A5087119578- Endometrial and Cervical Cancer Treatments
- Cervical Cancer and HPV Research
- Global Cancer Incidence and Screening
- Ovarian cancer diagnosis and treatment
- Cardiac, Anesthesia and Surgical Outcomes
- Surgical Simulation and Training
- Uterine Myomas and Treatments
- Genital Health and Disease
- Cancer survivorship and care
- Endometriosis Research and Treatment
- Cancer Genomics and Diagnostics
- Clinical practice guidelines implementation
- Musculoskeletal pain and rehabilitation
- Occupational and environmental lung diseases
- Cancer Cells and Metastasis
- Genetic factors in colorectal cancer
- Hepatitis B Virus Studies
- Patient-Provider Communication in Healthcare
- Maternal and Perinatal Health Interventions
- Reproductive tract infections research
- Lymphatic System and Diseases
- Renal cell carcinoma treatment
- Cancer-related molecular mechanisms research
- Aortic Disease and Treatment Approaches
- Cancer Risks and Factors
University of Leicester
2016-2025
University Hospitals of Leicester NHS Trust
2016-2025
Leicester College
2024
NIHR Leicester Biomedical Research Centre
2023
Centrum voor Gynaecologische Oncologie Amsterdam
2021
Leicester General Hospital
2013-2021
Leicester Royal Infirmary
2015-2021
NHS Greater Glasgow and Clyde
2021
Osaka University
2021
Amsterdam University Medical Centers
2021
CA125 is a high molecular weight glycoprotein, which expressed by large proportion of epithelial ovarian cancers. The sensitivity and specificity are poor there no guidelines produced the Royal College Pathologists or Association Clinical Biochemists to aid clinicians laboratories in its most appropriate use.To identify patient population having measurement determine contribution individual management.A retrospective case note audit looking at patients who had performed between April 2000...
Despite the increasing incidence of endometrial cancer (EC) worldwide and poor overall survival patients who recur, no reliable biomarker exists for detecting monitoring EC recurrence progression during routine follow-up. Circulating tumor DNA (ctDNA) is a sensitive method activity stratifying that are likely to respond therapy. As pilot study, we investigated utility ctDNA in 13 patients, using targeted next-generation sequencing (tNGS) personalized assays. Using tNGS, at least one somatic...
Recommendations are graded as per the Royal College of Obstetricians and Gynaecologists document, Clinical Governance Advice No. 1: Guidance for Development RCOG Green-top Guidelines, available on website at (see Supplementary Tables 1 2 below www.rcog.org.uk/rcog). Definitions certainty evidence based formal GRADE assessment within systematic reviews given in Table 3 [682GRADE Handbook.: Working Group; 2013. Available from:...
// David S. Guttery 1, * , Kevin Blighe Konstantinos Polymeros 2, 3 R. Paul Symonds 1 Salvador Macip and Esther L. Moss 2 Leicester Cancer Research Centre, University of Leicester, Robert Kilpatrick Building, Royal Infirmary, UK Department Gynaecological Oncology, Hospitals NHS Trust, General Hospital, Mechanisms Ageing Lab, Molecular Cell Biology, These authors have contributed equally to this work Correspondence to: Moss, email: em321@leicester.ac.uk Keywords: endometrial cancer;...
Robot-assisted surgery has numerous patient benefits compared to open including smaller incisions, lower risk of infection, less post-operative pain, shorter hospital stays and a quicker return the workforce. As such, it become first-choice surgical modality for several procedures with most common being prostatectomy hysterectomy. However, research identified that perceptions robot-assisted among patients medical staff often do not accurately reflect real-world situation. This study aimed...
The use of robotic-assisted keyhole surgery in gynaecology has expanded recent years owing to technical advances. These include 3D viewing leading improved depth perception, limitation tremor, potential for greater precision and discrimination tissues, a shorter learning curve comfort surgeons compared with conventional open abdominal surgery. Robotic-assisted surgery, improves surgical performance without increasing operating time, minimises blood loss intra- or postoperative complications,...
Real-time quantitative RT–PCR (qRT–PCR) is a powerful technique used for the relative quantification of target genes, using reference (housekeeping) genes normalization to ensure generation accurate and robust data. A systematic examination suitability endogenous gene expression studies in endometrial cancer tissues absent. The aims this study were therefore identify evaluate from thirty-two possible TaqMan® array panel their as an internal control gene. mathematical software packages geNorm...
Introduction. Neuroendocrine carcinoma (NEC) of the cervix is associated with a poor prognosis despite multimodal treatment. The correct diagnosis this tumor type imperative to provide clinicians and patients prognostic information ensure that appropriate treatment provided. Methods. A clinicopathological study was undertaken on all cervical tumors registered as NEC West Midlands Cancer Intelligence Unit between January 1, 1998 December 31, 2009. Of 45 cases diagnosed during period, samples...
Background Human papillomavirus (HPV) is a common sexually transmitted infection that implicated in 99.7% of cervical cancers and several other affect both men women. Despite the role HPV plays an estimated 5% all evolving vaccination testing protecting public against these cancers, preliminary research New Zealand health professionals suggest knowledge about may not be sufficient. Methods A total 230 practice nurses, smear takers clinical laboratory staff who attended range training events...
Objective To examine surgical outcomes and trends in the implementation of minimally invasive surgery (MIS) use for endometrial cancer (EC). Design Retrospective cohort study. Setting English National Health Service hospitals 2011–2017/2018. Population 35 304 patients having a hysterectomy EC identified from Hospital Episode Statistics. Methods Univariate multivariate analyses compared MIS to open (OH) by assessing association between demographic, clinical hospital characteristics using...
<h3>BACKGROUND</h3> A systematic quantitative review was conducted of the evidence relating parental smoking to spirometric indices in children. <h3>METHODS</h3> An electronic search Embase and Medline databases completed April 1997 identified 692 articles from which we included four studies neonates, 42 cross-sectional school aged children (22 were a meta-analysis), six longitudinal lung function development. <h3>RESULTS</h3> In pooled analyses 21 surveys percentage reduction forced...
Primary human papillomavirus (HPV) cervical screening is due to be implemented in England within the next 2 years; however, acceptability of HPV testing as primary test unclear. This study explores women's awareness and attitudes toward testing/screening.Qualitative interviews (semistructured focus group) were conducted with 46 women (aged 25-65 years) from community secondary care settings. Data analyzed by using inductive-framework method.Women unaware that currently includes lacked...
The incorporation of Human papillomavirus (HPV) testing into the English cervical screening programme has been met with fear and anxiety. Healthcare professionals need to be adequately informed about HPV help alleviate patient concerns. aim this study was evaluate training provided practice nurses (PNs) determine their level knowledge.A web-based survey distributed 147 General Practice surgeries in Leicester, Leicestershire Rutland regions, between May July 2015. explored four broad areas;...
There is a lack of public awareness the signs and symptoms uterine cancer, common misconceptions can lead to delays in diagnosis. A three-step co-design principle was undertaken iteratively develop culturally- tailored cancer animated video for Asian Black ethnic minority populations. series focus groups were held with representatives from target populations, survivors healthcare professionals firstly review storyboard script, secondly make adaptions. The content group discussions iterative...