform it was recently suggested that mitochondria express an inducible of the enzyme during sepsis. Thus, respiratory inhibition and energy failure underlying skeletal muscle contractility observed in sepsis may reflect high levels NO produced by mtNOS. The fact is induced suggests its relation (iNOS). we examined changes activity function wild‐type (iNOS...
It is hypothesized that, besides increased free radical production, aging a process also related to inflammation. Thus, female and male senescence-accelerated (SAMP8) senescence-resistant (SAMR1) mice of 5 10 months age were studied assess this hypothesis. Plasma from these was processed determine nitric oxide (NO), pro-inflammatory [interleukin (IL)-1beta, IL-2, interferon (IFN)-gamma, tumor necrosis factor (TNF)-alpha, granulocyte-macrophage colony-stimulating factor] anti-inflammatory...
Heart mitochondria from female senescence-accelerated (SAMP8) and senescence-resistant (SAMR1) mice of 5 or 10 months age, were studied. Mitochondrial oxidative stress was determined by measuring the levels lipid peroxidation, glutathione disulfide peroxidase reductase activities. function assessed activity respiratory chain complexes ATP content. The results show that age-dependent mitochondrial damage in heart SAMP8 accompanied a reduction electron transport complex activities levels....
AMPK is a central energy sensor linking extracellular milieu fluctuations with the autophagic machinery. In current study we uncover that Poly(ADP-ribosyl)ation (PARylation), post-translational modification (PTM) of proteins, accounts for spatial and temporal regulation autophagy by modulating subcellular localisation activation. More particularly, show minority pool needs to be exported cytosol in PARylation-dependent manner optimal induction autophagy, including ULK1 phosphorylation mTORC1...
Cardiac and diaphragmatic mitochondria from male SAMP8 (senescent) SAMR1 (resistant) mice of 5 or 10 months age were studied. Levels lipid peroxidation (LPO), glutathione (GSH), GSH disulfide (GSSG), peroxidase reductase (GRd) activities measured. In addition, the effect chronic treatment with antioxidant melatonin 1 to was evaluated. show an age-dependent increase in LPO levels a reduction GSH:GSSG ratios. Chronic counteracted ratio these mitochondria. Melatonin also increased GRd activity,...
// Jara Majuelos-Melguizo 1 , María Isabel Rodríguez Laura López-Jiménez Jose M. Rodríguez-Vargas Juan Martí Martín-Consuegra Santiago Serrano-Sáenz Julie Gavard 3 J. Mariano Ruiz de Almodóvar 2 and F. Javier Oliver Instituto Parasitología y Biomedicina López Neyra, CSIC, Granada, Spain IBIMER, Centro Investigación Biomédica, Universidad CNRS, UMR8104, Paris, France Correspondence: Oliver, email: Keywords : BUBR1, Mitotic catastrophe, Glioblastoma, Homologous recombination, PARP1, PTEN,...
The dioxin (AhR) receptor can have oncogenic or tumor suppressor activities depending on the phenotype of target cell. We shown that AhR knockdown promotes melanoma primary tumorigenesis and lung metastasis in mouse human metastatic melanomas had reduced levels with respect to benign nevi. Mouse B16F10 cells were engineered by retroviral transduction stably downregulate expression, Aldh1a1 expression both. They characterized for activity, stem cell markers migration invasion vitro. Their...
Abstract Breast cancer (BC) is the most common and deadly malignant tumor in women worldwide. Triple-negative breast (TNBC) aggressive BC subtype since it associated with uncontrolled cell proliferation, genetic instability, metastasis. Advanced TNBC distant metastasis untreatable anti-hormonal or anti-HER2 therapies due to lack of hormone receptors (estrogen progesterone) Human Epidermal Growth Factor 2 receptor (HER2). Therefore, chemotherapy primary treatment for this BC. The main goal...