A5035192499- Functional Brain Connectivity Studies
- Dementia and Cognitive Impairment Research
- Alzheimer's disease research and treatments
- Neural and Behavioral Psychology Studies
- Neural dynamics and brain function
- Advanced Neuroimaging Techniques and Applications
- Chromosomal and Genetic Variations
- Transcranial Magnetic Stimulation Studies
- EEG and Brain-Computer Interfaces
- Genetics and Neurodevelopmental Disorders
- Peroxisome Proliferator-Activated Receptors
- Renin-Angiotensin System Studies
- Alcohol Consumption and Health Effects
- Heavy Metal Exposure and Toxicity
- Genomic variations and chromosomal abnormalities
- Advanced MRI Techniques and Applications
- Aging, Health, and Disability
- Gastroesophageal reflux and treatments
- Attention Deficit Hyperactivity Disorder
- Memory and Neural Mechanisms
- Neuroscience and Music Perception
- Genetic Associations and Epidemiology
- Pharmacology and Obesity Treatment
- Stroke Rehabilitation and Recovery
- Tracheal and airway disorders
Sant Joan de Déu Research Foundation
2016-2025
Universitat de Barcelona
2011-2025
Institut de Recerca Sant Joan de Déu
2016-2025
Red de Investigación en Actividades Preventivas y Promoción de la Salud
2017
Open Evidence
2016
Centre de Recerca en Economia Internacional
2012
Consorci Institut D'Investigacions Biomediques August Pi I Sunyer
2002-2007
Universitat Autònoma de Barcelona
1987-2006
Victor (Japan)
2005
Hospital Clínic de Barcelona
2002
In the present study, we aimed to investigate effects of repetitive transcranial magnetic stimulation (rTMS) on memory performance and brain activity in elders presenting with subjective complaints a within low normal range. Forty participants underwent 2 functional resonance imaging (fMRI) sessions, which they were administered equivalent face–name tasks. Following each fMRI, subjects asked pair faces their corresponding proper name. In-between, high-frequency rTMS was applied randomly...
Evidence from neuroimaging and electrophysiological studies indicates that the left dorsolateral prefrontal cortex (DLPFC) is a core region in emotional processing, particularly during down-regulation of negative conditions. However, regulation process subject to major inter-individual differences, some which may be explained by personality traits. In present study we used transcranial direct current stimulation (tDCS) over DLPFC investigate whether transiently increasing activity this...
Abstract Resting‐state studies conducted with stroke patients are scarce. The study of brain activity and connectivity at rest provides a unique opportunity for the investigation rewiring after plasticity changes. This sought to identify dynamic changes in functional organization default mode network (DMN) three months stroke. Eleven (eight male female; age range: 48–72) right cortical subcortical ischemic infarctions 17 controls (eleven males six females; 57–69) were assessed by...
Abstract Cognitive flexibility, the ability to adapt goal‐oriented behaviour in response changing environmental demands, varies widely amongst individuals, yet its underlying neural mechanisms are not fully understood. Neuropharmacological and human clinical studies have suggested a critical role for striatal dopaminergic function mediated by dopamine transporter (DAT). The present study aimed at revealing of DAT individual brain stereotypy cognitive flexibility. A task‐switching protocol...
After stroke, white matter integrity can be affected both locally and distally to the primary lesion location. It has been shown that tract disruption in mirror's regions of contralateral hemisphere is associated with degree functional impairment. Fourteen patients suffering right hemispheric focal stroke (S) eighteen healthy controls (HC) underwent Diffusion Weighted Imaging (DWI) neuropsychological assessment. The patient group was divided into poor (SP; n = 8) good (SG; 6) cognitive...
Resting-state studies conducted with stroke patients are scarce. First objective was to explore whether good cognitive recovery showed differences in resting-state functional patterns of brain activity when compared poor recovery. Second determine such were correlated performance. Third assess the existence prognostic factors for Eighteen right-handed and eighteen healthy controls included study. Stroke divided into two groups according their improvement observed at three months after...
Background/Objectives: Stroke often leads to persistent cognitive and emotional impairments, which rehabilitation may mitigate. However, the biological mechanisms underlying such improvements remain unclear. This study investigated whether supplementing computerized training (CCT) with mindfulness-based stress reduction (MBSR) or physical exercise (PE) modulated biomarkers of neuroplasticity, inflammation, in patients chronic stroke compared CCT alone. We also explored biomarker changes...
Behavioral consequences of a brain insult represent an interaction between the injury and capacity rest to adapt it. We provide experimental support for notion that genetic factors play critical role in such adaptation. induced controlled disruption using repetitive transcranial magnetic stimulation (rTMS) show APOE status determines its impact on distributed networks as assessed by functional MRI (fMRI).Twenty non-demented elders exhibiting mild memory dysfunction underwent two fMRI studies...
Ischemic stroke can lead to a continuum of cognitive sequelae, ranging from mild vascular impairment dementia. These deficits be influenced by the disruption cortico-subcortical circuits. We sought explore remote thalamic microstructural abnormalities and their association with function after ischemic stroke.Seventeen patients right hemispheric 17 controls matched for age, sex, years education were included. All participants underwent neurological, neuropsychological, diffusion tensor image...
We studied the relationship among dopamine receptor D2 (DRD2) Taq I genetic polymorphism, caudate nucleus volumetry as measured using MRI and neuropsychological functions in 49 memory impaired older people. Compared with DRD2 A1 carriers, subjects homozygous for A2 allele performed poorer a measure of general cognitive functioning (MMSE) long term verbal memory, presented reduced left volumes. Caudate atrophy correlated measures influenced by polymorphism visual performance. Our findings...
OBJECTIVE: To neuropsychologically and genetically compare age‐associated memory impairment (AAMI) mild cognitive (MCI) entities to determine what proportion of AAMI diagnosed individuals could also receive a MCI diagnosis. the distribution previously known genetic risk factor for Alzheimer's disease (apolipoprotein E common polymorphism) associated with these two conditions sample normal aging. DESIGN: Neuropsychological assessments in individuals. Genetic assessment AAMI, MCI, control...
Traumatic brain injury (TBI) frequently results in cerebrovascular lesions that may increase secondary damage and cause neuropsychological impairment. Previous studies suggest an association among the insertion/deletion (I/D) polymorphism of angiotensin-converting enzyme (ACE), cardiovascular disease, cognitive performance. Clinical experimental have demonstrated beneficial effects ACE inhibitor treatment on vascular injury, hypertension, ischemia, functioning. In a sample 73 moderate severe...
Among 100 individuals with age-associated memory impairment (AAMI), APOE E4 carriers performed worse on memory. However, when subjects were considered by gender, this effect was only observed in females. may have a more robust cognitive influence female than male AAMI.
A flourishing line of evidence has highlighted the encoding speech sounds in subcortical auditory system as being shaped by acoustic, linguistic, and musical experience training. And while heritability well nonspeech processing been suggested, genetic determinants have not yet uncovered. Here, we postulated that serotonin transporter-linked polymorphic region (5-HTTLPR), a common functional polymorphism located promoter transporter gene (SLC6A4), is implicated human pathway. Serotonin shown...