A5104316458- Cancer Immunotherapy and Biomarkers
- Ferroptosis and cancer prognosis
- Remote Sensing in Agriculture
- Remote Sensing and LiDAR Applications
- Infectious Diseases and Mycology
- Inflammatory Biomarkers in Disease Prognosis
- Immune cells in cancer
- Lung Cancer Treatments and Mutations
- Vector-borne infectious diseases
- Remote Sensing and Land Use
- Actinomycetales infections and treatment
- Myxozoan Parasites in Aquatic Species
- Radiomics and Machine Learning in Medical Imaging
- Smart Agriculture and AI
- Psoriasis: Treatment and Pathogenesis
- Gut microbiota and health
- Neurobiology and Insect Physiology Research
- Single-cell and spatial transcriptomics
- Sleep and Wakefulness Research
- Hereditary Neurological Disorders
- Congenital Heart Disease Studies
- Endoplasmic Reticulum Stress and Disease
- Bone and Joint Diseases
- Power Line Inspection Robots
- Sesquiterpenes and Asteraceae Studies
Nanjing Medical University
2021-2025
Inner Mongolia Agricultural University
2021-2025
Jiangsu Cancer Hospital
2021-2025
Jiaxing University
2021-2024
Zhejiang Chinese Medical University
2023-2024
Fuzhou University
2021-2023
National Medical Products Administration
2022
China Southern Power Grid (China)
2022
Zhejiang University
2018-2021
Bengbu Medical College
2021
Rapid and accurate discrimination of Chrysanthemum varieties is very important for producers, consumers market regulators. The feasibility using hyperspectral imaging combined with deep convolutional neural network (DCNN) algorithm to identify was studied in this paper. Hyperspectral images the spectral range 874⁻1734 nm were collected 11,038 samples seven varieties. Principal component analysis (PCA) introduced qualitative analysis. Score first five PCs used explore differences between...
Background Hepatocellular carcinoma (HCC) is the most common pathological type of primary liver cancer. The lack prognosis indicators one challenges in HCC. In this study, we investigated combination tertiary lymphoid structure (TLS) and several systemic inflammation parameters as a indicator for Materials Methods We retrospectively recruited 126 postoperative patients with paraffin section was collected TLS density assessment. addition, from peripheral blood samples. evaluated prognostic...
Fractional vegetation cover (FVC) is the key trait of interest for characterizing crop growth status in breeding and precision management. Accurate quantification FVC among different lines, cultivars, environments challenging, especially because large spatiotemporal variability complex field conditions. This study presents an ensemble modeling strategy phenotyping from unmanned aerial vehicle (UAV)-based multispectral images by coupling PROSAIL model with a gap probability (PROSAIL-GP)....
Background PD-1 inhibitors have been routinely used in the treatment of advanced non-small cell lung cancer (NSCLC), and demonstrated to significantly improve survivorship when combining with other conventional therapies, such as chemotherapy anti-angiogenesis therapy. PD-L1 is most commonly biomarker select benefiting groups, while not all patients high expression benefit from immunotherapy. Therefore, identifying prognostic predictive biomarkers, including peripheral blood indexes,...
Animal influenza viruses pose a danger to the general public. Eurasian avian-like H1N1 (EA H1N1) have recently infected humans in several different countries and are often found pigs China, indicating that they potential cause pandemic. Therefore, there is an urgent need develop potent vaccine against EA H1N1. In this study, we report effective intramuscular (i.m.) and/or intranasal (i.n.) vaccination of mice with subunit utilizing safe adjuvant gram-positive enhancer matrix (GEM) particles...
Epidermal growth factor receptor (EGFR) sensitive mutation is one of the effective targets targeted therapy for non-small cell lung cancer (NSCLC). However, due to difficulty obtaining some primary tissues and economic factors in underdeveloped areas, patients cannot undergo traditional genetic testing. The aim this study establish a machine learning (ML) model using non-invasive peripheral blood markers explore biomarkers closely related EGFR status NSCLC evaluate their potential prognostic...
Lung adenocarcinoma (LUAD) is one of the most common tumors in terms incidence and mortality worldwide. Posttranslational modifications, including crotonylation, play a crucial role various biological processes diseases. However, crotonylation LUAD remains unclear. Our research focuses on identifying key genes that are linked to prognosis. We also aim clarify their microenvironment advance clinical translation related targets. used RNA-sequencing data from The Cancer Genome Atlas (TCGA)...
