A5005075703- Microbial Community Ecology and Physiology
- Methane Hydrates and Related Phenomena
- Oceanographic and Atmospheric Processes
- Climate change and permafrost
- Genetics, Aging, and Longevity in Model Organisms
- Genomics and Phylogenetic Studies
- Metal Extraction and Bioleaching
- RNA modifications and cancer
- Climate variability and models
- Mine drainage and remediation techniques
- Echinoderm biology and ecology
- Immune Cell Function and Interaction
- T-cell and B-cell Immunology
- RNA Research and Splicing
- Cancer-related gene regulation
- CRISPR and Genetic Engineering
- Ocean Waves and Remote Sensing
- Atherosclerosis and Cardiovascular Diseases
- Geology and Paleoclimatology Research
- Arctic and Antarctic ice dynamics
- Epigenetics and DNA Methylation
- Tropical and Extratropical Cyclones Research
- Chinese history and philosophy
- Histone Deacetylase Inhibitors Research
- Efficiency Analysis Using DEA
Wenzhou Medical University
2025
First Affiliated Hospital of Wenzhou Medical University
2025
Huazhong University of Science and Technology
2011-2024
Tongji Hospital
2011-2024
South China Sea Institute Of Oceanology
2018-2024
Chinese Academy of Sciences
2015-2024
Guangzhou Institutes of Biomedicine and Health
2024
Institute of Oceanology
2018-2024
University of Tennessee at Knoxville
2019-2024
Institut de Biologie Intégrative de la Cellule
2024
Epigenetic alteration has been implicated in aging. However, the mechanism by which epigenetic change impacts aging remains to be understood. H3K27me3, a highly conserved histone modification signifying transcriptional repression, is marked and maintained Polycomb Repressive Complexes (PRCs). Here, we explore age-modulated increase of H3K27me3 adult lifespan. Using
Abstract Microorganisms in the terrestrial deep biosphere host up to 20% of earth’s biomass and are suggested be sustained by gases hydrogen carbon dioxide. A metagenome analysis three subsurface water types contrasting age (from <20 several thousand years) depth (171 448 m) revealed phylogenetically distinct microbial community subsets that either passed or were retained a 0.22 μm filter. Such cells <0.22 would have been overlooked previous studies relying on membrane capture....
Little research has been conducted on microbial diversity deep under the Earth's surface. In this study, communities of three terrestrial subsurface aquifers were investigated. Temporal community data over 6 years revealed that phylogenetic structure and dynamics highly dependent degree isolation from earth surface biomes. The at shallow site was most dynamic dominated by sulfur-oxidizing genera Sulfurovum or Sulfurimonas all-time points. in meteoric water filled intermediate aquifer (water...
Abstract Cellular senescence is characterized by a decrease in protein synthesis, although the underlying processes are mostly unclear. Chemical modifications to transfer RNAs (tRNAs) frequently influence tRNA activity, which crucial for translation. We describe how N7-methylguanosine (m7G46) methylation, catalyzed METTL1-WDR4, regulates translation and influences phenotypes. Mettl1/Wdr4 m7G gradually diminish with aging. A METTL1 causes reduction tRNAs, especially those modification, via...
CD28null T cells, an atypical subset characterized by the loss of CD28 costimulatory molecule expression, exhibit functional variants and progressively expand with age. Moreover, cells these phenotypes are found in both typical humoral immune responses. Consequently, they accumulate during infectious diseases, autoimmune disorders, cardiovascular conditions, neurodegenerative ailments. To provide in-depth review current knowledge regarding we specifically focus on their phenotypic...
In eukaryotes, aberrant expression of transposable elements is detrimental to the host genome. Piwi-interacting RNAs ∼23 30 nucleotides (nt) bound PIWI-clade Argonaute proteins silence transposons strictly dependent on their sequence complementarity. Hence, a key question in understanding piRNA pathways determine mechanisms that modulate sequences. Here, we identify protein-protein interaction between Nibbler (Nbr), 3'-to-5' exoribonuclease and Piwi, linking Nbr activity with pathways. We...
