A5101676774- Pancreatic and Hepatic Oncology Research
- Gut microbiota and health
- Diet and metabolism studies
- Cancer Immunotherapy and Biomarkers
- Immune Cell Function and Interaction
- Epigenetics and DNA Methylation
- Immunotherapy and Immune Responses
- Autophagy in Disease and Therapy
- Cancer, Hypoxia, and Metabolism
- RNA modifications and cancer
- Cancer Cells and Metastasis
- Colorectal Cancer Surgical Treatments
- Cancer-related molecular mechanisms research
- Cancer Genomics and Diagnostics
- Cancer Mechanisms and Therapy
- Radiomics and Machine Learning in Medical Imaging
- Adipose Tissue and Metabolism
- Genetic factors in colorectal cancer
- Hippo pathway signaling and YAP/TAZ
- Medical Imaging and Analysis
- Inflammatory Biomarkers in Disease Prognosis
- Ferroptosis and cancer prognosis
- Wnt/β-catenin signaling in development and cancer
- Cancer-related Molecular Pathways
- Neuroendocrine Tumor Research Advances
Soochow University
2015-2025
First Affiliated Hospital of Soochow University
2014-2025
Wenzhou Medical University
2023
Zhejiang Taizhou Hospital
2023
Soochow University
2021
Peking University First Hospital
2019
Peking University
2019
Shanghai First People's Hospital
2018
Shanghai Jiao Tong University
2014-2018
Atkins (United States)
2016
This study was designed to investigate the distribution of Th17 cells in tumor microenvironment and peripheral blood pancreatic cancer patients, its clinical significance, expression profile cell-associated cytokines. The percentage detected by flow cytometry analysis (FACS) significantly higher 46 tissues (5.28 ± 1.65%) compared with corresponding adjacent normal (2.57 0.83%) (P = 0.031). In addition, stage III-IV tumors than I-II 0.039). 20 patients (3.99 1.15%) 15 healthy volunteers (1.98...
Postoperative chemotherapy for Colorectal cancer (CRC) patients is not all effective and the main reason might lie in stem cells (CSCs). Emerging studies showed that CSCs overexpress some drug-resistance related proteins, which efficiently transport chemotherapeutics out of cells. Salinomycin, considered as a novel an anticancer drug, found to have ability kill both therapy-resistant To explore potential mechanisms salinomycin could specifically target on colorectal cancers, we firstly...
We investigated the clinicopathologic significance of HIF-1, CXCR4, and VEGF expression using immumohistochemistry in human colon cancer. high levels were correlated positively with TNM stage, lymph node involvement, distant metastasis Furthermore, we found that combined any two three molecules (P = .028 for HIF-1/CXCR4, P .007 HIF-1/VEGF, .004 CXCR4/VEGF) had stronger correlation than did each alone. However, a relationship is seen only combinations CXCR4/VEGF .069 .062 .035 as compared...
Recent research has revealed a role for Ambra1, an autophagy-related gene-related (ATG) protein, in the autophagic pro-survival response, and Ambra1 been shown to regulate Beclin1 Beclin1-dependent autophagy embryonic stem cells. However, whether plays important pathway colorectal cancer cells is unknown. In this study, we hypothesized that regulator of apoptosis CRC cell lines. To test hypothesis, confirmed activity serum-starved SW620 by assessing endogenous microtubule-associated protein...
Accumulating evidence illustrates that sirtuins (SIRTs) regulate autophagy and apoptosis in cancer cells; however, the role of SIRT5 gastric (GC) cells remains unknown. In this study, we examined GC cells.We detected protein levels freshly collected samples from patients with GC. Next, studied function autophagy. Furthermore, signaling pathway through which enhanced was detected. addition, established a cell model to analyze apoptosis.SIRT5 expression downregulated tissues. We discovered...
BACKGROUND: Accurate prediction of response to neoadjuvant chemoradiotherapy is critical for subsequent treatment decisions patients with locally advanced rectal cancer. OBJECTIVE: To develop and validate a deep learning model that based on the comparison paired magnetic resonance imaging before after predict pathological complete response. DESIGN: By capturing changes from images in 638 patients, we trained multitask (DeepRP-RC) also allowed simultaneous segmentation. Its performance was...
Abstract Metabolic reprogramming is considered one of the hallmarks cancer in which cells reprogram some their metabolic cascades, mostly driven by specific chemical microenvironment tissues. The altered pathways are increasingly being as potential targets for therapy. In this view, Aldolase A (ALDOA), a key glycolytic enzyme, has been validated candidate oncogene several cancers. current study aimed to investigate role ALDOA initiation and development colorectal (CRC). study, we observed an...
Acyl-CoA oxidase 1 (ACOX1), a member of the acyl-coenzyme A family, is considered crucial regulator whose dysregulation implicated in occurrence and progression various cancers. This study aims to elucidate impact ACOX1 CRC, shedding light on its potential as therapeutic target. Through analysis GEO dataset, it was found that significantly downregulated colorectal cancer (CRC), this lower expression level associated with worse prognosis. Additionally, vitro well vivo, overexpression...
Abstract Background To investigate whether dendritic cell (DC) precursors, recruited by injection of chemokine ligand 3 (CCL3) and CCL20 , induce anti-tumor immunity against gastric cancer induced a DC vaccine expressing melanoma antigen gene-1 (MAGE-1) ex vivo in vivo. Methods B6 mice were injected with CCL3 via the tail vein. Freshly isolated F4/80 - B220 CD11c + cells cultured cytokines analyzed phenotype analysis mixed lymphocyte reaction (MLR). For adenoviral (Ad)-mediated gene...
<p>S3. In AOM/DSS model mice, antibiotic treatment significantly attenuated the colon tumorigenesis.</p>
<p>S8. IHC staining of NRF2 in the normal BCAA diet group and low group.</p>
<p>Figure S7. Mass spectrometry analysis of the BCAT2, keratin 19 and ACOT7 peptides pulled down by antisense circ_0126925 probes.</p>
<div>Abstract<p>Recent evidence indicates that a high-fat diet can promote tumor development, especially colorectal cancer, by influencing the microbiota. Regulatory circular RNA (circRNA) plays an important role in modulating host–microbe interactions; however, specific mechanisms which circRNAs influence cancer progression regulating these interactions remain unclear. Here, we report consumption of modulates microbiota specifically upregulating expression noncoding...
<p>S4. HFD-modulated gut microbiota of mice and obese patients promote malignant progression colorectal tumors in Abx pretreated AOM/DSS model mice.</p>
<p>S5. <i>In vitro</i>, circ_38945 promotes proliferation and migration.</p>
<p>S6. Stable cells with circ_0126925 knockdown or overexpression.</p>
<p>S2. IF of the tight junction proteins ZO-1 and Occludin in AOM/DSS model mice subjected to three different treatment methods IHC staining Ki-67 colon two methods.</p>