A5078483998- Functional Brain Connectivity Studies
- Long-Term Effects of COVID-19
- Advanced Neuroimaging Techniques and Applications
- Stroke Rehabilitation and Recovery
- Acute Ischemic Stroke Management
- SARS-CoV-2 and COVID-19 Research
- Cerebrovascular and Carotid Artery Diseases
- Dementia and Cognitive Impairment Research
- Neuroinflammation and Neurodegeneration Mechanisms
- Parkinson's Disease Mechanisms and Treatments
- Multiple Sclerosis Research Studies
- COVID-19 and Mental Health
- COVID-19 Clinical Research Studies
- Alzheimer's disease research and treatments
- Children's Physical and Motor Development
- Physical Activity and Health
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Cardiac Health and Mental Health
- Heart Rate Variability and Autonomic Control
- Traumatic Brain Injury Research
- COVID-19 epidemiological studies
- Intensive Care Unit Cognitive Disorders
- Brain Tumor Detection and Classification
- Health, Environment, Cognitive Aging
- Cardiovascular Health and Disease Prevention
Institut d'Investigació en Ciències de la Salut Germans Trias i Pujol
2021-2025
Institut Universitari d'Investigació en Atenció Primària Jordi Gol
2021-2025
Universitat de Barcelona
2014-2024
Sant Joan de Déu Research Foundation
2024
Institut de Recerca Sant Joan de Déu
2024
Imaging Center
2023
University of Southern California
2023
Rutgers New Jersey Medical School
2020
Kessler Foundation
2020
Rutgers, The State University of New Jersey
2020
Abstract Accurate lesion segmentation is critical in stroke rehabilitation research for the quantification of burden and accurate image processing. Current automated methods T1-weighted (T1w) MRIs, commonly used research, lack accuracy reliability. Manual remains gold standard, but it time-consuming, subjective, requires neuroanatomical expertise. We previously released an open-source dataset T1w MRIs manually-segmented masks (ATLAS v1.2, N = 304) to encourage development better algorithms....
Functional outcomes after stroke are strongly related to focal injury measures. However, the role of global brain health is less clear. In this study, we examined impact age, a measure neurobiological aging derived from whole-brain structural neuroimaging, on poststroke outcomes, with focus sensorimotor performance. We hypothesized that more lesion damage would result in older which turn be associated poorer outcomes. Related, expected age mediate relationship between and Finally,...
Background The COVID-19 pandemic’s long-term mental health implications are increasingly concerning, especially among patients suffering post-acute sequelae of SARS-CoV-2 infection: Long COVID (LC) patients. Aim This study explores the presence and distribution anxiety, depression, stress in LC individuals with cognitive complaints northern Barcelona (Spain). Design & settings cross-sectional involved 155 diagnosed from “Aliança ProHEpiC-19 Cognitiu (APC)” project. Method Demographic...
Abstract Resting‐state studies conducted with stroke patients are scarce. The study of brain activity and connectivity at rest provides a unique opportunity for the investigation rewiring after plasticity changes. This sought to identify dynamic changes in functional organization default mode network (DMN) three months stroke. Eleven (eight male female; age range: 48–72) right cortical subcortical ischemic infarctions 17 controls (eleven males six females; 57–69) were assessed by...
After stroke, white matter integrity can be affected both locally and distally to the primary lesion location. It has been shown that tract disruption in mirror's regions of contralateral hemisphere is associated with degree functional impairment. Fourteen patients suffering right hemispheric focal stroke (S) eighteen healthy controls (HC) underwent Diffusion Weighted Imaging (DWI) neuropsychological assessment. The patient group was divided into poor (SP; n = 8) good (SG; 6) cognitive...
Resting-state studies conducted with stroke patients are scarce. First objective was to explore whether good cognitive recovery showed differences in resting-state functional patterns of brain activity when compared poor recovery. Second determine such were correlated performance. Third assess the existence prognostic factors for Eighteen right-handed and eighteen healthy controls included study. Stroke divided into two groups according their improvement observed at three months after...
ABSTRACT Background : No CSF or plasma biomarker has been validated for diagnosis progression of PD. Objectives To assess whether the and levels proteins associated with PD neuropathological inclusions neuroinflammation might have value in relation to disease severity. Methods α‐synuclein, amyloid‐ß1‐42, total tau, threonine‐181 phosphorylated as well cytokines (interleukin‐1ß, interleukin‐2, interleukin, interferon‐γ, tumor necrosis factor α) were studied 40 patients healthy controls....
Background: Although exercise is known to have a neuroprotective effect in aging, the mediators underlying exercise-cognition association remain poorly understood. In this paper we aimed study molecular, brain, and behavioral changes related physical activity their potential role as mediators. Methods: We obtained demographic, outcomes [sportive cardiorespiratory fitness (CRF)], plasma biomarkers (TNF-α, ICAM-1, HGF, SDF1-α, BDNF), structural-MRI (brain volume areas), psychological sleep...
<h3>BACKGROUND AND PURPOSE:</h3> There is a paucity of data on long-term neuroimaging findings from individuals who have developed the post-coronavirus 2019 (COVID-19) condition. Only 2 studies investigated correlations between cognitive assessment results and structural MR imaging in this population. This study aimed to elucidate outcomes participants with post-COVID-19 condition correlate these <h3>MATERIALS METHODS:</h3> A cohort 53 underwent 3T brain T1 FLAIR sequences obtained median...
