A5022481252- SARS-CoV-2 and COVID-19 Research
- COVID-19 epidemiological studies
- SARS-CoV-2 detection and testing
- COVID-19 Clinical Research Studies
- Antibiotic Resistance in Bacteria
- COVID-19 and Mental Health
- Long-Term Effects of COVID-19
- Viral gastroenteritis research and epidemiology
- Gut microbiota and health
- Bacterial Identification and Susceptibility Testing
- Animal Virus Infections Studies
- Neuropeptides and Animal Physiology
- Substance Abuse Treatment and Outcomes
- Pain Mechanisms and Treatments
- Olfactory and Sensory Function Studies
- Mobile Health and mHealth Applications
- Pain Management and Opioid Use
- Alcohol Consumption and Health Effects
- vaccines and immunoinformatics approaches
- Respiratory viral infections research
- Immunotherapy and Immune Responses
- Health, Medicine and Society
- Viral Infections and Outbreaks Research
- Plant Pathogenic Bacteria Studies
- Health Systems, Economic Evaluations, Quality of Life
Ochsner Medical Center
2020-2023
University of New Orleans
2021-2023
Citizen (Japan)
2023
Children's Hospital of Philadelphia
2022
Fenway Health
2022
Orlando Health
2022
Duke University
2022
Vanderbilt University Medical Center
2022
Intermountain Healthcare
2022
University of Kansas
2022
The COVID-19 pandemic has magnified longstanding health care and social inequities, resulting in disproportionately high COVID-19-associated illness death among members of racial ethnic minority groups (1). Equitable use effective medications (2) could reduce disparities these severe outcomes (3). Monoclonal antibody (mAb) therapies against SARS-CoV-2, the virus that causes COVID-19, initially received Emergency Use Authorization (EUA) from Food Drug Administration (FDA) November 2020. mAbs...
This cohort study examines time trends in officially reported SARS-CoV-2 case counts and unreported home test positivity.
Long-term immunity against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) requires the identification of T-cell epitopes affecting host immunogenicity. In this computational study, we explored CD8 + epitope diversity estimated in 27 most common HLA-A and HLA-B alleles, representing United States population. Analysis 16 SARS-CoV-2 variants [B.1, Alpha (B.1.1.7), five Delta (AY.100, AY.25, AY.3, AY.3.1, AY.44), nine Omicron (BA.1, BA.1.1, BA.2, BA.4, BA.5, BQ.1, BQ.1.1, XBB.1,...
Numerous studies have identified the proinflammatory, pronociceptive effects of morphine which ultimately exacerbate pain. Our novel endomorphin analog ZH853 does not produce proinflammatory on its own and gives potent, long-lasting analgesia. This study investigates whether ZH853's lack interaction with neuroimmune system reduces risk prolonged Adult male Sprague-Dawley rats were subjected to one two treatment paradigms. Either (1) chronic pain followed by morphine, or vehicle, (2) drug...
Abstract By using paired molecular and antibody testing for severe acute respiratory syndrome coronavirus 2 infection, we determined point prevalence seroprevalence in Louisiana, USA, during the second phase of reopening. Infections were highly variable by race ethnicity, work environment, ZIP code. Census-weighted was 3.6%, 3.0%.
Using a novel recruitment method and paired molecular antibody testing for severe acute respiratory syndrome coronavirus 2 infection, we determined seroprevalence in racially diverse municipality Louisiana, USA. Infections were highly variable by ZIP code differed race/ethnicity. Overall census-weighted was 6.9%, the calculated infection fatality ratio 1.63%.
ABSTRACT Despite the potential relevance to clinical outcome, intra-host dynamics of SARS-CoV-2 are unclear. Here, we quantify and characterize variation in raw sequence data uploaded SRA as 14 April 2020, compare results between two sequencing methods (amplicon RNA-Seq). Raw fastq files were quality filtered trimmed using Trimmomatic, mapped WuhanHu1 reference genome Bowtie2, variants called with bcftools mpileup . To ensure sufficient coverage, only included samples 10X coverage for...
ABSTRACT Eravacycline is a synthetic fluorocycline approved by the U.S. Food and Drug Administration in 2018. This study aimed to describe clinical microbiological outcomes addition associated adverse effects of eravacycline used hospitals. Real-world, observational involving patients receiving ≥72 h at 19 medical centers located all 5 regions United States between October 2018 August 2022. The primary outcome was success, defined as survival absence recurrence 30 days from end therapy...
Whole genome sequencing (WGS) of bacterial isolates can be used to identify antimicrobial resistance (AMR) genes. Previous studies have shown that genotype-based AMR has variable accuracy for predicting carbapenem in carbapenem-resistant Enterobacterales (CRE); however, the majority these short-read platforms (e.g. Illumina) generate sequence data. In this study, our objective was determine whether Oxford Nanopore Technologies (ONT) long-read WGS would improve detection genes with respect...
