A5100425530- Cholinesterase and Neurodegenerative Diseases
- Natural product bioactivities and synthesis
- Computational Drug Discovery Methods
- Phytochemistry and Biological Activities
- Ga2O3 and related materials
- ZnO doping and properties
- Synthesis and biological activity
- Medicinal Plants and Neuroprotection
- Chemical synthesis and alkaloids
- Protein Tyrosine Phosphatases
- Traditional and Medicinal Uses of Annonaceae
- Phytochemical compounds biological activities
- Phytochemicals and Antioxidant Activities
- Ubiquitin and proteasome pathways
- Advanced Photocatalysis Techniques
- Treatment of Major Depression
- Alzheimer's disease research and treatments
- Lung Cancer Research Studies
- Functional Brain Connectivity Studies
- Pharmacological Effects of Natural Compounds
- Bioactive Compounds and Antitumor Agents
- Radiomics and Machine Learning in Medical Imaging
- Cancer Treatment and Pharmacology
- Synthetic Organic Chemistry Methods
- Curcumin's Biomedical Applications
Chinese Academy of Sciences
2009-2025
Suzhou Institute of Nano-tech and Nano-bionics
2021-2025
Nanjing University of Chinese Medicine
2025
Second Xiangya Hospital of Central South University
2023-2024
Sun Yat-sen University
2024
Sun Yat-sen University Cancer Center
2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2008-2024
Central South University
2023-2024
Shenzhen Children's Hospital
2024
Children's Hospital of Chongqing Medical University
2024
Immunotherapy using checkpoint inhibitors, especially PD-1/PD-L1 has now evolved into the most promising therapy for cancer patients. However, of these inhibitors are monoclonal antibodies, and their large size may limit tumor penetration, leading to suboptimal efficacy. As a result, there been growing interest in developing low-molecular-weight inhibitors.We developed novel biopanning strategy discover small peptide-based anti-PD-L1 inhibitors. The affinity specificity peptides PD-L1 were...
Based on a reverse micelle strategy, we successfully synthesized new magnetic silica nanoparticles functionalized with bulky N-heterocyclic carbene (N,N′-bis(2,6-diisopropylphenyl)imidazol-2-ylidene, denoted as IPr) precursor through the co-condensation of IPr-bridged organosilane and tetraalkoxysilane in one-pot reaction. TEM SEM investigations revealed that particle sizes materials were uniformly distributed range 15–30 nm, could be tuned by varying amount siliceous precursors. FT-IR XPS...
Breast cancers (BrCas) that overexpress oncogenic tyrosine kinase receptor HER2 are treated with HER2-targeting antibodies (such as trastuzumab) or small-molecule inhibitors lapatinib). However, most patients metastatic + BrCa have intrinsic resistance and nearly all eventually become resistant to therapy. Resistance drugs frequently involves transcriptional reprogramming associated constitutive activation of different signaling pathways. We investigated the role CDK8/19 Mediator kinase, a...
A matrix-assisted laser desorption/ionization Fourier transform mass spectrometry (MALDI-FTMS)-based assay was developed for kinetic measurements and inhibitor screening of acetylcholinesterase. Here, FTMS coupled to MALDI applied quantitative analysis choline using the ratio choline/acetylcholine without use additional internal standard, which simplified experiment. The Michaelis constant (K(m)) acetylcholinesterase (AChE) determined be 73.9 micromol L(-1) by this approach. For Huperzine A,...
Insulin like growth factor II receptor (IGFIIR) is a transmembrane protein overexpressed in activated hepatic stellate cells (HSCs), which are the major target for treatment of liver fibrosis.In this study, we aim to discover an IGFIIR-specific aptamer that can be potentially used as targeting ligand and diagnosis fibrosis.Systematic evolution ligands by exponential enrichment (SELEX) was conducted on recombinant human IGFIIR identify aptamers.The binding affinity specificity discovered...
Senexins are potent and selective quinazoline inhibitors of CDK8/19 Mediator kinases. To improve their potency metabolic stability, quinoline-based derivatives were designed through a structure-guided strategy based on the simulated drug–target docking model Senexin A B. library quinoline-Senexin was synthesized to explore structure–activity relationship (SAR). An optimized compound 20a (Senexin C) exhibits inhibitory activity with high selectivity. C is more metabolically stable provides...
The acetyltransferase inhibitor garcinol, a polyisoprenylated benzophenone, is extracted from the rind of fruit Garcinia indica, plant found extensively in tropical regions. Anti-cancer activity has been suggested but there no report on its action via inhibiting acetylation against cell proliferation, cycle progression, and apoptosis-inhibtion induced by estradiol (<TEX>$E_2$</TEX>) human breast cancer MCF-7 cells. main purposes this study were to investigate effects garcinol progression...
Four new lycodine-type alkaloids, namely 16-hydroxyhuperzine B (1), N-methyl-11-acetoxyhuperzine (2), 8,15-dihydrolycoparin A (3) and (7S,12S,13R)-huperzine D-16-O-β-d-glucopyranoside (4), along with ten known analogues 5-14, were isolated from the whole plant of Lycopodiastrum casuarinoides. The structures compounds elucidated by means spectroscopic techniques (IR, MS, NMR, CD) chemical methods. Compounds 1 2 possessed four connected six-membered rings, while 3 4 piperidine ring cleavage...