A5075034170- Cancer-related molecular mechanisms research
- Amyloidosis: Diagnosis, Treatment, Outcomes
- RNA modifications and cancer
- Atherosclerosis and Cardiovascular Diseases
- Renal Diseases and Glomerulopathies
- Renal function and acid-base balance
- MicroRNA in disease regulation
- Lipid metabolism and disorders
- Biomedical Research and Pathophysiology
- High Altitude and Hypoxia
- Metabolism and Genetic Disorders
Harvard University
2022-2024
Brigham and Women's Hospital
2024
Diabetes-associated atherosclerosis involves excessive immune cell recruitment and plaque formation. However, the mechanisms remain poorly understood. Transcriptomic analysis of aortic intima in Ldlr−/− mice on a high-fat, high-sucrose-containing (HFSC) diet identifies macrophage-enriched nuclear long noncoding RNA (lncRNA), MERRICAL (macrophage-enriched lncRNA regulates inflammation, chemotaxis, atherosclerosis). expression increases by 249% intimal lesions during progression. lncRNA-mRNA...
Introduction: Diabetes-associated atherosclerosis is characterized by excessive vascular wall inflammation, including impaired lipid deposition, increased immune cell infiltration and plaque formation in the vessel wall. Macrophages are instrumental for lesion formation, however mechanisms underlying their functional capacity remain poorly understood diabetes. Herein, we identify a unique role of macrophage-enriched lncRNA MERRICAL (Macrophage Enriched Regulates Inflammation, Chemotaxis,...