A5009532315- Microscopic Colitis
- Inflammatory Bowel Disease
- Psoriasis: Treatment and Pathogenesis
- Immunodeficiency and Autoimmune Disorders
- Immune Response and Inflammation
- Probiotics and Fermented Foods
- T-cell and B-cell Immunology
- Gastrointestinal motility and disorders
- Gut microbiota and health
- Genomic variations and chromosomal abnormalities
- Chemokine receptors and signaling
- Genetic factors in colorectal cancer
- Digestive system and related health
- Cell Adhesion Molecules Research
- Cytokine Signaling Pathways and Interactions
- Advanced biosensing and bioanalysis techniques
- Pharmacological Effects of Natural Compounds
- Neuroscience and Neuropharmacology Research
- Mycobacterium research and diagnosis
- Immunotherapy and Immune Responses
- Connective tissue disorders research
- Autoimmune and Inflammatory Disorders
- Biosimilars and Bioanalytical Methods
- Reproductive System and Pregnancy
- Asthma and respiratory diseases
Institut d'Investigació en Ciències de la Salut Germans Trias i Pujol
2008-2023
Universitat Autònoma de Barcelona
2009-2018
Banc de Sang i Teixits
2008-2018
Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas
2015
Hospital Municipal de Badalona
2015
Leiden University Medical Center
2014
Instituto Ramón y Cajal de Investigación Sanitaria
2014
Tel Aviv University
2014
Hospital Universitario de Fuenlabrada
2012
Complejo Hospitalario Universitario de Ferrol
2012
BackgroundNew techniques, such as those based on multiplex quantitative real-time PCR (MRT-PCR), can improve the detection of invasive candidiasis (IC).
Variability in genes encoding proteins involved the immunological pathways of biological therapy may account for differences observed outcomes anti–tumor necrosis factor (TNF) treatment psoriasis.To assess role 2 Fcγ receptor (FcγR) polymorphisms response to anti-TNF psoriasis.Retrospective series patients with psoriasis who received therapy(infliximab, adalimumab, or etanercept) from January 1, 2007, through December 31, 2010. Patients were followed up 12 weeks.Two referral centers.Seventy...
Background: The etiology of inflammatory bowel diseases (IBD), Crohn's disease (CD) and ulcerative colitis (UC) is yet unknown.Inflammation in UC limited to the large mucosa, thus resection was expected be curative.Nonetheless, about 50% patients undergoing total proctocolectomy with creation an ileal pouch (pouch surgery) develop small intestinal inflammation (pouchitis).We have previously shown that gene expression profiles are associated behavior IBD.One mechanism regulating protein by...
Basic science S21 fibrosis (p = 0.004 and 0.00004), those receiving PC/TNBS had significantly less inflammation 0.009), while treated with PC/Indo/TNBS 0.001 0.03).At 6 weeks compared to TNBS alone, was not different in the Indo/TNBS PC/Indo/TNBS-treated animals, but PC/TNBS-treated animals 0.01) 0.006).The addition of PC at 2 decreased alone 0.03 0.00001), however weeks, this no effect on Indo/TNBS-induced or fibrosis.In CCD-18co cells DLPC increased MMP-1 TIMP-1 mRNA expression 0.01), Col1...
Psoriasis is a common inflammatory skin disease with key immunological and genetic components. Recruitment of leukocytes into the central step in its pathogenesis, it mediated by cytokines. Among cytokines expressed psoriatic lesions, CCL4 CCL4L chemokines appear to be pivotal elements for recruitment proinflammatory cells. The aim this study evaluate relationship between polymorphisms [including Single Nucleotide Polymorphisms (SNPs) Copy Number Variation (CNV)] course prognosis...
Poster presentations was to quantify binding of CZP, IFX, ADA and ETA FcRn measure FcRn-mediated transcytosis these agents.Methods: A Biacore™ assay used determine the IFX human FcRn.Anti-TNFs were passed over an FcRn-coated chip for 5min at a range concentrations from 21 670nM on-binding rate; buffer pH 6.0 allow optimum binding.The off-rate followed further by running alone chip.MDCK II cells transfected with using 5.9 on apical side 7.2 basolateral side.The anti-TNFs control antibody...
and anti-TNF, respectively.An endoscopic recurrence (Rutgeerts score>1) was observed in 63 patients (44%).Women (OR -1,07 IC95% 0,16-0,73), with strictures -2,54; 0,01-0,81) or fistulas -2,49; 0,01-0,87) had a lower risk of recurrence, active smokers 1,46 1,90-9,74) higher recurrence.Thiopurines anti-TNF therapies, which were given more frequently to at high (accordingly the algorithm), no impact on rate whole cohort.Conclusions: This cohort exhibits classical characteristics CD undergoing...
Basic science S31 Ang1, Ang2 and Tie2 correlated with CRP, platelet count ESR. Conclusions:No or low correlation was found between ALF in serum MCS UC patients.The endoscopic activity of higher for levels than levels.Nevertheless, VEGF concentrations may be a useful non-invasive marker disease patients.
Basic science S29Conclusions: IFX acts locally at mucosa level, as shown by the decrease in inflammatory infiltrate and cytokines contents.The effect of is partially dependent on direct epithelial cells.IFX seems to ameliorate cell healing blocking detrimental capacity TNF-a pre-treated fibroblast intestinal cells.More data are necessary unravel molecular pathways these observations, order also clarify mechanisms loss responses it well new targets for potential therapies.
P447 Transcriptomic profile in Crohn’s disease with early post-surgical recurrence shows T and B cell polarisation Y. Zabana Abdo1 *, E. Pedrosa2, J. Mane3, V. Loren3, Domenech1, M. Manosa1, Troya4, Boix5, Lozano6, Cabre7. 1Hospital Universitari Germans Trias i Pujol, Department of Gastroenterology, Badalona, Spain, 2Germans Pujol Institute, Functional Genetics Unit, 3Germans Experimental Digestive Pathology 4Hospital General Surgery Department, 5Hospital Endoscopy 6CIBERehd, Bioinformatic...
Peripheral artery disease (PAD) and non-compressible (NCAD) constitute predictors of subclinical atherosclerosis easily assessed through the ankle brachial index (ABI). Although both diseases show substantial genetic influences, few association studies have focused on ABI PAD, none NCAD. To overcome these limitations, we role several candidate genes ABI, in its continuous distribution clinical manifestations associated to extreme values: PAD We examined 13 genomic regions 1606 participants...
Rationale: Standard rodent diets mostly contain n6 fatty acids (n6), which are proinflammatory and may contribute to perpetuate the experimental colitis in these animals.We previously found that dietary MCT downregulate some inflammatory mediators rats.We aimed assess 1) effect of replacing 50% fat by on course IL10(-/-) mice, 2) molecular/cellular mechanisms involved.Methods: housed pathogen-free environment, were fed with 18% energy as fat, 100% sunflower oil (n6; n=12) or oil/50% coconut...