Background The neurological symptoms of Long COVID (LC) and the impact neuropsychological manifestations on people’s daily lives have been extensively described. Although a large body literature describes symptoms, validating this with objective measures is important. This study aims to identify describe effects cognition, balance, retinal fundus, determine whether duration influences cognitive impairment. Methods cross-sectional involved LC volunteers complaint from public health centers in...
Ischemic stroke can lead to a continuum of cognitive sequelae, ranging from mild vascular impairment dementia. These deficits be influenced by the disruption cortico-subcortical circuits. We sought explore remote thalamic microstructural abnormalities and their association with function after ischemic stroke.Seventeen patients right hemispheric 17 controls matched for age, sex, years education were included. All participants underwent neurological, neuropsychological, diffusion tensor image...
Abstract Background Impulse control disorders related to alterations in the mesocorticolimbic dopamine network occur Parkinson's disease (PD). Our objective was investigate functional neural substrates of reward processing and inhibitory these patients. Methods Eighteen PD patients with impulse disorders, 17 without this complication, 18 healthy controls performed a version Iowa Gambling Task during magnetic resonance scanning under 3 conditions: positive, negative, mixed feedback....
Personality is the characteristic set of an individual's behavioral and emotional patterns that evolve from biological environmental factors. The recognition personality profiles crucial in making human-computer interaction (HCI) applications realistic, more focused, user friendly. ability to recognize using neuroscientific data underpins neurobiological basis personality. This paper aims automatically personality, combining scalp electroencephalogram (EEG) machine learning techniques. As...
Background/Objectives: Stroke often leads to persistent cognitive and emotional impairments, which rehabilitation may mitigate. However, the biological mechanisms underlying such improvements remain unclear. This study investigated whether supplementing computerized training (CCT) with mindfulness-based stress reduction (MBSR) or physical exercise (PE) modulated biomarkers of neuroplasticity, inflammation, in patients chronic stroke compared CCT alone. We also explored biomarker changes...
Introduction: Age-related health, brain and cognitive impairment is a great challenge in current society. Cognitive training, aerobic exercise their combination have been shown to benefit brain, cognition psychological status healthy older adults. Inconsistent results across studies may be related several variables. We need better identify changes, individual variables that predict the effect of these interventions changes structural functional outcomes as well physiological molecular...
Behavioral interventions have shown promising neuroprotective effects, but the cascade of molecular, brain and behavioral changes involved in these benefits remains poorly understood. Projecte Moviment is a 12-week (5 days per week-45 min day) multi-domain, single-blind, proof-of-concept randomized controlled trial examining cognitive effect underlying mechanisms an aerobic exercise (AE), computerized training (CCT) combined (COMB) groups compared to waitlist control group. Adherence was >...
Lifestyle interventions are promising strategies to promote cognitive health in aging. Projecte Moviment examines if aerobic exercise (AE), computerized training (CCT), and their combination (COMB) improves cognition, psychological health, physical status compared a control group. We assessed the moderating role of age sex mediating effects cardiorespiratory fitness (CRF), activity (PA), on intervention-related benefits.This was 12-week multi-domain, single-blind, proof-of-concept randomized...
There is a growing interest in the effect of Long-COVID (LC) on cognition, and neuroimaging allows us to gain insight into structural functional changes underlying cognitive impairment LC. We used multimodal data combination with neuropsychological evaluations study complaints cohort LC patients mild moderate severity symptoms.
<b><i>Background:</i></b> The contribution of traditional vascular risk factors to cognitive impairment and dementia is well known. However, in order obtain possible targets for prevention (VCI), it may be important identify other early noninvasive markers asymptomatic middle-aged adults. calculation middle cerebral artery-pulsatility index (MCA-PI) an ultrasonologic, noninvasive, validated easily reproducible technique assess increased distal resistance blood flow....
Lifestyle interventions have positive neuroprotective effects in aging. However, there are still open questions about how changes resting-state functional connectivity (rsFC) contribute to cognitive improvements. The Projecte Moviment is a 12-week randomized controlled trial of multimodal data acquisition protocol that investigated the aerobic exercise (AE), computerized training (CCT), and their combination (COMB). An initial list 109 participants was recruited from which total 82 (62%...
Abstract Apolipoprotein E (APOE) has an important role in the multiple trajectories of cognitive aging. However, environmental variables and other genes mediate impact APOE on cognition. Our main objective was to analyze effect genotype cognition its interactions relationships with sex, age, lipid profile, C-reactive protein, Brain-derived neurotrophic factor (BDNF) a sample 648 healthy participants over 50 years age comprehensive neuropsychological assessment. results showed that ε2...
Background Post-stroke cognitive and emotional complications are frequent in the chronic stages of stroke have important implications for functionality quality life those affected their caregivers. Strategies such as mindfulness meditation, physical exercise (PE), or computerized training (CCT) may benefit patients by impacting neuroplasticity brain health. Materials methods One hundred forty-one randomly allocated to receive mindfulness-based stress reduction + CCT ( n = 47), multicomponent...