A5027734329- Drug-Induced Adverse Reactions
- Synthesis and Characterization of Heterocyclic Compounds
- X-ray Diffraction in Crystallography
- Crystallization and Solubility Studies
- Multicomponent Synthesis of Heterocycles
- Pneumocystis jirovecii pneumonia detection and treatment
- Organophosphorus compounds synthesis
- Immune Cell Function and Interaction
- Asthma and respiratory diseases
- Pharmacogenetics and Drug Metabolism
- Chemical Reaction Mechanisms
- Crystallography and molecular interactions
- Photosynthetic Processes and Mechanisms
- Glycosylation and Glycoproteins Research
- Metal and Thin Film Mechanics
- Synthesis and Reactions of Organic Compounds
- Mast cells and histamine
- Carbohydrate Chemistry and Synthesis
- Extracellular vesicles in disease
- Insect Utilization and Effects
- Computational Drug Discovery Methods
- Flame retardant materials and properties
- Synthesis and biological activity
- Contact Dermatitis and Allergies
- Metabolomics and Mass Spectrometry Studies
Instituto Politécnico Nacional
2014-2023
University of Liverpool
2009-2012
Medical Research Council
2010
The clustered regularly interspaced short palindromic repeat/CRISPR-associated protein 9 (CRISPR/Cas9) technology is a versatile and useful tool to perform genome editing in different organisms ranging from bacteria yeast plants mammalian cells. For couple of years, it was believed that the system inefficient toxic alga
Recognition of drugs by immune cells is usually explained the hapten model, which states that endogenous metabolites bind irreversibly to protein stimulate cells. Synthetic interact directly with protein-generating antigenic determinants for T cells; however, experimental evidence relating intracellular metabolism in and generation physiologically relevant Ags functional responses lacking. The aim this study was develop an integrated approach using animal human systems characterize...
Abstract An emerging clinical issue associated with immune-oncology agents is the collateral effects on tolerability of concomitant medications. One report this phenomenon was increased incidence hypersensitivity reactions observed in patients receiving concurrent immune checkpoint inhibitors (ICIs) and sulfasalazine (SLZ). Thus, aim study to characterize T cells involved pathogenesis such reactions, recapitulate inhibitory blockade de-novo priming responses compounds within vitro platforms....
Exposure to sulfamethoxazole (SMX) is associated with T-cell-mediated hypersensitivity reactions in human patients. T-cells can be stimulated by the putative metabolite nitroso SMX, which binds irreversibly protein. The hydroxylamine and derivatives of three arylamine benzenesulfonamides, namely, sulfamethozaxole, sulfadiazine, sulfapyridine, were synthesized, their T-cell stimulatory capacity mouse was explored. Nitroso synthesized a three-step procedure involving formation nitro...
This study evaluates the tribological behavior of borided AISI 316L steel. The treatment time was set to 2, 4, and 6 h at temperatures 850, 900, 950°C for each duration. morphology microstructure boride layers were analyzed by scanning electron microscopy (SEM) X ray diffraction (XRD), respectively. mechanical properties evaluated an instrumented nanoindentation test. behaviors using a sand/rubber apparatus following ASTM G-65 standard. friction coefficient estimated means pin-on-disk...
Intramolecular hydrogen bond (HB) formation was analyzed in the model compounds N-(2-benzoylphenyl)acetamide, N-(2-benzoylphenyl)oxalamate and N1,N2-bis(2-benzoylphenyl)oxalamide. The of three-center bonds oxalyl derivatives demonstrated solid state by X-ray diffraction analysis geometric parameters associated with molecular structures. solvent effect on chemical shift H6 [δH6(DMSO-d6)–δH6(CDCl3)] Δδ(ΝΗ)/ΔT measurements, DMSO-d6 as solvent, have been used to establish energetics...
Dysregulation in the expression of microRNAs (miRNAs), single-stranded RNAs which regulate gene expression, has been associated with diseases such as Stevens-Johnson syndrome (SJS)/toxic epidermal necrolysis (TEN), although their cellular origin not explored. Thus, focus this work was to study patterns reported miRNAs involved T-cell activation following drug-specific stimulation peripheral blood mononuclear cells (PBMCs) and CD4+ clones (TCC) from patients different cutaneous manifestations...