FOXO transcription factors have long been associated with longevity control and tissue homeostasis. Although the transcriptional regulation of previously characterized (especially in long-lived insulin mutants under stress conditions), how normal aging impacts activity is poorly understood. Here, we conducted a chromatin immunoprecipitation sequencing (ChIP-Seq) analysis both young (2-week-old) aged (5-week-old) wild-type female fruit flies, Drosophila melanogaster, to evaluate dynamics gene...
A newly designed sampling apparatus was used to fix RNA under in situ conditions the deep continental biosphere and benchmarks a strategy for metatranscriptomic sequencing. This enabled identification of active community members processes they carry out this extremely oligotrophic environment. work presents first time evidence eukaryotic, archaeal, bacterial activity two subsurface crystalline rock groundwaters from Äspö Hard Rock Laboratory with different depths geochemical characteristics....
This study describes the composition and potential metabolic adaptation of microbial communities in northeastern Siberia, a repository oldest permafrost Northern Hemisphere. Samples contrasting depth (1.75 to 25.1 m below surface), age (from ~ 10 kyr 1.1 Myr) salinity low 0.1-0.2 ppt brackish 0.3-1.3 saline 6.1 ppt) were collected from freshwater (FP) borehole AL1_15 on Alazeya River, coastal (BP) overlying marine (MP) CH1_17 East Siberian Sea coast. To avoid limited view provided with...
Soils containing an approximately equal mixture of metastable iron sulfides and pyrite occur in the boreal Ostrobothnian coastal region Finland, termed ‘potential acid sulfate soil materials’. If are exposed to air, oxidation reactions result metal release environment that can cause severe damage. Despite acidophilic microorganisms catalyze from sulfide minerals, microbiology (ASS) materials has been neglected. The molecular phylogeny a depth profile through plough oxidized ASS layers...
Deep terrestrial biosphere waters are separated from the light-driven surface by time required to percolate subsurface. Despite biofilms being dominant form of microbial life in many natural environments, they have received little attention oligotrophic and anaerobic found deep bedrock fractures. This study is first use community DNA sequencing describe biofilm formation under situ conditions biosphere. In this study, flow cells were attached boreholes containing either "modern marine" or...
Abstract The deep biosphere contains members from all three domains of life along with viruses. Here we investigate the terrestrial virosphere by sequencing community nucleic acids groundwaters contrasting chemistries, origins, and ages. These viromes constitute a highly unique compared to other environmental sequenced viral isolates. Viral host prediction suggests that many viruses are associated Firmicutes Patescibacteria, superphylum lacking previously described active RNA...
Patients with colorectal cancer (CRC) often present malnutrition upon admission, which is associated a poor prognosis. However, current traditional tools for diagnosing do not assess muscle function. This study aims to explore whether the evaluation of function has predictive value prognosis CRC patients malnutrition. We retrospectively analyzed clinical parameters and based on Global Leadership Initiative Malnutrition criteria who underwent radical surgery at our center from 2015 2021. were...
The deep biosphere is the largest 'bioreactor' on earth, and microbes inhabiting this biome profoundly influence global nutrient energy cycles. An important question for microbiology whether or not specific populations are viable. To address this, we used quantitative PCR high throughput 16S rRNA gene sequencing of total viable cells (i.e. with an intact cellular membrane) from three groundwaters different ages chemical constituents. There were no statistically significant differences in...
Abstract Background The sea cucumber Holothuria leucospilota belongs to echinoderm, which is evolutionally the most primitive group of deuterostomes. Sea has a cavity between its digestive tract and body wall that filled with fluid suspended coelomic cells similar blood cells. humoral immune response based on secretion various factors from coelomocytes into cavity. aim this study lay out foundation for mechanisms in echinoderms their origins chordates by using RNA-seq. Results primary were...