Е. А. Воропаева
A5034547682- Pneumonia and Respiratory Infections
- Bacterial Infections and Vaccines
- Urinary Tract Infections Management
- Respiratory viral infections research
- Pediatric health and respiratory diseases
- Reproductive tract infections research
- Reproductive System and Pregnancy
- Respiratory and Cough-Related Research
- Cytomegalovirus and herpesvirus research
- HIV, TB, and STIs Epidemiology
- Probiotics and Fermented Foods
- Herpesvirus Infections and Treatments
- Antibiotic Resistance in Bacteria
- Antibiotics Pharmacokinetics and Efficacy
- Pelvic floor disorders treatments
- Salivary Gland Disorders and Functions
- Dermatology and Skin Diseases
- Zoonotic diseases and public health
- Preterm Birth and Chorioamnionitis
- Toxoplasma gondii Research Studies
- Lipoproteins and Cardiovascular Health
- thermodynamics and calorimetric analyses
- Medical and Agricultural Research Studies
- Diabetes and associated disorders
- Psoriasis: Treatment and Pathogenesis
Gabrichevsky Institute of Epidemiology and Microbiology
2006-2024
Pirogov Russian National Research Medical University
2023
Federal Service for Surveillance on Consumer Rights Protection and Human Wellbeing
2019-2022
University of Duisburg-Essen
2007
Invasive pneumococcal disease remains an important health priority owing to increasing incidence caused by pneumococci expressing non-vaccine serotypes. We previously defined 621 Global Pneumococcal Sequence Clusters (GPSCs) analysing 20 027 isolates collected worldwide and from published genomic data. In this study, we aimed investigate the lineages behind predominant serotypes, mechanism of serotype replacement in disease, as well major contributing invasive post-vaccine era their...
Abstract Streptococcus pneumoniae is a leading cause of pneumonia and meningitis worldwide. Many different serotypes co-circulate endemically in any one location 1,2 . The extent mechanisms spread vaccine-driven changes fitness antimicrobial resistance remain largely unquantified. Here using geolocated genome sequences from South Africa ( n = 6,910, collected 2000 to 2014), we developed models reconstruct spread, pairing detailed human mobility data genomic data. Separately, estimated the...
The World Health Organization (WHO) coordinates the Global Invasive Bacterial Vaccine-Preventable Diseases (IB-VPD) Surveillance Network to support vaccine introduction decisions and use. network was established strengthen surveillance laboratory confirmation of meningitis caused by Streptococcus pneumoniae, Haemophilus influenzae, Neisseria meningitidis.
Multidrug-resistant Streptococcus pneumoniae emerge through the modification of core genome loci by interspecies homologous recombinations, and acquisition gene cassettes. Both occurred in otherwise contrasting histories antibiotic-resistant S. lineages PMEN3 PMEN9. A single clade spread globally, evading vaccine-induced immunity frequent serotype switching, whereas locally circulating PMEN9 clades independently gained resistance. repeatedly integrated Tn 916 -type 1207.1 elements,...
Pneumococcal disease outbreaks of vaccine preventable serotype 4 sequence type (ST)801 in shipyards have been reported several countries. We aimed to use genomics establish any international links between them.Sequence data from ST801-related outbreak isolates Norway (n = 17), Finland 11) and Northern Ireland 2) were combined with invasive pneumococcal surveillance the respective countries, genomes an collection 41 > 40,000), totalling 106 genomes. Raw mapped recombination excluded before...
Background. Ezetimibe has shown efficacy in the therapy of hypercholesterolemia renal transplant patients. This is first study investigating effect ezetimibe on function kidney recipients.
Abstract Objectives We reported tet(S/M) in Streptococcus pneumoniae and investigated its temporal spread relation to nationwide clinical interventions. Methods whole-genome sequenced 12 254 pneumococcal isolates from 29 countries on an Illumina HiSeq sequencer. Serotype, multilocus ST antibiotic resistance were inferred genomes. An SNP tree was built using Gubbins. Temporal reconstructed a birth–death model. Results identified 131 none carried other known tet genes. Tetracycline...