This investigation describes the formation of crystalline nanotubes titanium oxide on surface a Ti-6Al-4V alloy and its biological evaluation. The was performed by anodic oxidation technique with constant work potential 60 V but different anodizing times 10, 20, 30, 40, 50, min used to evaluate their effects characteristics activity. A mixture ethylene glycol, water, ammonium fluoride (NH4F) as electrolytic fluid. Scanning electron microscopy (SEM) X-ray diffraction (XRD) were applied...
T-cells are activated by different mechanisms in the presence of drugs, metabolites or haptens, and they release several molecules that can be used diagnosis drug hypersensitivity.
We present a multicomponent reaction strategy to synthesize (dihydro-1H-benzo[d]imidazole)phosphonate family of compounds, using benzimidazoles, diethyl chlorophosphate and aliphatic amines as starting reactants. Giving its simplicity, our procedure involves times only few hours avoid the usage any catalyst agent. All newly synthesized compounds were characterized by Nuclear Magnetic Resonance spectroscopy (1H, 13C 31P) mass spectrometry DART method.
Cutaneous drug-induced reactions are immune-mediated responses that can lead to life-threatening diseases such as drug reaction with eosinophilia and systemic symptoms (DRESS), Stevens–Johnson syndrome, toxic epidermal necrolysis, collectively known severe cutaneous adverse (SCARs). Unfortunately, they cannot be predicted during development, and, at present, a prognostic biomarker is not available nor validated in vitro assays for diagnosis. Thus, by using proteomic microarray miRNA...
We present a new single-step multicomponent reaction strategy for the synthesis of symmetric and (novel) asymmetric bisphosphoramidate bisphosphoramidothioate derivatives. Reactions proceed under routine experimental conditions, do not require aid any catalyst, provide moderate yields after short time. synthesized 18 different compounds, 10 them first The cytotoxic activity our adducts was assessed by measuring their inhibitory capacity (IC50) against two cell lines, A549 (lung cancer cells)...
The human gut is home to a complex array of microorganisms interacting with the host and each other, forming community known as microbiome. This has been linked health disease, but understanding underlying interactions still challenging for researchers. Standard studies typically use high-throughput sequencing analyze microbiome distribution in patient samples. Recent advancements meta-omic data analysis have enabled computational modeling strategies integrate this information into an silico...
A novel three-component one-pot reaction procedure was designed for the synthesis of symmetric and asymmetric bisphosphoramidate derivatives. Our key reactants were a set four aliphatic diamines, which individually react with two different phosphoryl chloride derivatives (N,N,N′,N′-tetramethylphosphorodiamide diphenyl chloride). total 10 products, six them none reported before, synthetized. The proposed experimental does not involve any catalyst proceeds under routine conditions (room...
A detailed structural analysis of the benzimidazole nitroarenes 1-(4-nitrophenyl)-1 H -1,3-benzimidazole, C 13 9 N 3 O 2 , (I), 1-(4-nitrophenyl)-2-phenyl-1 19 (II), and 2-(3-methylphenyl)-1-(4-nitrophenyl)-1 20 15 (III), has been performed. They are nonplanar structures whose crystal arrangement is governed by sp —H... ( = NO py π) hydrogen bonding. The inherent complexity supramolecular arrangements compounds (I) Z ′ 2) (II) 4) into tapes, helices sheets result additional participation...
A fast, safe and accessible multicomponent reaction procedure is reported for the synthesis of symmetric nonsymmetric benzyl-bisphosphoramidate derivatives. Our key reagents were 1,3-phenylenedimethanamine 3 conjointly with five different phosphorous chlorides, O, O′-diethyl chlorothiophosphate 1, diphenyl phosphoryl chloride 2, diethyl chlorophosphate 5, N, N ′, N′-tetramethylphosphorodiamidic 7 O′-dimethyl 9. total seven products obtained, them none before. As far as we know, our work...