Viral infections are known to modulate the upper respiratory tract microbiome, but few studies have addressed differences in nasopharyngeal microbiome following SARS-CoV-2 infection. Using swab medical waste samples from 79 confirmed positive and 20 negative patients, we assessed composition with metagenomic sequencing. COVID-19 status breathing assistive device use was associated beta diversity, principal component analyses, community abundance of several species. Serratia more frequently...
ObjectiveWhile many seroprevalence studies of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) have been performed, few are demographically representative. This investigation focused on defining the nature and frequency symptomatic asymptomatic SARS-CoV-2 infection in a representative, cross-sectional sample communities Louisiana, USA.MethodsA 4778 adults from New Orleans Baton Rouge, Louisiana were given survey symptoms co-morbidities, nasopharyngeal swab to test for active...
Objective Determine whether an individual is at greater risk of severe acute respiratory distress syndrome coronavirus 2 (SARS-CoV-2) infection because their community or factors. Study design and setting 4,752 records from two large prevalence studies in New Orleans Baton Rouge, Louisiana were used to assess zip code tabulation areas (ZCTA)-level area deprivation index (ADI) factors accounted for infection. Logistic regression models assessed associations individual-level demographic...
<h3></h3> <b>Background:</b> In the state of Louisiana, prevalence Alzheimer disease (AD) is projected to increase 26.4% by 2025 because rapidly increasing geriatric population. While significant research available on risk factors for developing AD, less data are regarding AD progression and rate change among patients with disease. To date, no has established baseline cognitive decline residing in New Orleans, Louisiana. <b>Methods:</b> We evaluated 100 Ochsner Health system from September...
Abstract The emergence of the early COVID-19 epidemic in United States (U.S.) went largely undetected, due to a lack adequate testing and mitigation efforts. city New Orleans, Louisiana experienced one earliest fastest accelerating outbreaks, coinciding with annual Mardi Gras festival, which ahead without precautions. To gain insight into SARS-CoV-2 U.S. how large, crowded events may have accelerated transmission, we sequenced genomes during first wave Louisiana. We show that initially had...
Abstract Using a novel recruitment method to reduce selection bias with paired molecular and antibody testing for SARS-CoV-2 infection, we determined point prevalence in racially diverse municipality. Infections were highly variable by ZIP differed race. Overall census-weighted was 7.8% the calculated infection fatality rate 1.63%.
Abstract Using paired molecular and antibody testing for SARS-CoV-2 infection, we determined point prevalence seroprevalence in a municipality Louisiana, USA during the second phase of reopening. Infections were highly variable by race, work environment, ZIP code. Census-weighted 3.6% 3.0%, respectively.
Identification of epitopes targeted following virus infection or vaccination can guide vaccine design and development therapeutic interventions targeting functional sites, but be laborious. Herein, we employed peptide microarrays to map linear (LPEs) recognized SARS-CoV-2 vaccination. LPEs detected by nonhuman primate (NHP) patient IgMs after extensively overlapped, localized functionally important regions, aligned with reported neutralizing antibody binding sites. Similar LPE overlap...
We investigated 51 gram-negative carbapenem-resistant Enterobacterales (CRE) isolates collected from 22 patients over a five-year period six health care institutions in the Ochsner Health network southeast Louisiana. Short genomic reads were generated using Illumina sequencing and assembled for each isolate. Isolates classified as Enterobacter spp. (n=20), Klebsiella (n=30), Escherichia coli (n=1) grouped into 19 different multi-locus sequence types (MLST). Species patient-specific core...
Background: Individuals infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) who do not report symptoms throughout the course of infection (asymptomatic) or those are asymptomatic when they first contract virus (presymptomatic) a major public health concern. However, few prevalence studies to date have targeted question frequency within community. Methods: A stratified, random sample subjects were sent testing sites complete verbal consent, survey, nasopharyngeal swab,...
Abstract Background Laboratory and physical metric data were available from participants of Alcohol Free for 40 (AFF40), a 40-day alcohol abstinence program in Louisiana. This study was performed to determine whether biometric changes detectable after days. Materials Methods retrospective review three cohorts AFF40 participants. Participant pre- post-program analyzed (n=113, 2019; n=105, 2020; n=344, 2021). The intervention self-directed, with social support. Changes liver enzymes,...
Abstract Background Individuals infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) who do not report symptoms throughout the course of infection (asymptomatic) or those are asymptomatic when they first contract virus (presymptomatic) a major public health concern. However, few prevalence studies to date have targeted question frequency within community. Methods A stratified, random sample subjects were sent testing sites complete verbal consent, survey, nasopharyngeal...