Destructive nonlinear processes have limited the useful input power to a few megawatts for supercontinuum generation in bulk material. Consequently, reliable high-power, high-pulse-energy condensed media has not been realized. Here, we describe an intense femtosecond generated solid medium with pulse energy and mode quality that approach those gas phase while preserving advantages of being compact, simple operate, highly reproducible. This is achieved by strategically placing several thin...

A simple and efficient optical interference method for fabricating high quality two- three-dimensional (2D 3D) periodic structures is demonstrated. Employing multi-exposure of two-beam technique, different types are created depending on the number exposure rotation angle sample each exposure. Square hexagonal 2D fabricated by a pattern with 90 masculine 60 between two exposures, respectively. Three-exposure, in particular, results kinds 3D structures, close lattice constants transverse...

Selective detection of biomarkers at low concentrations in blood is crucial for the clinical diagnosis many diseases but remains challenging. In this work, we aimed to develop an ultrasensitive immunoassay that can detect serum with attomolar limit (LOD). We proposed a sandwich-type heterogeneous immunosensor 3 × well array format by integrating resonant waveguide grating (RWG) substrate upconversion nanoparticles (UCNPs). UCNPs were used label target biomarker captured capture antibody...

Abstract Glassy isotactic propylene (PP) films of thickness up to 0.3 mm were obtained by an ultraquenching technique. The structure and properties the as‐quenched subsequently crystallized samples characterized various techniques. Electron microscopy indicates glass has no larger than 25 Å. X‐ray diffraction shows PP crystallizes from into a smectic at ca. −20°C then transforms monoclinic microcrystals 40°C; nodular (80 100 Å in diameter) was observed on surface. transformation temperature...

By embedding NaYF4:Yb3+,Tm3+ nanocrystals into the top cladding layer of a resonant waveguide grating structure, we demonstrate that upconversion fluorescence Tm3+ ions can be greatly enhanced, by factor up to 104. The structure consists an SU8 bottom with sinusoidal morphology coated thin TiO2 and then covered poly(methyl methacrylate) doped nanocrystals. giant enhancement is achieved first coupling excitation light guided mode fluorescent second mode. Our numerical simulation results...

MicroRNAs (miRs) downregulate or upregulate the mRNA level by binding to 3'-untranslated region (3'UTR) of target gene. Dysregulated miR levels can be used as biomarkers Parkinson's disease (PD) and could participate in etiology PD. In present study, 45 brain-enriched miRs were evaluated serum samples from 50 normal subjects sporadic PD patients. The miR-204-5p was upregulated An also observed substantia nigra (SN) 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) mouse model Expression...

In this work, we present efficient, robust, and transparent electromagnetic interference (EMI) shielding by a hybrid material comprised of nickel (Ni) mesh conformal graphene coating. We demonstrate that 20 nm-thick graphene/Ni can provide EMI effectiveness (SE) exceeding 12.1 dB (∼93.6% power attenuation) in the decimeter band while retaining high visible transmittance ∼83%. Its maximum achieved SE value was 26.6 (∼99.5% at 0.75 GHz. Furthermore, thicker Ni exhibited higher SE. Compared to...

Ultraquenching of thin films (∼1000 Å) was used to obtain glassy poly(vinylidene fluoride) (PVF2). Electron microscopy indicates the glass has no structure larger than 20 Å. diffraction crystallization forms from at ∼−30 °C into β form. Rapid results in development a nodular, microcrystalline morphology which can be changed only by annealing above Tα. Thick (∼80 μm) could not ultraquenched glass; ultraquenching α form crystals bulk and on surface. These thicker were characterized x-ray...

Changes in DNA methylation are associated with changes somatic cell fate without the alteration of coding sequences. In addition to its use as a traceable biomarker, reversible could also serve therapeutic target. particular, if development drug resistance is methylation, then demethylation might reverse phenotype. The reversion drug-resistance be feasible association between abnormal and identified. Methylation differences cervical cancer cell, SiHa, derived oxaliplatin-resistant S3 cells...

The biocharacteristics of xenogeneic grafts make them a possible substitute for autogenous bone in dental graft procedures. This study aimed to develop novel porcine with collagen capable generating new defects via osteoconduction over 8 weeks healing and compare it graft. was made undergo cell viability test (MTT) alkaline phosphatase assay (ALP). surgical procedure performed 20 male adult New Zealand white rabbits. Four calvarial critical-size 6 mm diameter were prepared each rabbit. upper...

Abstract Patients with familial type 17 of Parkinson’s disease (PARK17) manifest autosomal dominant pattern and late-onset parkinsonian syndromes. Heterozygous (D620N) mutation vacuolar protein sorting 35 (VPS35) is genetic cause PARK17. We prepared heterozygous VPS35 D620N/+ knockin mouse, which an ideal animal model VPS35-induced Late-onset loss substantia nigra pars compacta (SNpc) dopaminergic (DAergic) neurons motor deficits were found in 16-month-old mice. Normal function...

