A5100350085- Circular RNAs in diseases
- MicroRNA in disease regulation
- RNA modifications and cancer
- Cancer-related molecular mechanisms research
- Biomarkers in Disease Mechanisms
- Epigenetics and DNA Methylation
- Cancer-related gene regulation
- Autophagy in Disease and Therapy
- Immune Cell Function and Interaction
- Cancer Immunotherapy and Biomarkers
- Single-cell and spatial transcriptomics
- Ferroptosis and cancer prognosis
- CRISPR and Genetic Engineering
- Cystic Fibrosis Research Advances
- Bacterial Genetics and Biotechnology
- Endoplasmic Reticulum Stress and Disease
- Cancer Mechanisms and Therapy
- Facial Rejuvenation and Surgery Techniques
- Pancreatic function and diabetes
- Pancreatic and Hepatic Oncology Research
- Kruppel-like factors research
- RNA Research and Splicing
- Dermatologic Treatments and Research
- Immune cells in cancer
- Mycobacterium research and diagnosis
Brigham and Women's Hospital
2023-2025
Shanghai First People's Hospital
2022-2024
Shanghai Jiao Tong University
2023-2024
Anhui University
2024
Harvard University
2023-2024
Massachusetts General Hospital
2023-2024
Nanjing Medical University
2020-2024
Jiangsu Cancer Hospital
2023-2024
Anhui Medical University
2024
Shanghai University of Traditional Chinese Medicine
2024
Redox-cycling compounds, including endogenously produced phenazine antibiotics, induce expression of the efflux pump MexGHI-OpmD in opportunistic pathogen Pseudomonas aeruginosa Previous studies P. virulence, physiology, and biofilm development have focused on blue pyocyanin yellow phenazine-1-carboxylic acid (PCA). In biosynthesis, conversion PCA to is presumed proceed through intermediate 5-methylphenazine-1-carboxylate (5-Me-PCA), a reactive compound that has eluded detection most...
Abstract Background A growing number of studies have focused on investigating circRNAs as crucial regulators in the progression multiple cancer types. Nevertheless, biological effects and underlying mechanisms pancreatic ductal adenocarcinoma (PDAC) remain unclear. Methods Differentially expressed between cancerous tissue adjacent normal tissues were identified by RNA sequencing PDAC. Subsequently, vitro vivo functional experiments performed to investigate roles circNEIL3 PDAC tumour growth...
Abstract Background circular RNAs (circRNAs) have been reported to play crucial roles in the biology of different cancers. However, little is known about function circSTX6 (hsa_circ_0007905) pancreatic ductal adenocarcinoma (PDAC). Methods circSTX6, a circRNA containing exons 4, 5, 6 and 7 STX6 gene, was identified by RNA sequencing detected quantitative reverse transcription PCR (qRT–PCR). The biological assessed vitro vivo. relationship between miR-449b-5p confirmed biotin-coupled capture,...
Abstract CreTA, CRISPR-regulated toxin-antitoxin (TA), safeguards CRISPR-Cas immune systems by inducing cell dormancy/death upon their inactivation. Here, we characterize a bacterial CreTA associating with the I-F in Acinetobacter . CreT is distinct bactericidal small RNA likely targeting several essential molecules that are required to initiate protein synthesis. CreA guides CRISPR effector transcriptionally repress CreT. We further demonstrate proof-of-concept antimicrobial strategy named...
Abstract Protein S -nitrosylation, the redox-based posttranslational modification of a cysteine thiol by attachment nitric oxide (NO) group, is responsible for variety signaling effects. Dysregulation -nitrosylation may be directly linked to cancer apoptotic resistance and therapy outcomes, emphasizing importance in cancer. Peroxiredoxin-2 (Prdx2), an antioxidant enzyme, plays important role protection cells from oxidative radical damage caused hydrogen dioxide (H 2 O ), which potential...
Circular RNAs (circRNAs) are becoming a unique member of non-coding (ncRNAs) with emerging evidence their regulatory roles in various cancers. However, regards to pancreatic ductal adenocarcinoma (PDAC), circRNAs biological functions remain largely unknown and worth investigation for potential therapeutic innovation.In our previous study, next-generation sequencing was used identify differentially expressed 3 pairs PDAC adjacent normal tissues. Further validation circRHOBTB3 expression...
