A5075078101- Spinal Fractures and Fixation Techniques
- Scoliosis diagnosis and treatment
- Spine and Intervertebral Disc Pathology
- Pelvic and Acetabular Injuries
- Medical Imaging and Analysis
- Musculoskeletal pain and rehabilitation
- Cervical and Thoracic Myelopathy
- Pregnancy-related medical research
- Anesthesia and Pain Management
- Sarcoma Diagnosis and Treatment
- Orthopaedic implants and arthroplasty
- dental development and anomalies
- Hedgehog Signaling Pathway Studies
- Orthopedic Infections and Treatments
- Bone and Dental Protein Studies
- Hip and Femur Fractures
- Total Knee Arthroplasty Outcomes
- Developmental Biology and Gene Regulation
- Reconstructive Surgery and Microvascular Techniques
- Anorectal Disease Treatments and Outcomes
- Trauma Management and Diagnosis
- Traumatic Ocular and Foreign Body Injuries
- Management of metastatic bone disease
- Spinal Cord Injury Research
- Advanced biosensing and bioanalysis techniques
University of Chicago Medical Center
2020-2025
University of Chicago
2020-2025
American Academy of Orthopaedic Surgeons
2022
Molecular Oncology (United States)
2020-2021
Johns Hopkins University
2012-2020
Johns Hopkins Medicine
2012-2020
Washington University in St. Louis
2019-2020
Johns Hopkins Hospital
2014-2019
University of Fairfax
2012
New York University Langone Orthopedic Hospital
2012
In Brief Study Design. Retrospective review. Objective. To report and analyze the perioperative complications, radiographical results, functional outcomes in elderly patients undergoing pedicle subtraction osteotomy (PSO) and/or vertebral column resection (VCR) procedures for spinal deformity correction. Summary of Background Data. our knowledge, no studies have focused on 3-column osteotomies elderly. Methods. We retrospectively reviewed prospectively collected data 51 consecutive 60 years...
Background: In April 2016, the U.S. Centers for Medicare & Medicaid Services initiated mandatory 90-day bundled payments total hip and knee arthroplasty much of country. Our goal was to determine duration care, charges, readmission rates by discharge disposition region after or arthroplasty. Methods: Using 2008 Provider Analysis Review database 100% sample, we identified patients who had undergone elective primary We collected data on patient age, sex, comorbidities, Census region,...
Mesenchymal stem cells (MSCs) are multipotent progenitors that have the ability to differentiate into multiple lineages, including bone, cartilage, and fat. We previously demonstrated least known bone morphogenetic protein (BMP)9 (also as growth differentiation factor 2) is one of potent osteogenic factors can induce both adipogenic MSCs. Nonetheless, molecular mechanism underlying BMP9 action remains be fully understood. Leptin an adipocyte-derived hormone in direct proportion amount body...
This study reports the surgical and clinical outcomes of spinal tumors managed with total en bloc spondylectomy. The authors searched their prospectively maintained database for patients undergoing spondylectomy between 2001 2013. Ten (9 men, 1 woman; average age, 50.7 years; range, 42-68 years) were identified. obtained demographic information, (estimated blood loss, complications), (recurrence, survival). All had pain classified as American Spinal Injury Association grade E. lesions...
Few studies have examined the postsurgical functional outcomes of adults with spinal deformities, and even fewer focused on results complications among older who undergone primary or revision surgery for deformity. Our goal was to compare patient characteristics, surgical duration hospitalization, radiographic results, complications, between forty years age had deformity those deformity.We retrospectively reviewed cases 167 consecutive patients performed by senior author (K.M.K.) from...
OBJECTIVE Pseudarthrosis is a common complication of long-segment fusions after surgery for correction adult spinal deformity (ASD). Interbody are frequently used at the caudal levels constructs as adjuncts anterior column support. There paucity literature comparing rod fracture rates (proxy pseudarthrosis) in patients undergoing transforaminal lumbar interbody fusion (TLIF) versus (ALIF) long construct. In this study authors sought to compare ASD with TLIF ALIF constructs. METHODS We...
