A5073488103- Autoimmune Bullous Skin Diseases
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Urticaria and Related Conditions
- Skin and Cellular Biology Research
- Nail Diseases and Treatments
- Cancer and Skin Lesions
- Contact Dermatitis and Allergies
- Genetic and rare skin diseases.
- Platelet Disorders and Treatments
- Electromagnetic Fields and Biological Effects
- Dermatological and Skeletal Disorders
- Cutaneous lymphoproliferative disorders research
- Dermatology and Skin Diseases
- Autoimmune and Inflammatory Disorders
- Skin Diseases and Diabetes
- Cutaneous Melanoma Detection and Management
- Soft tissue tumor case studies
- Dermatologic Treatments and Research
- melanin and skin pigmentation
- Allergic Rhinitis and Sensitization
- Cell Adhesion Molecules Research
- Sarcoma Diagnosis and Treatment
- Hair Growth and Disorders
- Lymphoma Diagnosis and Treatment
- Tumors and Oncological Cases
Hankyong National University
2012-2025
Hallym University
2025
Hallym University Dongtan Sacred Heart Hospital
2025
Columbia University
2025
Yonsei University
2015-2024
Severance Hospital
2008-2024
Moffitt Cancer Center
2023
Gangnam Severance Hospital
2013-2022
Seoul National University
2012-2020
Seoul National University Hospital
2020
Immune checkpoint inhibitors (ICIs) have been shown to be beneficial for some patients with advanced non-small-cell lung cancer (NSCLC). However, the underlying mechanisms mediating limited response ICIs remain unclear.We carried out whole-exome sequencing on 198 NSCLC tumors that had sampled before anti-programmed cell death 1 (anti-PD-1)/programmed death-ligand (PD-L1) therapy. Detailed clinical characteristics were collected these patients. We designed a new method estimate human...
Recessive dystrophic epidermolysis bullosa (RDEB) is a severe skin fragility disorder caused by loss-of-function mutations in the COL7A1 gene, which encodes type VII collagen (C7), protein that functions adherence. From 36 Korean RDEB patients, we identified total of 69 pathogenic (40 variants without recurrence), including point (72.5%) and insertion/deletion (27.5%). For fibroblasts from two patients (Pat1 Pat2), applied adenine base editors (ABEs) to correct mutation or bypass premature...
The advent of costimulation blockade provides the prospect for targeted therapy with improved graft survival in transplant patients. Perhaps most effective experimental models is use reagents to block CD40/CD154 pathway. Unfortunately, successful clinical translation anti-CD154 has not been achieved. In an attempt develop agent that as previous CD154 blocking antibodies but lacks risk thromboembolism, we evaluated efficacy and safety a novel anti-human domain antibody (dAb, BMS-986004). dAb...
Epidermolysis bullosa acquisita (EBA) is a complex autoimmune bullous disease with variable clinical presentations and multiple possible diagnostic tests, making an international consensus on the diagnosis of EBA essential. To obtain criteria for EBA. The International Bullous Diseases Group (IBDG) met three times to discuss For final voting exercise, 22 experts from 14 different countries voted 50 items. When > 30% disagreed proposal, discussion was held re‐voting carried out. In total, 48...
Background and purpose We investigated changes in deep gray matter ( DGM ) volume its relationship to cognition clinical factors a large cohort of patients with neuromyelitis optica spectrum disorder NMOSD compared them results from multiple sclerosis MS ). Methods Brain magnetic resonance imaging (3 Tesla) data 91 , 52 44 healthy controls HCs were prospectively evaluated. Differences volumes among groups. The relationships between atrophy variables also analysed. Results Patients exhibited...
Adult stem cells are considered multipotent. Especially, human bone marrow-derived mesenchymal (hBM-MSCs) have the potential to differentiate into nerve type cells. Electromagnetic fields (EMFs) widely distributed in environment, and recently there been many reports on biological effects of EMFs. hBM-MSCs weak sensitive pluripotent cells, therefore extremely low frequency-electromagnetic (ELF-EMFs) could be affect changes functions within In our experiments, ELF-EMFs inhibited growth 12 days...