Ruthenium σ-acetylides containing a dangling pyridine were synthesized from the reactions of CpRu(L)2Cl (L = PPh3, 1/2 (C5H4PPh2)2Fe) with 4-ethynylpyridine, (E)-1-(4-ethynylphenyl)-2-(4-pyridyl)ethylene, or 4-(ethynylphenyl)(4-pyridyl)acetylene in presence NH4+PF6- followed by deprotonation base. The can be protonated, methylated, ligated to tungsten carbonyl fragments. ruthenium donor pyridinium acceptor charge-transfer absorption appears at longer wavelength as conjugation chain becomes...

This work demonstrates the fabrication of a simple, low-cost microlens array (MLA) diffuser film with controllable haze distribution (diffusion effect) by combination "breath figures" (BFs) and micro-replica molding methods. Polystyrene (PS) molds obtained BFs method contain concave, hexagonal packed air holes formed condensation water vapor on cooling surfaces in chamber which relevant influence factors can be controlled. The sizes PS controlled varying such as temperature, relative...

We report a versatile strategy to exploit parafilm waste as carbon precursor for fabrication of freestanding, hollow few-layer graphene fiber mesh (HFGM) structures without use any gaseous carriers/promoters via an annealing route. The freestanding HFGMs possess good mechanical flexibility, tailorable transparency, and high electrical conductivity, consequently qualifying them promising electrochemical electrodes. Because the spaces, electrolyte ions can easily access into contact with...

We demonstrate a promising method to fabricate large-area periodic structures with desired defects by using the combination of multiple-exposure two-beam interference and mask-photolithography techniques. Multiple-exposure pattern at 325 nm into positive AZ-4620 (or negative SU-8) photopolymerizable photoresist is used form square hexagonal two-dimensional structures. Desired are introduced in these irradiating sample one beam same laser through mask which design patterned. A 1cm x lattice...

We present a novel type of surface-enhanced Raman scattering (SERS) substrate constituted 3-dimensinal polymeric inverse opal (IO) photonic crystal frame with gold nanorods (Au-NRs) decorating on the top layer. This employs resonant excitation as well constructive backward signals to produce large enhancement SERS output. For incoming excitation, Au-NRs appropriate aspect ratio were adopted align their longitudinal localized surface plasmon band laser wavelength. outgoing signal, spectral...

Lateral heterojunctions in two-dimensional (2D) materials have demonstrated potential for high-performance sensors because of the unique electrostatic conditions at interface. The increased complexity producing such structures, however, has prevented their widespread use. We here demonstrate simple and scalable fabrication by a one-step synthesis process that yields photodetectors with superior device performance. Catalytic conversion solid precursor optimized was found to produce lateral...

The enhancement of upconversion luminescence (UCL) rare earth doped nanoparticles (UCNPs) in aqueous solution is particularly important and urgently required for a broad range biomedical applications. Herein, an effective approach to achieve highly enhanced UCL from NaYF4:Yb3+,Tm3+ UCNPs presented. We demonstrate that these can be more than 104-fold by using mesoporous silica low refractive index resonant waveguide grating (low-n RWG) contact with solution, which makes it well-suited...

Ruthenium σ-acetylides with an end-capping organic electron acceptor and thienyl entity in the conjugation chain, Ru(C⋮CY)(PPh3)2(η5-C5H5) (Y = th-CHO, th-CHC(CN)2, th-(E)-CHCH-th-CHO, th-(E)-CHCH-th-CHC(CN)2, C6H4-(E)-CHCH-th-NO2, th-(E)-CHCHC6H4-4-NO2, C6H4C⋮C-th-NO2, th-(E)-CHCH-th-CHCHC6H4-4-NO2, C6H4NC(H)-th-NO2, th-(E)-CHCHC5H4N+Me, th-C⋮CC5H4N+Me, th-(E)-CHCH-th-NO2, th-C⋮C-th-NO2) (th 2,5-disubstituted thiophene), were synthesized. These complexes exhibit intense charge transfer from...

We demonstrate theoretically and experimentally a useful technique for fabrication of two- three-dimensional (2D or 3D) quasi-periodic structures by double-exposure periodic interference pattern. With three-beam three-beam-plus-one techniques, one can fabricate 2D 3D structure having six-fold symmetry, respectively. When this is duplicated in another orientation, its combination results twelve-fold symmetry structure. Experimental obtained using two-exposure and/or pattern at 442 nm into...

Corrosion protection of complex surface is an active area research due to its importance commercial applications such as electrochemical fabrication. However, conventional coatings exhibit limited conductivity, thermal stability, and durability are thus not suitable. Recent work has shown the potential graphene, a two-dimensional carbon allotrope, for corrosion protection. The studies, however, themselves simple planar geometries that provide insight in applicability relevant morphologies...