A 60-year-old female sustained a left unilateral C3-4 facet dislocation and underwent urgent open reduction posterior instrumentation. The patient subsequently developed delayed onset right upper extremity weakness affecting the C5 myotome, prompting diagnosis of post-operative palsy (C5P). With conservative management, had complete neurologic recovery in eight months. Surgeons must be aware development C5P whenever operating on cervical spine, regardless operative level or procedure...
Study Design: Systematic literature review. Objective: To summarize the demographics, diagnosis, clinical course, management, and outcomes for implant migration after anterior cervical spine surgery. Summary of Background Data: Implant following surgery is a rare event that may predispose patients to high morbidity due proximity implants critical structures. Due infrequency this complication, most on topic described in case reports or series. Methods: We screened PubMed database relevant...
Under the Physician Payments Sunshine Act, "payments or transfers of value" by biomedical companies to physicians must be disclosed through Open Program. Designed provide transparency financial transactions between medication and device manufacturers health care providers, Program shows relationships industry providers. Awareness this program is crucial because its interpretation misinterpretation patients, physicians, general public can affect patient care, clinical practice, research. This...
RNA interference (RNAi) is mediated by an ∼21-nt double-stranded small interfering (siRNA) and shows great promise in delineating gene functions developing therapeutics for human diseases. However, effective silencing usually requires the delivery of multiple siRNAs a given gene, which often technically challenging time-consuming. In this study, exploiting type IIS restriction endonuclease-based synthetic biology methodology, we developed fast assembly multiplex (FAMSi) system. our...
OBJECTIVE Recommendations for the surgical treatment of isolated lumbar spinal stenosis (LSS) (i.e., in absence concomitant scoliosis or spondylolisthesis) are unclear. The aims this study were to investigate trends LSS US adults and determine implications outcomes. METHODS authors analyzed inpatient outpatient claims from Truven Health Analytics MarketScan Commercial Claims Encounters Database 20,279 patients aged 40-64 years who underwent surgery between 2010 2014. Only with continuous...
Plasmid DNA (pDNA) isolation from bacterial cells is one of the most common and critical steps in molecular cloning biomedical research. Almost all pDNA purification involves disruption bacteria, removal membrane lipids, proteins genomic DNA, bulk lysate, concentration for downstream applications. While many liquid-phase solid-phase methods are used, final preparations usually contaminated with varied degrees host RNA, which cannot be completely digested by RNase A. To develop a simple,...
In this study, the authors compared outcomes and complications in patients with without rheumatoid arthritis (RA) who underwent surgery for spinal deformity.The searched Johns Hopkins University database RA (Group RA) NoRA) long fusion scoliosis by 3 surgeons at 1 institution from 2000 through 2012. Groups NoRA each had 14 were well matched regard to sex (13 women/1 man 12 women/2 men, respectively), age (mean 66.3 years [range 40.5-81.9 years] 67.6 51-81 years]), follow-up duration 35.4...
Abstract Teeth arise from the tooth germ through sequential and reciprocal interactions between immature epithelium mesenchyme during development. However, detailed mechanism underlying development mesenchymal cells (TGMCs) remains to be fully understood. Here, we investigate role of Wnt/β‐catenin signalling in BMP9‐induced osteogenic/odontogenic differentiation TGMCs. We first established reversibly immortalized TGMCs (iTGMCs) derived young mouse mandibular molar germs using a retroviral...
Pelvic insufficiency fractures are fairly common in elderly patients and can be a source of major functional impairment, particularly when they involve the ilium. Early rehabilitation with adequate pain relief has been traditional method treatment. The recently developed S2 alar iliac technique involves placing pelvic fixation into ilium through pathway from sacral ala. bony channel between second dorsal foramen anterior inferior spine is used to provide rigid sacropelvic for adult pediatric...
In this study, the authors' goal was to determine intra- and interobserver reliability of a new classification system that allows description all possible constructs used across three-column osteotomies (3COs) in terms rod configuration density.
Systematic review and meta-analysis.Indications for surgical decompression of gunshot wounds to the lumbosacral spine are controversial based on limited data.A systematic literature was conducted identify studies that directly compare neurologic outcomes following operative non-operative management spine. Studies were evaluated degree improvement, complications, antibiotic usage. An odds ratio 95% confidence interval calculated dichotomous which then pooled by random-effects model...