A5000225648- MicroRNA in disease regulation
- Immune Cell Function and Interaction
- Extracellular vesicles in disease
- Pneumonia and Respiratory Infections
- Respiratory viral infections research
- T-cell and B-cell Immunology
- Genetic factors in colorectal cancer
- Immunotherapy and Immune Responses
- RNA Research and Splicing
- Inflammasome and immune disorders
- Circular RNAs in diseases
- Immune Response and Inflammation
- Glutathione Transferases and Polymorphisms
- Emergency and Acute Care Studies
- Genomics, phytochemicals, and oxidative stress
Universidad de La Sabana
2024
Instituto de Medicina Molecular João Lobo Antunes
2024
University of Lisbon
2018-2020
Sapienza University of Rome
2014-2015
Institut d'Investigació en Ciències de la Salut Germans Trias i Pujol
2012
Notch signaling plays a complex role in carcinogenesis, and its pathway has both tumor-suppressor oncogenic components. In this study we investigated the effects of reactive oxygen species (ROS) on Notch1 outcome keratinocyte biology. We demonstrate that function contributes to arsenic-induced transformation. found acute exposure arsenite increases oxidative stress inhibits proliferation cells by upregulation p21(waf1/Cip1). The necessity p21(waf1/Cip1) for arsenite-induced cell death was...
γδ T cells are major providers of proinflammatory cytokines. They preprogrammed in the mouse thymus into distinct subsets producing either interleukin-17 (IL-17) or interferon-γ (IFN-γ), which segregate with CD27 expression. In periphery, CD27- (γδ27-) can be induced under inflammatory conditions to coexpress IL-17 and IFN-γ; molecular basis this functional plasticity remains determined. On differential microRNA (miRNA) expression analysis modulation cell subsets, we identified miR-146a as a...
Abstract CD8 + T cells are key players in immunity against intracellular infections and tumors. The main cytokine associated with these protective responses is interferon-γ (IFN-γ), whose production known to be regulated at the transcriptional level during cell differentiation. Here we found that microRNAs constitute a posttranscriptional brake IFN-γ expression by cells, since genetic interference Dicer processing machinery resulted overproduction of both thymic peripheral cells. Using gene...
Risk scores facilitate the assessment of mortality risk in patients with community-acquired pneumonia (CAP). Despite their utilities, there is a scarcity evidence comparing various RS simultaneously. This study aims to evaluate and compare multiple reported literature for predicting 30-day adult CAP.
Abstract A hallmark of autoimmune diseases like multiple sclerosis (MS) is an imbalance between CD4 + T cell subsets, namely pro-inflammatory helper 1 (Th)1 and Th17 cells, anti-inflammatory Foxp3 regulatory cells (Treg). Here we investigated which how microRNAs (miRNAs) regulate these subsets in a pre-clinical model MS. We established triple reporter mouse for Ifng , Il17 subjected it to experimental encephalomyelitis (EAE), identified the miRNomes purified Th1, Treg cells. found that...
Basic science S21 fibrosis (p = 0.004 and 0.00004), those receiving PC/TNBS had significantly less inflammation 0.009), while treated with PC/Indo/TNBS 0.001 0.03).At 6 weeks compared to TNBS alone, was not different in the Indo/TNBS PC/Indo/TNBS-treated animals, but PC/TNBS-treated animals 0.01) 0.006).The addition of PC at 2 decreased alone 0.03 0.00001), however weeks, this no effect on Indo/TNBS-induced or fibrosis.In CCD-18co cells DLPC increased MMP-1 TIMP-1 mRNA expression 0.01), Col1...