Background The treatment of pemphigus is still challenging and some patients with are unresponsive to conventional immunosuppressive treatments. Rituximab, a chimeric monoclonal anti‐CD20 antibody, binds the CD20 antigen on surface B cells has been reported be effective for recalcitrant pemphigus. Objective To compare efficacy different doses rituximab in who were therapies. Methods Twenty‐seven received (375 mg m−2 per infusion weekly) analysed retrospectively. We divided into two groups:...
Human bone marrow-derived mesenchymal stem cells (hBM-MSCs) are widely used in a number of cell therapies and have osteogenic differentiation capacity. Exposure to electromagnetic fields (EMFs) increases the hBM-MSCs. Nanomagnetic particles (MPs) also promote potential cells. In present study, we investigated effects EMFs MPs on hBM‑MSCs were treated with 50 µg/ml Fe3O4 or exposed frequency 45 Hz an intensity 1 mT EMF twice every 8 h per day for 7 days. MP incorporation, exposure...
Patients with recessive dystrophic epidermolysis bullosa (RDEB) exhibit blisters and erosions since birth, causing pain, pruritus various complications. RDEB affects quality of life (QoL) in physical, emotional social aspects. Furthermore, interminable dressing changes supportive therapies impose a significant economic burden on the patient's family.We assessed QoL patients RDEB.Sixteen were surveyed to assess burden. answered questionnaires consisting visual analogue scale (VAS) pain...
BACKGROUNDRecessive dystrophic epidermolysis bullosa (RDEB) is an incurable disease that causes severe mucocutaneous fragility due to mutations in COL7A1 (encoding type VII collagen [C7]). In this phase I/IIa trial, we evaluated the safety and possible clinical efficacy of intravenous infusion allogeneic human umbilical cord blood-derived mesenchymal stem cells (hUCB-MSCs) patients with RDEB.METHODSFour adult two pediatric RDEB were treated 3 injections hUCB-MSCs (1 × 106 cells/kg) every 2...
Numerous organisms use the Earth's magnetic field as a sensory cue for migration, body alignment, or food search. Despite some contradictory reports, yet it is generally accepted that humans do not sense geomagnetic field. Here, we demonstrate resonance mechanism mediates light-dependent orientation in men, using rotary chair experiment combined with two-alternative forced choice paradigm. Two groups of subjects were classified different tendencies depending on context. Magnetic was...
Refractory pruritus is the most distressing, disease-related symptom in patients with dystrophic epidermolysis bullosa (DEB), inducing an itch-scratch-blister cycle. Chronic inflammation a hallmark of DEB, thus upregulation inflammatory cytokines and Janus kinase (JAK) signaling may play role DEB-related pruritus. We retrospectively reviewed medical records DEB refractory who were treated either baricitinib, JAK1/2 inhibitor, or upadacitinib, selective JAK1 inhibitor. Patients received...
Abstract Background Epidermolysis bullosa acquisita (EBA) is a chronic autoimmune subepidermal bullous disease characterized by circulating autoantibodies against type VII collagen. Detecting these crucial for the diagnosis of this disease, and also useful measuring activity. Enzyme‐linked immunosorbent assay (ELISA), quantitative method to measure anti‐type collagen antibody levels, currently available diagnose EBA. Objective The aim study was investigate relationship ELISA with overall...
Pemphigus is a group of autoimmune blistering diseases affecting skin and mucous membranes. While pemphigus an autoantibody mediated disease, the role T cells cytokines in pathogenesis being increasingly recognized.This study was conducted to observe alterations serum cytokine levels patients with vulgaris (PV), foliaceous (PF), paraneoplastic (PNP) compare bullous pemphigoid (BP) healthy subjects.A total 75 subjects (28 PV, 13 PF, 7 PNP, BP, 20 controls) were included, all active disease...