A5048116382- Ubiquitin and proteasome pathways
- Cancer, Hypoxia, and Metabolism
- Cancer-related Molecular Pathways
- Cancer-related gene regulation
- Epigenetics and DNA Methylation
- Pluripotent Stem Cells Research
- RNA modifications and cancer
- 3D Printing in Biomedical Research
- NF-κB Signaling Pathways
- RNA Interference and Gene Delivery
- Long-Term Effects of COVID-19
- Protein Degradation and Inhibitors
- interferon and immune responses
- CRISPR and Genetic Engineering
- COVID-19 Clinical Research Studies
- Protein Kinase Regulation and GTPase Signaling
- Smart Agriculture and AI
- Histone Deacetylase Inhibitors Research
- Protease and Inhibitor Mechanisms
- Image Processing Techniques and Applications
- Signaling Pathways in Disease
- Cytokine Signaling Pathways and Interactions
- Cellular Mechanics and Interactions
- ECG Monitoring and Analysis
- FOXO transcription factor regulation
University of Padua
2024
Institute of Genetics and Biophysics
2007-2023
National Research Council
2011-2023
Institut Pasteur
2007
Instituto di Biofisica
1997
University of Milan
1996
Abstract Aims The last released European guidelines on the management of heart failure (HF) recommend in patients with chronic HF reduced ejection fraction (HFrEF) a pharmacological approach based four fundamental drugs to be rapidly implemented and then uptitrated modify disease progression. aim Optimization Therapy Italian Management Heart Failure (OPTIMA‐HF) registry is collect data outpatients different settings care. In present analysis, we report first analysis OPTIMA‐HF registry,...
The molecular mechanisms controlling mouse embryonic stem cell (ESC) metastability, i.e. their capacity to fluctuate between different states of pluripotency, are not fully resolved. We developed and used a novel automation platform, the Cellmaker, screen library metabolites on two ESC-based phenotypic assays (i.e. proliferation colony phenotype) identified metabolically related amino acids, namely l-proline (l-Pro) l-ornithine (l-Orn), as key regulators ESC metastability. Both compounds,...
Increasing evidence indicates that metabolism is implicated in the control of stem cell identity. Here, we demonstrate embryonic (ESC) behaviour relies on a feedback loop involves non-essential amino acid L-Proline (L-Pro) modulation Gcn2-Eif2α-Atf4 starvation response (AAR) pathway turn regulates L-Pro biosynthesis. This regulatory generates highly specific intrinsic shortage restricts proliferation tightly packed domed-like ESC colonies and safeguards Indeed, alleviation this nutrient...
The initial conditions for morphogenesis trigger a cascade of events that ultimately dictate structure and functions tissues organs. Here we report surface nanopatterning can control the assembly focal adhesions, hence guiding human mesenchymal stem cells (hMSCs) through process self-organization differentiation. This self-sustains, leading to development macroscopic with molecular profiles microarchitecture reminiscent embryonic tendons. Therefore, material surfaces be in principle...
Abstract Collagen prolyl hydroxylation (CPH), which is catalyzed by 4-hydroxylase (P4H), the most prevalent posttranslational modification in humans and requires vitamin C (VitC). Here, we demonstrate that CPH acts as an epigenetic modulator of cell plasticity. Increased induced global DNA/histone methylation pluripotent stem tumor cells promoted state transition (CST). Interfering with either genetic ablation P4H subunit alpha-2 (P4HA2) or pharmacologic treatment reverted changes...
The AP-1 transcription factor plays an essential role in cell proliferation and tumorigenesis. It was previously shown that the fra-1 gene product is upregulated by various oncogenes involved vitro vivo transformation of thyroid cells. Here we show ras oncogene-dependent accumulation Fra-1 mediated a positive feedback mechanism which requires both transcriptional autoregulation posttranslational stabilization protein. activation involves cooperation between Raf-dependent Raf-independent...
Many data were published about Long-Covid prevalence, very few the findings of new cardiac alterations (NCA) in COVID-19-recovered people.
We have investigated the in vivo and vitro regulation of human urokinase-type plasminogen activator (uPA) gene by interleukin-1 (IL-1) analyzed transcription factors signalling pathways involved response -2.0-kb uPA enhancer to IL-1 induction tetradecanoyl phorbol acetate (TPA) induction. Mutational analysis showed cooperative activity Ets-binding site (EBS) two AP-1 elements enhancer. The results reveal that EBS is required for both inducers mediated Ets-2, which regulated at a level...
Abstract Most models of language comprehension assume that the linguistic system is able to pre-activate phonological information. However, evidence for prediction mixed and controversial. In this study, we implement a paradigm capitalizes on fact foreign speakers usually make errors. We investigate whether speaker identity (native vs. foreign) used specific predictions. Fifty-two participants were recruited read sentence frames followed by last spoken word which was uttered either native or...
Exploitation of embryonic stem cells (ESC) for therapeutic use and biomedical applications is severely hampered by the risk teratocarcinoma formation. Here, we performed a screen selected epi-modulating compounds demonstrate that transient exposure mouse ESC to MS-275 (Entinostat), class I histone deacetylase inhibitor (HDAC), modulates differentiation prevents Morphological molecular data indicate MS-275-primed ESCs are committed towards neural differentiation, which supported transcriptome...
Binding sites for different transcription factors have been identified in the regulatory region of human uPA gene. We investigated role NF‐κB and AP‐1 families induction mRNA by TNF‐α PMA A549 cell line constitutively expressing protein. Using protein synthesis inhibitor cycloheximide antioxidant PDTC, that an opposite effect on activation, we showed is mainly due to activation.