Rationale Respiratory virus-induced inflammation is the leading cause of asthma exacerbation, frequently accompanied by induction interferon-stimulated genes ( ISGs ). How asthma-susceptibility modulate cellular response upon viral infection fine-tuning ISG and subsequent airway in genetically susceptible patients remains largely unknown. Objectives To decipher functions gasdermin B (encoded GSDMB ) respiratory lung inflammation. Methods In two independent cohorts, we analysed expression...
Abstract Upon pathogenic stimulation, activated neutrophils release nuclear DNA into the extracellular environment, forming web‐like structures known as neutrophil traps (NETs), which capture and kill bacteria, fungi, cancer cells. This phenomenon is commonly referred to NETosis. Inspired by this, we introduce a cell surface‐constrained framework nucleic acids (FNATs) with programmable recognition capability cellular behavior modulation. approach facilitates dynamic key chemical signaling...
Rationale: Hyperactivation of Hippo-Yes-associated protein (YAP) signaling pathway governs tumorigenesis gastric cancer (GC). Here we reveal that minichromosome maintenance complex component 6 (MCM6) is a critical transcriptional target YAP in GC. We aim to investigate the function, mechanism action, and clinical implication MCM6 Methods: The downstream targets were screened by RNA sequencing (RNA-seq) microarray, further validated chromatin immunoprecipitation PCR luciferase reporter...
Accurate stroke assessment and consequent favorable clinical outcomes rely on the early identification quantification of aneurysmal subarachnoid hemorrhage (aSAH) in non-contrast computed tomography (NCCT) images. However, hemorrhagic lesions can be complex difficult to distinguish manually. To solve these problems, here we propose a novel Hybrid 2D/3D UNet deep-learning framework for automatic aSAH NCCT We evaluated 1824 consecutive patients admitted with four hospitals China between June...
The rapid development of cosmetic injections has led to an increased incidence nontuberculous mycobacterial (NTM) infection.
From a global perspective, cardiovascular diseases (CVDs), the leading factor accounting for population mortality, and circRNAs, RNA molecules with stable closed-loop structures, have been proven to be closely related. The latent clinical value potential role of circRNAs in CVDs attracting increasing, active research interest, but bibliometric studies this field are still lacking. Thus, study, we conducted analysis by using software such as VOSviewer, CiteSpace, Microsoft Excel, R package...
Abstract Pancreatic cancer (PC) is a malignant tumor with poor prognosis and high mortality. However, the biological role of miR-548t-5p in PC has not been reported. In this study, we found that expression was significantly decreased tissues compared adjacent tissues, low associated behavior. addition, inhibited proliferation, migration, invasion cell lines. Regarding molecular mechanism, luciferase reporter gene, chromatin immunoprecipitation (ChIP), functional recovery assays revealed YY1...
Programmed Cell Death-1/ Death-ligand 1 (PD-1 / PD-L1) inhibitor therapies targeting immunocytes induce persistent tumor remission in various cancers. However, the appropriate biomarkers for therapeutic efficacy of PD-L1 and PD-1 blockade remain elusive.For a comprehensive analysis peri-treatment lymphocyte differentiation, current study, we enrolled 146 non-small cell lung cancer patients who received α-PD-1 exploring peripheral blood differentiation pattern at baseline post-treatment...
Mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) gene lead to (CF), a life-threating autosomal recessive genetic disease. While recently approved Trikafta dramatically ameliorates CF lung diseases, there is still lack of effective medicine treat CF-associated liver disease (CFLD). To address this medical need, we used established rabbit model test if Sotagliflozin, Sodium-Glucose cotransporter 1 and 2 (SGLT1/2) inhibitor drug that diabetes, can be repurposed CFLD....
The transcription factor NRF2 plays a significant role in regulating genes that protect cells from oxidative damage. O-GlcNAc modification, type of posttranslational is crucial for cellular response to stress. Although the involvement both and maintaining redox balance promoting cancer malignancy has been demonstrated, potential mechanisms remain elusive.
Abstract Cancer stem cells (CSCs) are believed to be crucial in the initiation, progression, and recurrence of cancer. CSCs also known more resistant cancer treatments. However, interaction between immune microenvironment is complex not fully understood. In current study we used single cell RNA sequence (scRNA-Seq, public dataset) technology identify characteristic CSCs. We found that lung adenocarcinoma population highly inflammatory remodels tumor by secreting factors, specifically acute...