Programmed Cell Death-1/ Death-ligand 1 (PD-1 / PD-L1) inhibitor therapies targeting immunocytes induce persistent tumor remission in various cancers. However, the appropriate biomarkers for therapeutic efficacy of PD-L1 and PD-1 blockade remain elusive.For a comprehensive analysis peri-treatment lymphocyte differentiation, current study, we enrolled 146 non-small cell lung cancer patients who received α-PD-1 exploring peripheral blood differentiation pattern at baseline post-treatment...
Abstract Background Maedi-visna virus (MVV) is a lentivirus that infects monocyte/macrophage lineage cells in sheep, goats, and wild ruminants causes pneumonia, mastitis, arthritis, encephalitis. The immune response to MVV infection complex, complete understanding of its pathogenesis lacking. This study investigated the vivo transcriptomic patterns lung tissues sheep exposed using RNA sequencing technology. Result results indicated 2,739 genes were significantly differentially expressed,...
Lung cancer is among the major diseases threatening human health. Although immune response plays an important role in tumor development, its exact mechanisms are unclear.Here, we used CIBERSORT and ESTIMATE algorithms to determine proportion of tumor-infiltrating cells (TICs) as well number mesenchymal components from data 474 lung patients Gene Expression Omnibus database. And The Cancer Genome Atlas database (TCGA) for validation.We observed that immune, stromal, assessment scores were...
Abstract Background Pulmonary arterial hypertension is a common complication in patients with congenital heart disease. In the absence of early diagnosis and treatment, pediatric PAH has poor survival rate. Here, we explore serum biomarkers for distinguishing children pulmonary associated disease (PAH-CHD) from CHD. Methods Samples were analyzed by nuclear magnetic resonance spectroscopy-based metabolomics 22 metabolites further quantified ultra-high-performance liquid chromatography–tandem...
Abstract Cancer stem cells (CSCs) are believed to be crucial in the initiation, progression, and recurrence of cancer. CSCs also known more resistant cancer treatments. However, interaction between immune microenvironment is complex not fully understood. In current study we used single cell RNA sequence (scRNA-Seq, public dataset) technology identify characteristic CSCs. We found that lung adenocarcinoma population highly inflammatory remodels tumor by secreting factors, specifically acute...
BackgroundMalignant tumours, particularly non-small cell lung cancer (NSCLC), pose a significant threat to human health due their prevalence and lethality. Treatment methods for NSCLC vary greatly among individuals, making it crucial identify predictive markers. Moreover, during tumour initiation progression, cells can release signaling molecules induce polarization of macrophages towards more friendly M2 phenotype, which promote growth, metastasis, drug resistance.MethodsWe employed...
Immunotherapy deeply changed the treatment paradigm of advanced non-small cell lung cancer (NSCLC) in past years. However, objective response rate (ORR) after immunotherapy is about 20-30% NSCLC patients. Therefore, identification predictive biomarkers crucial for selecting patients with who would most benefit from programmed death receptor protein 1 (PD-1) inhibitor-based immunotherapy.We retrospectively collected medical records and thioredoxin reductase (TrxR) data 90 a received PD-1...
Citation: Du X Y, Wan L, Cen H Chen S B, Zhu J P, Wang He Y.  Multi-temporal monitoring of leaf area index rice under different nitrogen treatments using UAV images. Int Precis Agric Aviat, 2020; 3(1): 7–12.
Despite the recognized therapeutic potential of programmed cell death protein 1/programmed death-ligand 1 (PD-1/PD-L1) inhibitors in advanced esophageal squamous carcinoma (ESCC), their role neoadjuvant therapy and reliable efficacy biomarkers remain elusive.
Objective: Serum uric acid is associated with tumor progression and hepatocarcinogenesis. Here, we aimed to determine whether serum related the survival time of patients hepatocellular carcinoma (HCC) inhibition production affects rats HCC. Methods: The follow-up data 288 advanced HCC were analyzed. Ten purine metabolites in liver samples diethylnitrosamine (DEN)-induced quantitatively determined by an established UPLC-MS/MS method. On this basis, febuxostat, a specific inhibitor xanthine...
Salt, commonly known as sodium chloride, is an important ingredient that the body requires in relatively minute quantities. However, consuming too much salt can lead to high blood pressure, heart disease and even disruption of circadian rhythms. The biological process rhythm was first studied Drosophila melanogaster well understood. Their locomotor activity gradually increases before light switched on off, a phenomenon called anticipation. In previous study, we showed high-salt diet (HSD)...