A5070881875- Bacteriophages and microbial interactions
- Bacterial biofilms and quorum sensing
- Antibiotic Resistance in Bacteria
- SARS-CoV-2 and COVID-19 Research
- SARS-CoV-2 detection and testing
- Viral Infections and Vectors
- Bacillus and Francisella bacterial research
- Complement system in diseases
- Toxin Mechanisms and Immunotoxins
- Mosquito-borne diseases and control
- Microbial Community Ecology and Physiology
- Polymer Surface Interaction Studies
- Bacterial Genetics and Biotechnology
- Plant Virus Research Studies
- Microbial infections and disease research
- Transgenic Plants and Applications
- Vector-Borne Animal Diseases
- Vibrio bacteria research studies
- Viral gastroenteritis research and epidemiology
- Aquaculture disease management and microbiota
- Enterobacteriaceae and Cronobacter Research
- CRISPR and Genetic Engineering
- COVID-19 diagnosis using AI
- Vector-borne infectious diseases
- Animal Virus Infections Studies
Astrakhan State Medical University
2010-2025
Ministry of Health of the Russian Federation
2019-2024
We have developed a phagebiotic composition using 8 virulent bacteriophages (2 strains of each species) which are able to lyse Acinetobacter baumannii, Klebsiella pneumoniae, Pseudomonas aeruginosa and Staphylococcus aureus. The unique character the is ensured by particular properties bacteriophage comprising preparation, including their range lytic activity toward specific bacterial pathogens, morphology plaques, cycle development, restriction profile DNAs, specificity genomes (based on...
Surfaces of implanted medical devices are highly susceptible to biofilm formation. Bacteria in biofilms embedded a self-produced extracellular matrix that inhibits the penetration antibiotics and significantly contributes mechanical stability colonizing community which leads an increase morbidity mortality rate clinical settings. Therefore, new antibiofilm approaches substances urgently needed. In this paper, we test efficacy broad-range recombinant endolysin coliphage LysECD7 against...
Isolated bacteria, their morphological, biochemical, and genetic properties are, to this day, the main object of research since isolation a pure culture pathogen by R. Koch his formulation postulates reflecting role microorganism in development infectious diseases. The pharmacokinetic pharmacodynamic compounds with potential antibacterial activity are also studied relation planktonic, free cells. In recent years, as knowledge accumulates new infections conditions involving specially...
Healthcare-associated infections (HAIs) are a global medical and socioeconomic problem. Nosocomial occupy one of the leading places among causes death in Russian Federation. About 60–70% all nosocomial associated with use implants various profiles. Pseudomonas aeruginosa , types streptococci, staphylococci, Escherichia coli enterococci ( Enterococcus faecalis ), Klebsiella pneumoniae Proteus mirabilis representatives genus Acinetobacter highly likely to be found biofilms supplies. A...
Staphylococcus aureus has a high level of antibiotic resistance and is common cause nosocomial infections, which primarily requires development new therapeutic strategies. Aim the study was to investigate spectrum S. isolates for further isolation virulent bacteriophages. Material methods . The used samples clinical material obtained on basis City Clinical Hospital No. 3 named after S.M. Kirov (Astrakhan). Bacterial strains isolated from patients were identified morphological, cultural,...
One of the main biological characteristics SARS-CoV-2 is its remarkable ability to adapt new environmental conditions. Accelerated evolution COVID-19 pathogen complicates anti-epidemic measures, including need update antigenic composition vaccines and maintain current vaccination prognosis infection course, reduces efficacy drugs based on monoclonal antibodies specific antiviral inhibitors. Under these conditions, search for approaches monitoring clinically epidemiologically significant...
The globalization of the problem formation bacterial strains poly- and pan-resistant to known antimicrobial drugs creates high risks in healthcare sector. threat a return «pre-antibiotic» era dictates need search for alternative forms antibacterial therapy. Phage therapy, based on use natural, widely distributed environment, accessible agent, is again becoming relevant. article highlights mechanisms antiviral protection prokaryotes at various stages interaction between virus target cell....
<h3></h3> Несколько совещаний рабочей группы ФЛМ по лабораторной диагностике COVID-19 были посвящены обсуждению возможностей и ограничений объединения (пулирования) проб, уже в течение длительного времени применяемого службе крови активно обсуждаемого последнее время зарубежной печати рекомендациях ВОЗ качестве одного из способов увеличения производительности снижения затрат при исследованиях выявлению SARS-CoV-2. Более того, условиях имевшей место острой нехватки выполнить требуемый объем...
The article describes immunoassay methods of determining the functional activity components C3 and C9 C1 inhibitor for diagnostic prognostic purposes in treatment patients. these components, as well amount blood serum children aged 6 months to 18 years suffering from atopic dermatitis have been analyzed before after determine involvement complement system pathogenesis this disease. developed enzyme determination shown high sensitivity reliability. component involved membrane attack was...
Antimicrobial resistance is considered by WHO as one of the most important threats to public health in twenty-first century. According forecasts, 2025, many first-line antimicrobials will lose their effectiveness and «post-antibiotic era» begin. Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa, Enterobacter spp. representatives genus Mycobacterium are classified American Society Infectious Diseases microorganisms that play a...
The paper presents the results of a clinical observation and complex examination 48 patients with Q-fever, blood samples from 20 them were tested for lysozyme, complement, circulating immune complexes (CIC). swing disease was characterized by maximum manifestations disease. Early reconvalescence marked decrement in symptoms gradual recovery body's impaired functions. study indicated relationship between level nonspecific resistance factors stage pathologic process. showed an increase amount...