Invasive pneumococcal disease remains one of the leading causes morbidity and mortality worldwide. In Russia, 13- valent conjugate vaccine (PCV13) was introduced into childhood immunization programme nationwide in 2014. As part Global Pneumococcal Sequencing Project (GPS), we used genome data to characterize 179 isolates collected from Russia 2011-2018 investigate circulating strains using a standardized genomic definition lineages (global sequence clusters, GPSCs), prevalent serotypes...
According to Russian classification, bacterial vaginosis (BV) and nonspecific vaginitis (NSV) are two different clinical conditions. The vaginal microbiota was evaluated in 200 women (50 healthy pregnant (HPW) during the first trimester, 100 patients with BV 50 NSV). samples received from both (121 samples) (BV 241 samples, NSV 136 contained lactobacilli (96.5%), peptostreptococci (52.2%), streptococci (36.4%), bifidobacteria (48.2%), propionibacteria (34.3%). Other microorganisms...
According to Russian classification, bacterial vaginosis (BV) and nonspecific vaginitis (NSV) are two different clinical conditions. The vaginal microbiota was evaluated in 200 women (50 healthy pregnant (HPW) during the first trimester, 100 patients with BV 50 NSV). samples received from both (121 samples) (BV 241 samples, NSV 136 contained lactobacilli (96.5%), peptostreptococci (52.2%), streptococci (36.4%), bifidobacteria (48.2%), propionibacteria (34.3%). Other microorganisms...
According to the World Health Organization, every year about 1 million cases of purulent bacterial meningitis (PBM) are registered in world, which 200 thousand end death. Bacterial is polyethiologic, makes task determining pathogen main organization epidemiological surveillance, treatment regimens, planning preventive and anti-epidemic measures. The quality laboratory diagnostics has a key influence on this. true incidence different etiology can be altered at low-efficiency diagnostics. This...
The aim of the present systematic literature review is to summarize data on role TLRs in maintaining homeostasis female genitals, physiological development pregnancy, provision anti-infective resistance pregnant women with intrauterine infection. substantiates importance genitals as a necessary and determining factor reaction various changes environment, also responsible for metabolic, structural, or energy, maintenance homeostasis. As universal regulators vital activity organism conjunction...
Alteration of microbiota composition is a trigger, and, sometimes, an etiological factor in the development chronic skin diseases, e.g., psoriasis or eczema. Recognition microflora by keratinocytes and immune cells leads to production antimicrobial peptides, chemokines growth factors, which contribute differentiation T lymphocytes autoaggressive effector Th1, Th17 Th22 types that implement autoimmune inflammation psoriatic plaque. The aim our work was study differences spectrum parameters...
The effect of dental gel with astaxanthin and polyprenol on the detection toxicity local irritant laboratory animals was evaluated. inflammatory reaction, wound healing effect, hematological biochemical parameters were studied when using a polyprenol. When conducting study animals, showed absence effect. antioxidant properties, as well effects animals.
Introduction. Chronic and latent infections are often activated during pregnancy.Aim - to asses the pathogenetic role of microbial pathogens in urogenital tract infection (UTI) pregnant women.Materials methods. 89 women underwent general clinical examination, examination smears from urethra, vagina, cervical canal; bacteriological analysis vaginal contents; enzyme-linked immunosorbent assay, polymerase chain reaction determination specific antibodies for verification herpes simplex virus...
Background. The current epidemiology of pneumococcal meningitis in Ukraine, Georgia and countries CIS is poorly studied. In order to ensure an effective vaccination strategy post-vaccination surveillance, we examined the serotype distribution patterns following regions: European (Ukraine, Belarus), Transcaucasian (Azerbaijan, Armenia, Georgia), Asian (Uzbekistan, Kyrgyzstan, Kazakhstan). study was performed within program for Invasive Bacterial Diseases Sentinel Surveillance implemented...