A5054657937- Neuroscience and Neuropharmacology Research
- Neurotransmitter Receptor Influence on Behavior
- Receptor Mechanisms and Signaling
- Medical Imaging Techniques and Applications
- Memory and Neural Mechanisms
- Neural dynamics and brain function
- Cytokine Signaling Pathways and Interactions
- Cancer, Hypoxia, and Metabolism
- Radiomics and Machine Learning in Medical Imaging
- Neuroscience and Music Perception
- Pain Mechanisms and Treatments
- Biochemical Analysis and Sensing Techniques
- Multiple Sclerosis Research Studies
- Radiopharmaceutical Chemistry and Applications
- Cannabis and Cannabinoid Research
- Folate and B Vitamins Research
- Neuroinflammation and Neurodegeneration Mechanisms
- Sphingolipid Metabolism and Signaling
- Psoriasis: Treatment and Pathogenesis
- Dermatology and Skin Diseases
- Pharmacological Effects and Toxicity Studies
- Olfactory and Sensory Function Studies
- Nicotinic Acetylcholine Receptors Study
- Neuropeptides and Animal Physiology
- Stress Responses and Cortisol
Fraunhofer Institute for Translational Medicine and Pharmacology
2016-2023
Medical University of Vienna
2022
The Netherlands Cancer Institute
2021
Fraunhofer Institute for Molecular Biology and Applied Ecology
2014-2020
Abbott (Netherlands)
2011-2017
Solvay (Netherlands)
2010-2017
Institute of Molecular Biology
2014-2017
Goethe University Frankfurt
2014-2015
Fraunhofer Society
2014
Solvay (Belgium)
2013
Significance Chemotherapy-induced peripheral neuropathic pain (CIPNP) is a severe side effect that affects up to 80% of patients during cancer treatment. Pharmacological treatment options are poor, as CIPNP differs mechanistically from other chronic states. Here, we describe mechanism by which pronociceptive oxidized lipid mediators generated the cytochrome P 450 -epoxygenase CYP2J2 in sensory neurons CIPNP. Blocking synthesis these lipids with telmisartan, identified potent inhibitor large...
Highlights•IL-38-deficient mice display delayed resolution of imiquimod-induced psoriasis•IL-38 suppresses IL-17A production by γδ T cells•Inhibition cells requires IL1RAPL1•IL1RAPL1-deficient show decreased cell activation during psoriasisSummaryInterleukin-38 (IL-38) is a cytokine the IL-1 family with role in chronic inflammation. However, its main cellular targets and receptors remain obscure. IL-38 highly expressed skin downregulated psoriasis patients. We report an investigation...
While high risk of failure is an inherent part developing innovative therapies, it can be reduced by adherence to evidence-based rigorous research practices. Supported through the European Union’s Innovative Medicines Initiative, EQIPD consortium has developed a novel preclinical quality system that applied in both public and private sectors free for anyone use. The Quality System was designed suited boost innovation ensuring generation robust reliable data while being lean, effective not...
Slack (Slo2.2) is a sodium-activated potassium channel that regulates neuronal firing activities and patterns. Previous studies identified in sensory neurons, but its contribution to acute chronic pain vivo remains elusive. Here we generated global neuron-specific mutant mice analyzed their behavior various animal models of pain. Global ablation led increased hypersensitivity neuropathic pain, whereas the inflammatory nociceptive was normal. Neuropathic behaviors were also exaggerated after...
Neuropathic pain is experienced worldwide by patients suffering from nerve injuries, infectious or metabolic diseases chemotherapy. However, the treatment options are still limited because of low efficacy and sometimes severe side effects. Recently, deficiency FKBP51 was shown to relieve chronic pain, revealing as a potential therapeutic target. specific potent inhibitor not available until recently which hampered targeting FKBP51.In this study, we used well-established robust spared injury...
Bioactive lipids contribute to the pathophysiology of multiple sclerosis. Here, we show that lysophosphatidic acids (LPAs) are dysregulated in sclerosis (MS) and functionally relevant this disease. LPAs autotaxin, major enzyme producing extracellular LPAs, were analyzed serum cerebrospinal fluid a cross-sectional population MS patients compared with respective data from mice experimental autoimmune encephalomyelitis (EAE) model, spontaneous EAE TCR1640 mice, Lpar2 -/- mice. Serum reduced...
Platelets are well known for their role in hemostasis but also increasingly recognized supporting innate immune responses. Here, we studied the of platelets development peripheral inflammation and found that colocalize with macrophages inflamed tissue outside blood vessels different animal models cutaneous inflammation. Collagen-treatment isolated from paws during zymosan-induced induced thromboxane synthesis through platelet-expressed collagen receptor glycoprotein VI. Deletion VI or its...
SARS-CoV-2 uses the human cell surface protein angiotensin converting enzyme 2 (ACE2) as receptor by which it gains access into lung and other tissue. Early in pandemic, there was speculation that a number of commonly used medications-including ibuprofen non-steroidal anti-inflammatory drugs (NSAIDs)-have potential to upregulate ACE2, thereby possibly facilitating viral entry increasing severity COVID-19. We investigated influence NSAIDS with range cyclooxygenase (COX)1 COX2 selectivity...
The 5-HT(6) receptor (5-HT(6)R) has been in the spotlight for several years regarding CNS-related diseases. We set out to discover novel, neutral 5-HT(6)R antagonists improve off-target selectivity compared basic amine-containing scaffolds dominating field. High-throughput screening identified N'-(sulfonyl)pyrazoline-1-carboxamidine scaffold as a promising core starting hit-to-lead. Medicinal chemistry, molecular modeling, small molecule NMR and X-ray crystallography were subsequently...
Multiple sclerosis is presumed to be an inflammatory autoimmune disease, which characterized by lesion formation in the central nervous system (CNS) resulting cognitive and motor impairment. Experimental encephalomyelitis (EAE) a useful animal model of MS, because it also CNS, impairment driven reactions. One EAE models induced with peptide derived from myelin oligodendrocyte protein (MOG)35-55 mice. The mice develop progressive disease course. This course divided into three phases:...
The development and manufacture of novel nanocarriers for drug delivery has proved challenging with regards to scale-up pharmaceutical quality. Polymeric composed poly(lactic-co-glycolic acid)-b-poly(ethylene glycol) (PLGA–PEG) were prepared the photosensitizer meso-tetrakis(3-hydroxyphenyl) chlorin (mTHPC) was effectively encapsulated. Furthermore, interplay various process formulation parameters their impact on most important product specifications investigated by using a factorial design...
Sensitization of the heat-activated ion channel transient receptor potential vanilloid 1 (TRPV1) through lipids is a fundamental mechanism during inflammation-induced peripheral sensitization. Leukotriene B4 proinflammatory lipid mediator whose role in nociceptive sensitization not well understood to date. Two major G-protein-coupled receptors for leukotriene have been identified: high-affinity BLT1 and low-affinity BLT2. Transcriptional screening expression murine dorsal root ganglia showed...